Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cyclosporine is being used with increasing frequency in the prevention and treatment of graft-versus-host disease (GVHD) in patients undergoing allogeneic bone marrow transplant (BMT). Based on the manufacturer's administration recommendations, many institutions administer cyclosporine through one lumen of a silastic catheter with the other lumen designated for hyperalimentation, antibiotics, and blood products. Administration of many antibiotics incompatible with hyperalimentation or transfusion of multiple blood products may jeopardize the patient's nutritional support. A survey was undertaken to collect information on administration practices. It was found that the majority of BMT centers used cyclosporine in their GVHD protocols and had a variety of practices for its administration. To more adequately meet the nutritional needs of this patient population, national standards for administering cyclosporine should be developed. In addition, further research is needed to determine the compatibility of cyclosporine with a variety of intravenous solutions and drugs.
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PMID:Cyclosporine administration practices on bone marrow transplant units: a national survey. 211 35

Sixty outbred Wistar rats were randomly assigned to five experimental groups: GI-10 non-diabetic control rats; GII-10 untreated diabetic control rats; GIII-10 diabetic rats treated with retard porcine insulin; GIV-20 diabetic rats that received pancreaticoduodenal transplantation (PDT) from normal donor rats; GV-10 diabetic rats submitted to islet of Langerhans transplantation (ILT) into the portal vein. The animals were housed in metabolic cages for six periods of 24 hours during 30 days and body weight, water and food intake, urine output, blood and urinary glucose were recorded. Diabetes was induced by I.V. administration of Alloxan (42 mg/kg of body weight); PDT was performed by microsurgical techniques and islets were prepared without enzymes. To prevent rejection. Cyclosporin A (10 mg/kg of body weight) was utilized in transplanted rats. PDT consistently and significantly (p < 0.05) improved the metabolic abnormalities of the diabetic rats, by restoring the body weight gain, and immediate relief of polydipsia, polyphagia, polyuria, hyperglycemia and glucosuria observed in pre-treatment period. PDT was more effective than ILT and this over insulin therapy on control of the diabetic state. However, the observed complications in GIV and GV, due to surgery and immunosuppression, should be analysed for the real benefits of the alternative therapy can be superior to eventual fails to the conventional therapy with insulin.
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PMID:[A comparative study of pancreatic-duodenal transplantation, islets of Langerhans transplantation, and insulin treatment, in the control of experimental diabetes in the rat]. 824 60

We report a case of steroid-refractory ulcerative colitis, treated with cyclosporine, in a 38-year-old woman with a 13-year history of ulcerative colitis. No remission was achieved with treatments that included intravenous hyperalimentation, sulfasalazine, and intensive parenteral prednisolone therapy for 4 weeks. Intravenous infusion of cyclosporine was performed because the patient refused to undergo surgery. Her condition improved dramatically and colectomy was avoided. She has been maintained on oral cyclosporine and azathioprine since steroids were discontinued, and she has remained in clinical and endoscopic remission for 2 years. The side effects were not significant, but mild paresthesia in both hands and mild hypertension, which was controlled by anti-hypertensives. Cyclosporine seems to be an effective treatment for patients with steroid-refractory severe active ulcerative colitis in whom colectomy seems inevitable. We believe further clinical trials of the treatment are warranted.
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PMID:Steroid-refractory severe ulcerative colitis responding to cyclosporine and long-term follow-up. 971 55

Feline herpesvirus 1 (FHV-1) is a common ocular and respiratory pathogen of cats that can be associated with recurrent clinical signs of disease. Ciclosporin (cyclosporine) is commonly administered per os (PO) for the treatment of a number of inflammatory diseases in cats. A number of client-owned cats administered ciclosporin (cyclosporine) A (CsA) PO to block renal transplant rejection have developed clinical signs of upper respiratory tract disease that may have been from activated FHV-1. In this study, cats experimentally inoculated with FHV-1 several months previously were administered methylprednisolone acetate intramuscularly, CsA PO or a placebo PO. While clinical signs of activated FHV-1 occurred in some cats, disease was mild and self-limited in most cats. There was no vomiting, diarrhea, inappetence, weight loss, polydipsia, polyuria or polyphagia recognized.
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PMID:Effect of ciclosporin and methylprednisolone acetate on cats previously infected with feline herpesvirus 1. 2520 53