Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two-hundred and sixty-four patients with typhoid perforation of the bowel, who were admitted to our department during a five-year period (1978 to 1982) were reviewed. Most of the patients presented with advanced peritonitis, severe dehydration, toxemia and gross malnutrition. History and clinical examinations were sufficient for the diagnosis of these patients. Operative management was found to be far better than conservative treatment which was associated with a very high mortality. The best morbidity and mortality levels were obtained in patients who received thorough peritoneal lavage, intravenous Metronidazole, hyperalimentation and blood transfusion. The single layer suture technique was found more effective in reducing the incidence of postoperative fecal fistula than the double layer technique.
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PMID:Typhoid bowel perforation: a review of 264 cases. 650 Aug 81

An 81-yr-old male with pulmonary emphysema was hospitalized because of malnutrition and hypoglycemia. This patient developed ventilatory failure requiring mechanical assistance 12 h after initiation of iv hyperalimentation. Severe hypophosphatemia (0.1 mg/dl), mild hypocalcemia, hypomagnesemia, and hypokalemia were subsequently and concomitantly documented. Repeated attempts to wean him from the respirator failed until hypophosphatemia was corrected. When difficulties are encountered in weaning patients from mechanical ventilation, attention should be directed toward detection of hypophosphatemia. This may be crucial in the presence of chronic lung disease.
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PMID:Hypophosphatemia as a reversible cause of refractory ventilatory failure. 662 64

The nutritional situation of the elderly is characterised on the one hand by changes in nutrient requirements resulting from increased age and on the other hand by altered nutritional needs. Faulty eating habits, malnutrition as well as overeating are not uncommon. Experimental research in spontaneous feeding behavior lead to the conclusion that not only is the modifiability of food intake through environmental stimulation reduced in the elderly, but also the efficiency of internal cues through which the degree of satiety is experienced. Investigation of taste and smell in which a total reduction of sensory capacity was ascertained, point in the same direction: sensory deficits have a cumulative effect on the appetite of the elderly. An increased reliance on habit and rational as well as pseudo-rational eating rules was observed on the part of the elderly. Indications for praxis are derived from these observations which are discussed in the context of a theoretical concept.
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PMID:[Eating behavior in the elderly and its consequences for nutrition]. 664 64

Anorexia nervosa (AN) can be considered a result of complex instrumental conditioning. It is postulated that in healthy nonsatiated individuals, the sight and smell of the preferred food, acting as a conditioned stimulus (food CS), activates a memory pattern of associations "eating--desirable sensory input" (approach pattern). This leads to the instrumental reaction of eating which is reinforced by sensory satisfaction. In victims of AN, in addition to the approach pattern the food CS activates another pattern of associations consisting of such components as "eating--obesity--failure" and " noneating --thinness--success" (avoidance pattern). The establishment of the avoidance pattern depends on such factors as social preferences and pressures to be slim, inborn dispositions, and personal psychological problems. If the activation of the avoidance pattern prevails over the activation of the approach pattern, the individual refrains from eating. The refusal to eat is here an instrumental avoidance reaction; its performance is reinforced by satisfaction derived from successful self-control and losing weight. A prolonged activation of the avoidance pattern leads to malnutrition and ultimately to death. In cases in which the approach pattern and the avoidance pattern are frequently activated simultaneously to the same degree, a neural conflict may develop. In a variation called "bulimia nervosa," an activation of the approach pattern alternates with the activation of the avoidance pattern. First, overeating takes place; it is reinforced by oral-gastric satisfaction. Then, the avoidance reaction of self-induced vomiting or purging follows; it is reinforced by satisfaction derived from preventing weight gain.
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PMID:Anorexia nervosa as a case of complex instrumental conditioning. 672 79

A technique for prehepatic infusion of parenteral nutrients is described. Portal vein hyperalimentation allows hepatic modification and control of the infused nutrients before delivery of these substances into the general circulation and theoretically should reduce the incidence of metabolic complications of hyperalimentation. The clinical experience with prehepatic infusions is reported and the metabolic investigations are described. Transumbilical catheters provided prehepatic delivery of parenteral nutrients for 1 month after esophagogastrectomy for esophageal malignancy without serious infection or portal vein thrombosis. Close surveillance of blood glucose and serum osmolarity demonstrated metabolic stability during the infusion period. Nitrogen balance studies showed better nitrogen economy than is achieved by infusion of similar solutions into the central systemic circulation. Indirect calorimetry indicated that the nitrogen used for production of energy was less than the amount supplied by prehepatic infusions. The same basic liver function abnormalities encountered with systemic infusion of hyperalimentation solutions were noted. The patients gained weight after esophagogastrectomy and did not experience the attrition from malnutrition which usually occurs in the first several months after esophageal resection.
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PMID:Prehepatic hyperalimentation. 676 87

Hyperalimentation can improve nutrition in patients with cancer. It has proved to be effective in the management of certain postoperative complications. Some patients are able to receive antitumor therapy who would otherwise be denied treatment because of severe malnutrition. The morbidity of chemotherapy and radiation therapy may be decreased, delivery of greater doses of chemotherapy is possible and responses to chemotherapy may be enhanced. Hyperalimentation can reverse the nutritional components of the immunodepression of malignant disease. Although it may stimulate tumor growth in animals, hyperalimentation has had no adverse clinical consequences to date.
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PMID:Hyperalimentation in patients with cancer. 676 44

Management of protein-calorie malnutrition found in 32 patients with severe liver diseases such as fulminant hepatitis and cirrhosis of the liver was carried out using 2 types of synthetic amino acid solution (Hep-OU and Fischer solution) for intravenous and enteral alimentations with rapid monitoring of serum aminogram. Intravenous hyperalimentation of these cases resulted in maintenance of nutritional status with improvement of nitrogen balance and normalization of impaired serum aminogram. During this study, however, nutritional support was initiated only when intractable ascites, upper gastrointestinal bleeding and hepatic encephalopathy were observed. In 2 cases of fulminant hepatitis with sepsis and 3 hepatoma patients with ascites, elemental diet containing maltose and amino acids was used to supply sufficient amounts of nutrients in a minimum volume of water. These techniques with simultaneous monitoring of urinary excretion of 3-methylhistidine and creatinine height index as nutritional parameters make nutritional management easy for patients with liver disease.
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PMID:Nutritional management of patients with severe liver disease by using intravenous hyperalimentation and elemental diet. 676 41

The effect of intravenous hyperalimentation on the nutritional status of 84 cancer patients treated at the Istituto Nazionale Tumori, Milan, has been evaluated. The body weight increased in 78% of patients, mid upper arm circumferance in 93%, triceps skinfold in 73%, mid upper arm-muscle circumference in 73%, creatinine/height index in 30%, serum albumin in 32%, transferrin in 35%, total peripheral lymphocytes in 38%. Lymphocyte blastogenesis increased in 74% of the patients examined and skin tests were converted from negative to positive in about 20% of patients. In addition 8 our of 18 patients responsive to IVH benefited from chemotherapy and/or radiotherapy indicating that the nutritional repletion of the host did not significantly affect the growth of the tumor. These findings support the opinion that neoplastic cachexia may depend partially on malnutrition and can be often reversed by IVH. Moreover, IVH might have an adjunctive role as potentiator of chemotherapy which however must be confirmed by clinical trials.
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PMID:Effect of supportive intravenous hyperalimentation on the nutritional status of cancer patients. 677 22

Immunocompetence was measured in 320 gastrointestinal surgery patients using the delayed hypersensitivity test. The frequency of complications and death from sepsis was greater (p less than 0,001) in anergic patients (39%) than in patients with normal response (5%). A close correlation was observed between anergy and malnutrition as determined on the basis of biological criteria (triceps skinfold, arm circumference, ratio between actual and deal weights). This double correlation led to study the influence of hyperalimentation on immune response and prognosis. Parenteral hyperalimentation with nitrogen and calories was administered to 26 anergic patients with heavy or complicated intestinal surgery (peritonitis) for from 10 to 37 days (av.: 19, 2 days). One or more test(s) had turned positive by the 10th day in 7 patients; by the 30th day in 16 and by the 69th day in 20. Out of 26 anergic patients, 19 were nutritionally normal; hyperalimentation had no influence on biological criteria and began to modify body measurements only after 17 days; in the 16 anergic malnourished patients,, hypernutrition led to the development of a positive nitrogen balance (3,60 +/- 1,7 days) and to a return within normal range of biological criteria (7,2 +/- 2,3 days), and body measurements (14,3 +/- 9,2 days). Death from sepsis in anergic patients with hyperalimentation was lower (11,2% and 44,4%; p less than 0,01) than in anergic ones without hyperalimentation. Hyperalimentation with nitrogen and calories modified the nutritional status, immunological response and improved prognosis in anergic patients.
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PMID:[Hyperalimentation after digestive surgery: influence on immune state and on prognosis (author's transl)]. 678 Sep 72

Twenty-three adult patients with protein-calorie malnutrition were referred for outpatient tube feeding. Initial nutritional support with hypercaloric supplemented diets did not prevent further catabolism and weight loss, as the mean protein intake was 35.2 g/24 hr and the mean calorie intake was 844 cal/24 hr. Outpatient tube feeding was then initiated in deliver a mean of 78.5 g protein/24 hr and 2248 cal/24 hr. Patients on tube feeding demonstrated an increase of serum albumin and total body weight compared to diet therapy alone. The patient and family members were instructed in the technique of outpatient enteral feeding, which included instructions in feeding tube intubation, formula aspiration, and monitoring methods to prevent gastric aspiration and pooling. No major complications were observed. Home tube feeding was concluded to be a safe, efficient, and relatively inexpensive method of hyperalimentation for selected patients.
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PMID:Home tube feeding for long-term nutritional support. 678 79


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