Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020505 (
hyperphagia
)
6,116
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Anorexia is a common manifestation of chronic diseases, including cancer. Here we investigate the contribution to cancer anorexia made by calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) that transmit anorexic signals. We show that CGRP
PBN
neurons are activated in mice implanted with Lewis lung carcinoma cells. Inactivation of CGRP
PBN
neurons before tumor implantation prevents anorexia and loss of lean mass, and their inhibition after symptom onset reverses anorexia. CGRP
PBN
neurons are also activated in Apc
min/+
mice, which develop
intestinal cancer
and lose weight despite the absence of reduced food intake. Inactivation of CGRP
PBN
neurons in Apc
min/+
mice permits
hyperphagia
that counteracts weight loss, revealing a role for these neurons in a 'nonanorexic' cancer model. We also demonstrate that inactivation of CGRP
PBN
neurons prevents lethargy, anxiety and malaise associated with cancer. These findings establish CGRP
PBN
neurons as key mediators of cancer-induced appetite suppression and associated behavioral changes.
...
PMID:Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus. 2868 Jan 63
