Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the acutely diabetic rat, the polyphagia-induced increase in the weight of the small intestine is associated with reported increases in mucosal mass. Whereas, some of the individual mucosal components in the rat have been studied, comparable information for the acutely streptozotocin-diabetic mouse is lacking. A detailed morphological comparison of the epithelium of the small intestinal mucosa in control and untreated streptozotocin-diabetic mice was therefore undertaken. Samples from three small intestinal sites were examined by light and scanning electron microscopy and quantitative data obtained from histological sections. Although the morphological appearance of the small intestine in acutely diabetic mice was similar in many respects to literature accounts for the diabetic rat, infestation with filamentous microorganisms was present in the jejunum and ileum. The quantitative data showed that these sites also contained distorted villi, fewer crypt profiles, more goblet and Paneth cell profiles and a smaller epithelial volume in comparison to controls. These findings may represent differences between the rat and mouse models of streptozotocin-induced diabetes mellitus.
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PMID:A morphological study of the enteric mucosal epithelium in the streptozotocin-diabetic mouse. 936 32

We report a case of binge eating disorder (BED) in a 19-year-old Spanish woman, whose onset followed a nowadays uncommon parasitic intestinal disease (Taenia solium by cysticercosis). The patient exhibited bizarre and frequent hyperphagia episodes and extreme loss of weight, common symptoms of this condition. The patient continued to have frequent binge episodes and inappropriate eating patterns, gaining weight consequently over a normal range, despite successful treatment of the condition. No purging behavior was detected. A classical conditioning behavioral model, was useful for the understanding and formulation of this case. To the authors' knowledge, this is the first reported case where a parasitic infestation triggered the onset of BED.
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PMID:Binge eating disorder onset by unusual parasitic intestinal disease: a case-report. 1143 15