Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Amino acid mixture prescribed for an hyperalimentation solution (PN-twin) diminishes suppression of anti-Candida activity of neutrophils as reported previously (Tansho, T, et al. J. Jpn. Assoc. Infect. Dis. 70: 463-469). The aim of this study was to identify the active principle in the amino acid mixture and to examine its action mechanism. Amino acid mixture (PN-twin) containing 23 amino acids neutralized the suppression of anti-Candida activity of human neutrophils by 1.0% of glucose. These amino acids were divided to several groups by their structure and effects of the groups on the suppressed anti-Candida activity neutrophils were examined. In all groups tested, amino acids containing cystein and methionine clearly neutralized the suppression, especially cysteine at the concentration more than 20 micrograms/ml significantly recovered the anti-Candida activity of neutrophils which was suppressed in the presence of 1% glucose or 10(-6) M dexamethasone. Correspondingly, cysteine augmented production of lactoferrin by stimulated neutrophils; which functions as a major effector molecule in growth inhibition of Candida by neutrophils. These results suggest that cysteine in alimentation solution augments anti-Candida defense mechanisms through recovery of neutrophil function.
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PMID:[Reverting effect of cysteine on the suppression by glucose or dexamethasone of anti-Candida activity of human neutrophils]. 974 23

Dairy proteins-whey protein, in particular-are satiating and often recommended for weight control; however, little is known about the mechanisms by which whey protein and its components promote satiety and weight loss. We used diet-induced obese rats to determine whether the hypophagic effects of diets that are enriched with whey and its fractions, lactalbumin and lactoferrin, are mediated by the gut hormone, peptide YY (PYY). We demonstrate that high protein diets that contain whey, lactalbumin, and lactoferrin decreased food intake and body weight with a concurrent increase in PYY mRNA abundance in the colon and/or plasma PYY concentrations. Of importance, blockade of PYY neuropeptide Y receptor subtype 2 (Y2) receptors with a peripherally restricted antagonist attenuated the hypophagic effects of diets that are enriched with whey protein fractions. Diets that are enriched with whey fractions were less preferred; however, in a modified conditioned taste preference test, PYY Y2 receptor blockade induced hyperphagia of a lactoferrin diet, but caused a reduction in preference for Y2 antagonist-paired flavor, which suggested that PYY signaling is important for lactoferrin-induced satiety, but not essential for preference for lactoferrin-enriched diets. Taken together, these data provide evidence that the satiety of diets that are enriched with whey protein components is mediated, in part, via enhanced PYY secretion and action in obese male rats.-Zapata, R. C., Singh, A., Chelikani, P. K. Peptide YY mediates the satiety effects of diets enriched with whey protein fractions in male rats.
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PMID:Peptide YY mediates the satiety effects of diets enriched with whey protein fractions in male rats. 2904 49