Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Kleine-Levin syndrome (KLS) is an episodic hypersomnia with cognitive disturbances such as confusion, apathy, and derealization. Hyperphagia and hypersexuality occur in around 50% of cases. No evidence-based treatments have been established for KLS. Many drugs have been tried, most often with little success. Here, a case with a striking response to lithium is presented.
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PMID:A striking response to lithium in kleine-levin syndrome. 2471 3

Kleine-Levin syndrome is a rare recurrent encephalopathy primarily affecting teenagers, characterized by relapsing-remitting episodes of hypersomnia along with cognitive, psychiatric and behavioral disturbances. During episodes, patients suddenly present hypersomnia (with sleep lasting 15-21 h/d), cognitive impairment (major apathy, confusion, slowness, amnesia), and a specific feeling of derealization (dreamy state, altered perception). Less frequently, they may also experience hyperphagia (66%), hypersexuality (53%, principally men), depressed mood (53%, principally women), anxiety, hallucinations, and acute brief psychosis (33%). Brain functional imaging is often abnormal. Stimulants are poorly beneficial during episodes, whereas lithium and valproate help reducing the episodes frequency and duration.
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PMID:Kleine-Levin Syndrome. 2605 63