Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Six hundred fifty-four peripheral Teflon catheters in 303 pediatric intensive care unit patients were examined to determine complication rates and associated risk factors. Phlebitis, extravasation, and bacterial colonization occurred at rates of 13%, 28%, and 11%, respectively. Logistic regression of factors that increased phlebitis risk revealed infusion of hyperalimentation (odds ratio 2.9) or lorazepam (odds ratio 2.2) and catheter location (odds ratio 2.9) as the most important determinants of phlebitis risk. Age (less than or equal to 1 year, odds ratio 2.0), catheter time in situ (less than or equal to 72 hours, odds ratio 2.1), and infusion of antiepileptics (odds ratio 2.1) were the most important determinants of extravasation. Catheters were colonized most frequently with coagulase-negative Staphylococcus (51/54). Sepsis attributable to catheter colonization occurred in 1 patient. Duration of catheter placement (greater than or equal to 144 hours, odds ratio 5.8) was an important determinant of catheter colonization. Colonization risk increased from 11% in catheters that were in situ for 48 to 144 hours to 34% for catheters that were in for longer than 144 hours. Infusion of diazepam (odds ratio 11.0) or lipid emulsions (odds ratio 2.5) and age (less than or equal to 1 year, odds ratio 2.2) were also important determinants of colonization risk. Replacing catheters in critically ill children every 72 hours would not decrease phlebitis, bacterial colonization, or catheter-induced sepsis and could increase extravasation risk. Catheters can be safely maintained with adequate monitoring for up to 144 hours in critically ill children.
 ...
PMID:Peripheral intravenous catheter complications in critically ill children: a prospective study. 159 67

We found clinical phlebitis in 57 of 88 patients with peripheral hyperalimentation (65%). To determine if this was a problem common to all intravenous fluid therapy at our hospital, we performed a point-prevalence study. The prevalence of phlebitis in nonhyperalimentation intravenous patients was 18% (84 of 456 patients). We then performed a randomized, prospective, double-blind trial of sham versus standard in-line filters to determine if bacteria or filterable particulate matter was responsible for phlebitis in the peripheral hyperalimentation group. The standard-filter group had a phlebitis rate of 74% compared with 64% in the sham-filter group. We then eliminated in-line filters and replaced the standard glucose-based solution with a glycerol-based peripheral hyperalimentation solution. The phlebitis rate decreased from 68% to 27% (p less than 0.001). In conclusion, phlebitis in peripheral hyperalimentation patients was probably due to chemical properties of the peripheral hyperalimentation solution rather than bacteria or particulates.
 ...
PMID:Three-phase study of phlebitis in patients receiving peripheral intravenous hyperalimentation. 210 70

An infant, born with multiple anomalies of the gastrointestinal tract, required intravenous hyperalimentation for virtually his entire life. His course was characterized by multiple episodes of sepsis or phlebitis, culminating in death five and one-half months after birth. The brain and spinal cord at necropsy were normal on gross inspection. However, microscopic study showed inflammation of the dura surrounding the spinal cord with sparing of the spinal and cerebral subarachnoid spaces.
 ...
PMID:Primary epiduritis. 679 49

While the numerous complications of intravenous hyperalimentation (IVH) are well recognized, we encountered a unique one. A 60-year-old man developed a sore throat, neck pain and fever seven days after catheterization of the subclavian vein to provide post-operative nutrition. Marked swelling was visible at the right posterior wall of this oropharynx and hypopharynx. X-ray of the neck revealed that the tip of the catheter was positioned in the internal jugular vein, not the subclavian vein as intended. The acute pharyngitis, diagnosed as due to phlebitis of the internal jugular vein due to the malpositioned catheter, subsided within two days of catheter removal.
 ...
PMID:Acute pharyngitis, an unusual complication of intravenous hyperalimentation. 816 21

A national survey of neonatal intensive care units (NICUs) was undertaken to obtain information concerning drug usage, dosages, methods of administration, incidence of drug-induced phlebitis, and drug reference sources. Antimicrobial agents are the most frequently used drugs in NICUs. Dosages reported by NICUs generally agreed with dosage recommendations by the manufacturer and literature citations. A 10% estimate of phlebitis was the consensus report by NICUs. Calcium gluconate was implicated most often as causing phlebitis, and most NICUs reported that drugs are not mixed with hyperalimentation solutions. The Pharmacy and Therapeutic Committee should review drug dosages in neonates and establish policies for intravenous drug administration methods and rates to ensure uniform initial doses and to provide a consensus among clinicians using these medications.
 ...
PMID:Drug usage in newborn intensive care units. 1026 Feb 1