Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Candida albicans arthritis is uncommon. Although occasional instances of meningitis, osteomyelitis, endocarditis, pneumonia, and extensive visceral involvement due to Candida species have been reported, only 7 documented cases of arthritis caused by Candida albicans are found in the literature. The present case was an infant with a gastroschisis defect of the abdominal wall, who required multiple surgical procedures, prolonged antibiotic therapy, and parental intravenous hyperalimentation. Following a blood stream infection with Candida albicans, septic arthritis of the left knee developed. Treatment with intravenous Amphotericin-B over a 6-week period was successful in eridicating the infection. The child is completely well 9 months after discharge from the hospital. Factors which may predispose patients to infection by Candida albicans include prolonged antibiotic therapy. corticosteroids, generalized debilitation, malnutrition, parental hyperalimentation, and immunosuppressive therapy. Amphotericin-B therapy may be associated with considerable toxicity including azotemia, hepatic dysfunction, and hematologic abnormalities. The therapeutic regimen of Amphotericin-B is effective but a 6-week course of antifungal therapy may be necessary to eradicate septic arthritis of Candida albicans. Surgical drainage is probably indicated only for recent infections.
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PMID:Candida arthritis. A case report and review of the literature. 80 14

Hansenula anomala is a yeast which has seldom been reported as a human pathogen. A case of fungaemia with this organism is described in a 22-year-old patient with chronic myeloid leukaemia undergoing a second HLA-matched sibling transplant. A Hickman catheter was in situ and hyperalimentation commenced on day -1. Fever developed on day +10 and H. anomala was isolated from blood cultures. The patient was receiving cyclosporin and methotrexate as prophylaxis against graft-versus-host disease and was severely neutropenic. Treatment with amphotericin B was commenced and the patient's Hickman catheter was removed. Fever resolved and subsequent blood cultures were negative. Amphotericin was continued to a cumulative dose of 680 mg and oral fluconazole 400 mg/day was given for a further week. H. anomala infection has been reported in premature babies and in immunosuppressed individuals but has not been previously observed in patients undergoing bone marrow transplantation. Clinical features of previously reported cases of infection with H. anomala are reviewed.
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PMID:Hansenula anomala infection after bone marrow transplantation. 771 79