Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This research reports the development and initial investigation of the reliability and validity of the Dieter's Inventory of Eating Temptations (DIET), a self-report inventory designed to assess behavioral competence in six types of situations related to weight control: (a) overeating, (b) negative emotions, (c) exercise, (d) resisting temptation, (e) positive social, and (f) food choice. The scales were shown to have adequate test-retest reliability and internal consistency. A comparison of 193 normal weight and 168 overweight subjects showed that overweights rated themselves as less competent in the overeating, negative emotions, and exercise situations. As a further validation, DIET scores were compared with measures of eating style derived from self-monitoring records. All of the DIET scales were significantly associated with specific parameters of eating behavior. In order to identify subtypes of overweight and normal weight individuals, cluster analyses were performed. Normal weight and overweight subjects could be grouped into interpretable clusters based on their profile of DIET scores. These data suggest that there is a relationship between eating patterns and body weight, and that there may be several types of problem behavior patterns. Treatment programs should combined assessment of behavioral competency in energy balance situations with intensive skill training in areas where situation specific competency deficits are found.
 ...
PMID:The Dieter's Inventory of Eating Temptations: a measure of weight control competence. 336 23

Over 15 years ago, a psychobiosocial theory of appetite was formulated in the light of experimental evidence from rats and people that appetite was suppressed by the flow of energy to lean body mass and that much ingestion was a learned response to integrated dietary, somatic and social cues. Enough was known in 1973 about these influences on food intake and about rates of flow of energy-yielding substrates around the body of the rat to program a computer simulation which had no loose parameters. This rat model successfully predicted feeding patterns under a variety of normal and abnormal conditions, including the day-night meal rhythm, the overeating and obesity following ventromedial hypothalamic lesions, and the suppression of appetite by fenfluramine via slowed gastric emptying. In 1976, its parameter values were adjusted to those expected for an adult person having food freely available and a sedentary lifestyle. The output of this human model was remarkably realistic in meal pattern: culture appears to adapt to the physiological average. The predicted effect on appetite of energy released from adipose in proportion to the energy stored was relatively minute but very persistent. These old results are no less relevant now to improvement of our understanding of human food-intake controls and to more effective reduction and prevention of unhealthy overweight.
 ...
PMID:A simulation model of psychobiosocial theory of human food-intake controls. 338 75

Rats with obesity-producing, hypothalamic knife cuts (KC) were fed a purified high fat diet for 9 wk. KC rats consumed more energy (+70-100%) and retained energy with a much higher efficiency than control rats. Adrenalectomy of KC rats 1 wk (before gross obesity was evident) or 5 wk (when KC rats were 70% overweight) after KC surgery caused a reduction in energy intake to levels approximating those of control rats. Furthermore, energy retention in adrenalectomized KC rats was depressed more than could be explained on the basis of the reduction in energy intake. Two factors associated with the reduction in energy retention, urinary excretion of norepinephrine, an indicator of sympathetic nervous system activity, and GDP binding to brown adipose tissue mitochondria, an indicator of the thermogenic capacity of the tissue, were higher in vadrenalectomized KC rats than in pair-fed KC rats. Removal of the adrenals not only suppressed hyperphagia in KC rats fed a high fat diet, but also increased energy expenditure per kilocalorie consumed.
 ...
PMID:Energy balance in rats with obesity-producing hypothalamic knife cuts: effects of adrenalectomy. 359 23

A young adolescent girl (13.5 years old) with a compulsive eating disorder and gross obesity was treated with a combination of behavior therapy and fenfluramine (Ponderax). The behavior modification program used was adapted from Reiss's program, an approach that had proven effective in individuals with hyperphagia and overweight who had no additional emotional problems or brain damage. In our patient the problem was complicated by the presence of autism, with compulsive eating being particularly ingrained as a form of stereotyped behavior. We therefore decided to administer fenfluramine concurrently because it is known to have both an appetite-depressing effect and a positive effect on behavioral disturbances characteristic of autistic individuals. During inpatient treatment the girl lost weight and showed changes in behavior. The changed eating behavior was still being maintained many months after discharge and after fenfluramine had been discontinued. We assume that drug treatment provided an important kind of support for the behavioral treatment program. Further, we attribute the emotional stabilization in this autistic girl to fenfluramine. We now plan to extend this treatment approach to other subjects with similar problems.
 ...
PMID:[Treatment of compulsive eating disorders in an autistic girl by combining behavior therapy and pharmacotherapy. Case report]. 376 95

Chronic administration of benzodiazepines is known to increase food intake in numerous species. But this effect has been studied only after a unique daily injection and over a short part of the 24 hr cycle. In the present study, during 28 days, drugs were administered to rats receiving ordinary chow or a highly palatable diet (cafeteria diet): diazepam (DZ) (2.5 mg/kg IP) twice a day, or brotizolam (BR) (1 mg/kg IP), a longer acting compound, once a day. In the chow fed rats, DZ and BR provoked a post injection hyperphagia throughout the study, followed by a compensatory hypophagia resulting in 24 hr food intakes not different from those of controls; conversely neither body weight nor weight of fat pads were increased. The cafeteria diet provoked hyperphagia and overweight. DZ did not induce any supplementary hyperphagia. BR provoked a post injection hyperphagia, also compensated in time, resulting again in 24 hr food intakes, body weight gains and weight of fat pads not increased compared to those of cafeteria controls. Thus in the rat, benzodiazepine treatment increases food intake, but only acutely, and does not provoke any trend toward obesity.
 ...
PMID:Effects of a chronic administration of two benzodiazepines on food intake in rats given a highly palatable diet. 378 48

Twenty-eight adolescents with eating disorders were analyzed in a study that included a retrospective examination of their hospital records and a letter to their family doctor and the patient. These 28 patients were dieting to lose weight, with nine reporting episodes of overeating and vomiting. The clinical characteristics of the bulimic patients versus the nonbulimic are contrasted. Bulimic patients tended to be older and ill for longer. They had a higher weight score, vomited more, and used laxatives and diet medications more frequently. They threatened suicide more often than nonbulimics and many had been overweight previously. Poor outcome was positively associated with bulimia, longer duration of illness, and older age of presentation, but not with a lower weight during the illness. However, with the exception of the presence of vomiting and being less likely to feel fat, these differences in clinical characteristics between bulimic and nonbulimic groups did not approach the level of statistical significance.
 ...
PMID:Adolescents with bulimic and nonbulimic eating disorders. 385 98

Fourteen patients originally presented with hyperphagia and intractable morbid obesity have had maxillomandibular fixation (MMF) applied in an effort to control their obesity. In 10 patients who were massively obese or considered poor risk candidates for surgical control of their obesity, MMF was applied with the aim of reducing the obesity to a level where a surgical gastric restrictive bariatric procedure could be safely carried out. Eight of these patients had been rejected for surgical control of obesity elsewhere and two were edentulous. Five of these patients after successful weight loss over periods from 16 to 40 weeks (mean percentage overweight lost 84.8, range 39-150) safely underwent a gastric restrictive procedure. All five patients have had continuous weight loss after bariatric surgery. Two patients requested removal of MMF 1 and 2 weeks after application. The remaining three patients, who were candidates for surgery, after successful weight loss over periods from 12 to 28 weeks (mean percentage of overweight lost 45, range 38-50) decided not to proceed with surgical control. All have subsequently regained the lost weight. Four originally morbidly obese patients, who had had a previously successful gastric restrictive procedure followed by weight loss, requested MMF in an effort to lose further weight. Over periods from 8 to 16 weeks three of the four had further weight loss (mean percentage of overweight lost 18.3, range 5-30). After removal of MMF all four patients regained some weight. In only one was there a significant maintenance of weight lost during MMF.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Jaw wiring in the treatment of morbid obesity. 386 88

Laboratory studies using direct calorimetry, a technique which is no longer either rare or difficult, have shown no essential differences between men and women who gain weight easily and the always lean. Both groups gained weight similarly when overeating by 1,000 kcal X d-1. Thermogenic responses to eating and the energy losses in food and urine were similar in the overweight and lean. Daily sedentary energy expenditure is a function of fat-free mass, and fat-free mass increases with obesity. During exercise, calorimetry has shown that heat losses are not always exactly matched to heat production as calculated from respiratory gas exchange, but a 24-h exercise period with a cycle ergometer showed reasonable energy balance when subjects ate as much as they spent. During weight loss from restricting food intake by 1,000 kcal X d-1, calorimetry showed a 12% reduction in sedentary energy expenditure. Based on calorimetry studies and other evidence in the literature, exercise increases energy expenditure, it may eliminate the reduced energy expenditure of caloric restriction, and it can increase muscle mass and thus increase both fat-free mass and daily expenditure.
 ...
PMID:Direct calorimetry and the energetics of exercise and weight loss. 395 60

In this study of overeating and undereating, the terms in energy exchange were measured by 24-h direct and indirect calorimetry, bomb calorimetry of food and feces, and changes in body weight and composition; on average, the terms balanced to within 200 to 300 kcal/day. All subjects, whether habitually lean or overweight, gained weight similarly during overeating and lost similarly during undereating. Nor was there any difference in the adaptive thermogenesis of overweight and lean men and women.
 ...
PMID:The exchange of matter and energy in lean and overweight men and women: a calorimetric study of overeating, balanced intake and undereating. 406 34

In a survey of 190 chronic mentally disabled patients we found a significantly higher prevalence of overweight and obesity in both sexes, especially women, compared with the general population. The apparent causes were overeating, underactivity, ignorance of correct dietary principles and the differential effects of various psychotropic drugs which we were able to measure. Some preventive ideas are suggested.
 ...
PMID:Too many chronic mentally disabled patients are too fat. 407 23


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>