Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An acrodermatitis enteropathica-like syndrome occurred as a result of severe bowel disease and the use of zinc-deficient hyperalimentation regimens. Emphasis is placed on early and adequate zinc replacement to effectively prevent or reverse this entity.
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PMID:The acrodermatitis enteropathica-like syndrome. 10 49

Zinc is an essential trace element whose malabsorption in early childhood may result in a skin disorder known as acrodermatitis enteropathica. Cutaneous lesions typical of acrodermatitis enteropathica have been described during total parenteral nutrition on zinc-deficient intravenous solutions in both adults and children. This condition has been named the "acute zinc depletion syndrome." A case is described in which a patient, despite a zinc intake of double the daily requirement, manifested the acute zinc depletion syndrome during therapy with combined liquid diet plus parenteral hyperalimentation. Predisposing factors in this individual included a short bowel syndrome and a large oral load of calcium lactate. Zinc metabolism is reviewed with attention to alterations in disease and during hyperalimentation. The clinical manifestations, predisposing factors, therapy and prevention of the acute zinc depletion syndrome are discussed.
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PMID:Acute zinc depletion syndrome during parenteral hyperalimentation. 11 98

Two patients, who were on long term parenteral hyperalimentation, developed skin lesions similar to those seen in acrodermatitis enteropathica. Both patients were treated with oral zinc sulphate and their skin lesions cleared completely. These patients are presented as an acquired zinc deficiency syndrome.
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PMID:Acquired zinc deficiency disease of skin. 40 84

In this paper two patients with uncommon syndromes, viz. acrodermatitis enteropathica-like eruption due to acute zinc deficiency, when on long-term intravenous hyperalimentation for Crohn's disease, and necrolytic migratory erythema as a consequence of a malignant glucagon secreting alpha-cell tumour of the pancreas (glucagonoma syndrome) are reported. Attention is paid to the many common features of the skin lesions in both syndromes. This is discussed in detail. Both patients passed through a catabolic stage. Laboratory investigations, however, failed to demonstrate a common biochemical mechanism which might be responsible for the skin lesions. Administration of zinc in the first patient and surgical treatment of the second patient results in rapid clearing of the skin lesions and other symptoms.
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PMID:Zinc deficiency syndrome versus glucagonoma syndrome. 53 35

Of 54 patients who received prolonged intravenous hyperalimentation during the past 4 years, six developed progressive, characteristic skin lesions. These cutaneous manifestations frequently were accompained by abdominal symptoms resembling those of acrodermatitis enteropathica in many respects. In the first four of these six patients, skin eruptions disappeared promptly after the initiation of oral feeding, which led us to assume that these skin manifestations are due to some unknown nutrient deficiency. Our experience in the remaining two patients enabled us to presume the underlying pathology to be zinc deficiency.
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PMID:Skin lesions during intravenous hyperalimentation: zinc deficiency. 82 54

Acrodermatitis enteropathica has been reported as the skin disorder due to the congenital disturbance of zinc absorption in the intestine. We report on three patients with skin eruptions that resembled acrodermatitis enteropathica. Two were thought to have resulted from intravenous hyperalimentation and the other from artificial feeding.
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PMID:Zinc deficiency: report of three cases. 193 43