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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this paper the first case of Kluver-Bucy syndrome (KBS) in Huntington's chorea is reported. The patient, a 46-year-old man with advanced Huntington's disease, displayed prosopagnosia, oral tendencies, emotional changes, hypersexual behavior, and hyperphagia associated with severe dementia. Haloperidol in moderate doses controlled both the KBS and the chorea, suggesting a possible role for the dopaminergic system in the pathogenesis of KBS in Huntington's disease. The presence of profound dementia in our patient supports the previous assertion that human cases of KBS are invariably associated with severe cognitive dysfunction. Since KBS was established as an entity, a great deal of attention has been directed to its neuroanatomical basis. However, due to the multidetermined nature of human behavior, the role of physiological, psychological, and environmental factors should also be taken into consideration with regard to the pathogenesis of this syndrome.
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PMID:Kluver-Bucy syndrome in Huntington's chorea. 316 95

We examined 18 patients with problematic behaviors in relation to their individual characteristics and their possible relationship to certain aspects of dementia namely cognitive impairment, stage of illness, language impediment and functional disability. They formed part of an earlier assessment of 94 patients with dementia-related problems. Ten had altered eating habits and eight (8.5%) of them had hyperphagia. One exhibited an incomplete form of Kluver-Bucy Syndrome. Two had pathological stealing and one scatolia (smearing of faeces). The remaining had bizzare behaviors such as screaming and head banging. The majority of the patients were in the moderate category in relation to the four domains tested. The study revealed that behavioral problems in the more severe dementia becomes less of a problem to the caregivers and others. These behaviors could dramatically affect the social and interpersonal relationships resulting in community, family and caregiver burden.
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PMID:Some problematic behaviors in Alzheimer's dementia. 1125 Dec 39

We report a kindred with three cases of dementia. The proband presented with forgetfulness and personality changes at age 56, followed shortly thereafter by behavioral dyscontrol, hyperphagia, hypersexuality, delusions, illusions, disinhibition and double incontinence. Neuroimaging studies were consistent with frontotemporal dementia (FTD). In one allele, an arginine insertion at codon 352 in the presenilin 1 (PSEN1) gene was identified; no mutation was identified in the amyloid precursor protein or tau genes. We conclude that the clinical features of the Kluver-Bucy syndrome and FTD can be associated with PSEN1 mutations. Furthermore, presenilin analyses may be helpful to characterize kindreds with familial dementing illnesses regardless of the phenotype, particularly if no tau mutation is present.
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PMID:Familial frontotemporal dementia associated with a novel presenilin-1 mutation. 1205 27

A 51-year-old right-handed man developed hypersexuality after a second right temporal lobectomy to treat epilepsy. His hypersexuality started with increased marital intercourse and masturbation but he later downloaded child pornography. Hyperphagia and distractibility, other features of the Kluver-Bucy syndrome, also developed. Resection of the amygdala and/or temporal lobe neocortical areas that inhibit other limbic areas may contribute to the pathogenesis of hypersexuality. Neurological factors mitigate the criminal responsibility for hypersexual activity in patients with Kluver-Bucy syndrome. Most previously reported patients were never charged with a crime despite uninvited physical contact in some instances. Our patient was convicted and imprisoned.
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PMID:Kluver-Bucy syndrome, hypersexuality, and the law. 1992 60

The characteristic behavioural constellation of Kluver-Bucy syndrome is believed to be diagnostic of bilateral temporal lobe damage, even in the partial syndrome. The case described is that of a 54 year old woman with gross atrophy of her right temporal lobe following neurosurgery who developed hyperphagia (with driven food-seeking behaviour), placidity and hyposexuality. Her case thereby meets criteria for the partial syndrome but without evidence of bilateral damage. The discussion covers the various presentations of hyperphagia, the significance of the symptom cluster of Kluver-Bucy syndrome and the management difficulties presented by hyperphagia.
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PMID:Unilateral temporal lobe damage and the partial Kluver-Bucy syndrome. 2448 27