Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020505 (
hyperphagia
)
6,116
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
This study investigated the genetic and environmental contributions to emotional
overeating
(EOE) and depressive symptoms, and their covariation, in a Sri-Lankan population, using genetic model-fitting analysis. In total, 3957 twins and singletons in the
Colombo
Twin and Singleton Study-Phase 2 rated their EOE behaviour and depressive symptoms, which were significantly associated (men:
r
= 0.11, 95% confidence interval (CI) 0.06-0.16, women:
r
= 0.12, 95% CI 0.07-0.16). Non-shared environmental factors explained the majority of variance in men (EOE
e
2
= 87%, 95% CI 78-95%; depressive symptoms
e
2
= 72%, 95% CI 61-83%) and women (EOE
e
2
= 76%, 95% CI 68-83%; depressive symptoms
e
2
= 64%, 95% CI 55-74%). Genetic factors were more important for EOE in women (
h
2
= 21%, 95% CI 4-32%) than men (
h
2
= 9%, 95% CI 0-20%). Shared-environmental factors were more important for depressive symptoms in men (
c
2
= 25%, 95% CI 10-36%) than women (
c
2
= 9%, 95% CI 0-35%). Non-shared environmental factors explained the overlap between depressive symptoms and EOE in women but not in men. Results differed from high-income populations, highlighting the need for behavioural genetic research in global populations.
...
PMID:The association between emotional eating and depressive symptoms: a population-based twin study in Sri Lanka. 3110 66
