Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A randomized study of the effects of methionine-deprived amino acid solution (AO-90) on the metabolism of 5-FU was performed in patients with advanced gastric or colorectal cancers. Continuous intravenous hyperalimentation with either AO-90 or conventional amino acid solution (control group) in combination with 5-FU was performed for 7 days preoperatively under the fasting condition. The administration of AO-90 showed a decreased level of serum methionine and resulted in the subsequent increased tendency in the intratumorous levels of both folic acid and methylene tetrahydrofolate compared to those of the control group. In the AO-90 group, the inhibition rate of thymidilate synthase in the tumor was significantly higher than that of the control group. These results indicate that AO-90 plays an important role in the metabolism of 5-FU and seems to contribute to the increased antitumor effect of 5-FU as a biochemical modulator.
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PMID:[Methionine-deprived amino acid solution-induced biochemical modulation of 5-FU and augmentation of the antitumor activity]. 158 Jun 36

A study was conducted on weekly infusion of high-dose 5-FU by way of the hepatic artery for liver metastases from colorectal cancer. In the evaluation of 13 cases, no CR and 6 PR were observed. The response rate was 46.2%, 1-year survival was 73% and 1.5-year survival was 42%. No patients suffered from major side effects. Two patients had ileus, which was controllable by supportive care with intravenous hyperalimentation, and was caused by peritoneal dissemination of cancer. In conclusion, this regimen was relatively safe, effective, and useful for improving the quality of life of patients, compared with other regimens. How to control extrahepatic metastases in addition to this regimen is a subject for forthcoming study.
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PMID:[Weekly hepatic arterial infusion of high-dose 5-FU for liver metastases from colorectal cancer]. 825 47

Home anti-cancer chemotherapy was performed for patients with advanced cancer of the digestive plantable venous port placed beneath the skin via the subclavian vein. 128 patients under 75 years old (enrolled: 6 patients with esophageal, 65 with gastric, 44 with colorectal, 5 with cholangio, 5 with pancreatic, one with hepatic and one with ileal cancer) were treated. Continuous intravenous infusion of 5-FU (300-400 mg/body/day) combined with low-dose injection of cisplatin (5 mg/body/day) was continued for 10 days, and repeated 3 times for 6 weeks. The response rate was 23.6% in 72 patients with valuation of tumor mass. In 83 patients for whom a tumor marker evaluation was also performed, an effect was seen in 30.1%. No severe side effects such as renal dysfunction were observed, and no special infusions were needed. Therefore, a quality of life was maintained in which bathing was possible and patients were released from the hospital. Hyperalimentation through the venous port, and palliation during the terminal stage, is easily accomplished. It is useful method for surgery, chemotherapy and palliative therapy in the treatment of cancer.
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PMID:[Home anti-cancer chemotherapy with continuous infusion of 5-FU combined with low-dose cisplatin injection via implantable venous port with portable balloon pump]. 1063 Feb 41