Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Intraaccumbens infusions of the GABA(B) agonist baclofen are known to stimulate food intake in the rat. The aim of the present study was to evaluate the effects of baclofen infusion on nonfood-related chewing and on the consumption of a palatable fluid. Rats were bilaterally infused with baclofen (188 ng in 1 microL) or saline, and tested in a situation in which food was available in one or two locations and wood blocks might also be present. Baclofen-infused animals showed no enhancement of chewing directed at the wood blocks, but showed increased food consumption regardless of food location. In a second, separate test we recorded the microstructural parameters for drinking of a palatable glucose/saccharin mixture. Baclofen infusion had no effect on overall intake, although bout size was reduced and the number of bouts was increased. These data confirm that baclofen-stimulated food intake following accumbens infusion is a robust and substantial phenomenon that appears to be selective to solid food. It is likely to result from relatively direct activation of neural circuits for feeding, rather than an indirect facilitation consequent upon changes in taste processings, as has been suggested for some other examples of drug-induced hyperphagia.
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PMID:Intraaccumbens baclofen selectively enhances feeding behavior in the rat. 1071 85

Excess consumption of palatable food has been shown to affect reward-related brain regions, and pharmaceutical treatments for drug addiction may also be effective in treating overeating of such foods. The GABA-B agonist baclofen and opioid antagonist naltrexone have both been used to treat addiction, and have been shown to suppress intake of certain foods. The combination of these drugs has shown to be more effective in reducing alcohol consumption than either drug alone. The present study assessed the effects of naltrexone and baclofen, alone and in combination, on intake of foods comprised of various macronutrients. Male Sprague-Dawley rats were given 12-hr daily access to chow and a fat emulsion, sugar-fat emulsion, or a sugar solution for 21 days. Rats were then administered (intraperitoneal) baclofen-naltrexone combinations (0.1 mg/kg naltrexone and 1.0 mg/kg baclofen, 1.0 mg/kg naltrexone and 1.8 mg/kg baclofen), and naltrexone (0.1, 1.0 mg/kg) and baclofen (1.0, 1.8 mg/kg) alone. The high dose of the baclofen-naltrexone combination reduced palatable food intake in both the fat and sugar-fat groups compared with vehicle, without affecting chow consumption in these groups. Naltrexone showed little significant effects on intake of either palatable food or chow. Baclofen also reduced palatable food intake in the fat and fat-sugar groups, but differences were only noted between the low and high dose. The combination of baclofen and naltrexone may be a useful tool in selectively targeting the consumption of high-fat and sugar- and fat-rich foods.
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PMID:Effects of baclofen and naltrexone, alone and in combination, on the consumption of palatable food in male rats. 2506 13