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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Stem bark extracts of Terminalia superba Engl. and Diels and Canarium schweinfurthii Engl. are used in Africa for the treatment of various ailments, including diabetes mellitus. The anti-diabetic effects of the methanol/methylene chloride extracts of the stem barks on streptozotocin (STZ)-induced diabetes were evaluated on male rats. Through the subcutaneous route, diabetes was induced using 60 mg/mL of streptozotocin. After 2 days, the rats received, by gavage, 150 mg/kg and 300 mg/kg of extract daily for 14 days. At 300 mg/kg, the two extracts (Terminalia superba and Canarium schweinfurthii), significantly showed at least 67.1% and 69.9% reduction in blood glucose level, respectively, while insulin (three units) given subcutaneously and once daily, had 76.8% reduction compared to diabetic untreated control rats. Similarly, the weight gains were 6.6% and 4.9%, respectively, and were comparable to the normal rats, whereas, diabetic untreated rats lost 14.1% body weight. Still with the same dose, there was 68.5% and 58.5% (p < 0.001) significant decrease in food consumption and 79.7% and 64.0% (p < 0.001) in fluid intake by diabetic rats treated with the respective plant extracts. The insulin-treated rats showed 56.4% and 75.8% decrease in food and fluid intake compared to an augmentation for diabetic control rats, 43.0% and 383.8%, respectively, at the end of the second week of experimentation. These results showed that the plant extracts can reverse hyperglycemia, polyphagia and polydipsia provoked by streptozotocin, and thus, they have anti-diabetic properties.
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PMID:Anti-diabetic activity of methanol/methylene chloride stem bark extracts of Terminalia superba and Canarium schweinfurthii on streptozotocin-induced diabetic rats. 1627 36

Human (visceral) obesity is associated with alterations hypothalamus-pituitary-adrenal (HPA) axis functioning. It is however not completely clear whether the HPA axis is causally or co-incidentally related to (visceral) obesity. This review summarizes supporting data of an involvement of the HPA axis in the development of (visceral) obesity. First, several DNA polymorphisms related to HPA axis functioning are correlated to the development of obesity. Second, chronic elevation of circulatory glucocorticoid concentrations, as in Cushing's disease, results in increased abdominal adiposity. Third, (visceral) obesity is associated with a diminished capacity of cortisol to suppress its own secretion. HPA axis functioning might affect energy balance through affecting energy intake. Both CRH and cortisol influence physiological, central mechanisms involved in the regulation of food intake. Still, general activation of the HPA axis has shown to have inconsistent effects on food intake in humans. This inconsistency may partially be explained by gender differences, individual differences in the functioning of the HPA axis, as well as differences in attitude towards eating. In particular, women with high scores on dietary restraint are prone to stress-induced hyperphagia. Dietary restraint scores, in turn, are positively correlated to basal and dexamethasone-suppressed cortisol levels, indicating a complex dual relationship between stress, HPA axis functioning, attitude towards eating and the risk for stress-induced hyperphagia. In the Western society, with chronically high ambient levels of stress and the availability of high caloric foods, this relationship may imply a risk for the development of (visceral) obesity and the metabolic syndrome.
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PMID:The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance. 1827 77

Extraverted children are hypothesized to be most at risk for over-serving and overeating due to environmental cues--such as the size of dinnerware. A within-subject field study of elementary school students found that extraverted children served themselves 33.1% more cereal in larger bowls (16-oz) than in smaller (12-oz) bowls, whereas introverted children were unaffected by bowl size (+5.6%, ns). However, when children were asked by adults how much cereal they wanted to eat, both extraverted and introverted children requested more cereal when given a large versus small bowl. Insofar as extraverted children appear to be more biased by environmental cues, this pilot study suggests different serving styles are recommended for parents and other caregivers. They should serve extraverts, but allow introverts to serve themselves. Still, since the average child still served 23.2% more when serving themselves than when served by an adult, it might be best for caregivers to do the serving whenever possible--especially for extraverted children.
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PMID:Extraverted children are more biased by bowl sizes than introverts. 2420 66

For a companion dog, the most important environmental factor is the owner, who is responsible for providing everything that is necessary for the health and welfare of the dog. Still, one of the most often compromised measures of an average companion dog is its body condition, with overweight and obese animals representing a growing welfare problem around the world. Using an extensive online survey that was distributed among Hungarian dog owners, we wanted to know whether those obesogenic factors that were identified mostly in high-GDP countries' pet dog populations would hold their relevance in a much lower average income country as well. We found several associations between the body condition of canine companions and various demographics, environmental and behavioral factors. Older dogs reportedly had an accelerating propensity for being overweight. Joint activity and performing dog sports both reduced the likelihood of being an overweight dog. Main food types also had significant associations with the body condition of dogs-meanwhile, the feeding of commercial dog food (kibble) and/or leftovers of human meals coincided with being overweight, dogs that were fed (fully, or at least partly) with raw food were less likely overweight. In the case of owner-reported behavioral problems, the food-related issues (stealing food, overeating, etc.) were clustered to a dimension together with problem behaviors such as excessive barking and overt aggression. Beyond showing a good agreement with earlier surveys on associated factors with canine obesity, our study revealed some interesting new details that could be used in the prevention of overweight problems in dogs.
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PMID:Factors Affecting Canine Obesity Seem to Be Independent of the Economic Status of the Country-A Survey on Hungarian Companion Dogs. 3272 90