Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The anorexigenic 20 amino acid neuropeptide S (NPS) has not been studied in an animal model of hypo- or hyperphagia. The present study aimed to elucidate whether central NPS appetite-related effects are different in lines of chickens that had undergone long-term divergent selection for low (LWS) or high (HWS) body weight and that were hypo- and hyperphagic, respectively. It took a longer time for food intake to be reduced in LWS than HWS chicks administered the lowest dose of NPS tested (0.14 nmol) and, at the highest dose tested (0.56 nmol), they had a greater reduction in food intake than did HWS chicks. HWS chicks responded with a similar magnitude of food intake reduction that was independent of NPS dose. Although water intake was reduced concurrently with food intake after central NPS in both lines, blood glucose concentrations were not affected. Hypothalamic signalling was different between the lines. Although both lines respond to central NPS with decreased c-Fos immunoreactivity in the lateral hypothalamus, the periventricular nucleus had increased c-Fos immunoreactivity in LWS but not HWS chicks. After central NPS treatment, there was increased c-Fos immunoreactivity in the paraventricular nucleus in HWS but not LWS chicks. These data support the notion of differences in the central NPS system between the LWS and HWS lines and infer that central NPS may differentially affect appetite-related processes in other species that contain hypo- and hyperphagic individuals.
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PMID:Differential appetite-related responses to central neuropeptide S in lines of chickens divergently selected for low or high body weight. 1844 29

The recently discovered anorectic effect of neuropeptide AF (NPAF) has not been studied in hypo-and hyperphagia animal models. The present study was designed to examine possible differences in appetite-related effects after central NPAF administration in lines of chickens that had undergone long-term divergent selection for low (LWS) or high (HWS) body weight and exhibit hypo- and hyperphagia, respectively. LWS chicks responded at a similar magnitude of food intake reduction to all doses of NPAF tested at all observation times. HWS chicks had an increased latency (150 min versus 30 min post injection) and an increased dose threshold of response (8 nmol versus 2 nmol) than LWS chicks. Water intake of LWS chicks was reduced in all doses tested at all observation times, whereas HWS chicks responded to the three doses of NPAF tested up to 60 min post injection, after which the decrease was sustained only at a dose of 8 nmol. In a comprehensive behaviour analysis, exploratory pecks, food pecks and locomotion were significantly reduced in both lines by NPAF, whereas sit time was increased in both lines. Other behaviours, including stand time, deep rest time and escape attempts, were not affected. These data suggest that the threshold of NPAF-induced anorexia is lower in LWS than HWS chicks and that NPAF-induced anorexia is a primary effect in both lines, and also support the hypothesis that differences exist in the central NPAF system between hypo- and hyperphagic individuals.
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PMID:Neuropeptide AF differentially affects anorexia in lines of chickens selected for high or low body weight. 2023 26

Effects of intracerebroventricular (ICV) injection of calcitonin (CT) and calcitonin gene-related peptide (CGRP) on food and water intake were measured in two lines of White Plymouth Rock chickens from a common base population that have undergone long-term divergent selection for either low (LWS) or high (HWS) juvenile body weight. These lines contain anorexic and obese individuals and serve as models for hypo- and hyperphagia. For both ICV injection of CT and CGRP, line HWS responded to a lower dose with decreased food intake than did line LWS. Both peptides were also associated with reduced water intake in both lines. Although plasma glucose concentrations were inherently different between lines, neither CT nor CGRP affected these levels. Comprehensive behavior analyses were conducted and only the number of food pecks was differentially suppressed between lines after both CT and CGRP injection. Thus, the selection program may have caused alterations in the endogenous CT and CGRP systems that synergistically, with other neurotransmitter systems, contribute to the role of food intake on the differential body weights between these lines.
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PMID:Both calcitonin and calcitonin gene-related peptides' thresholds of hypophagia are considerably lower in chicks selected for high rather than low juvenile body weight. 2049 97

While neuropeptide Y (NPY) has been studied extensively per its pronounced role in food intake stimulation as well as its role in central pathways governing eating disorders, it has to our knowledge not been studied in polygenic models of hypo- and hyperphagia. Thus, the present study was designed to measure central NPY-associated food intake in lines of chickens that have undergone long-term genetic selection for low (LWS) or high (HWS) body weight and exhibit hypo- and hyperphagia, respectively. LWS chicks did not respond with any magnitude of altered food intake to any dose of NPY tested, while HWS chicks responded to all doses of NPY at similar magnitudes throughout the duration of observation. Both lines responded with similar increases in c-Fos immunoreactivity in the lateral hypothalamus and both divisions of the paraventricular nucleus; there were no significant line or line by treatment interactions. These data support the hypothesis that differences exist in the central NPY system of chicks from LWS and HWS lines and may provide novel insight for understanding NPY control of appetite.
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PMID:Neuropeptide Y is associated with changes in appetite-associated hypothalamic nuclei but not food intake in a hypophagic avian model. 2292 28