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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Debilitating cancer cachexia is multifactorial, but many of the etiologies and most of the resulting effects are similar to those seen in malnourished patients without cancer. From the work in human beings and experimental animals, nutritional support of the tumor-bearing host can replenish lean body mass, visceral protein components, and immunocompetence. This induction of anabolism, however, depends on time, content, the method of administration of hyperalimentation solutions; the initial and continuing catabolic response of the patient, as well as the degree of initial malnutrition; the energy expenditure of the patient required during oncologic therapy; and the expertise of the physician administering nutritional support. Increased tumor stimulation resulting from intravenous hyperalimentation (IVH) has never been observed in humans; the stimulatory effects of IVH on animal tumor systems have been identified only in previously depleted animals, and then growth rates have not been out of proportion to that of the host or to that of otherwise healthy animals. Animal data suggest that tumor growth characteristics can be affected by nutritional state and the exact substrates administered, ie, amino acids, carbohydrates, or fat. Further evidence suggests that the apparent enhanced tumor growth can be used to increase responsiveness to cell cycle-specific chemotherapeutic agents during nutritional repletion. Current evidence supports the use of intravenous hyperalimentation in malnourished cancer patients who have effective oncologic therapeutic options; such patients should not be denied these options simply on the basis of severe nutritional cachexia.
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PMID:Intravenous hyperalimentation as nutritional support for the cancer patient--an update. 393 74

Reduced serum concentrations of nutrients like iron, zinc and folates and of albumin and cholesterol are found, as well as emaciation, both in malnutrition and in cancer. In patients with leukemia, a depletion of intracellular potassium and hypo-potassemia are found in addition. The use of hyperalimentation in cancer was originally based on the concept that too little food is the cause of these disturbances in the nutrition state. However, there is also a disturbed metabolism of nutrients in patients with tumors and inflammatory disease. In the case of folic acid, the disturbed metabolism could not be normalized by hyperalimentation. The more advanced the disease, the more pronounced is the disturbed nutrient metabolism, and this disturbance is related to the macrophage activity. It is not self-evident, therefore, that hyperalimentation can normalize the nutritional state in cancer. Emaciation in cancer patients is not caused exclusively by malnutrition.
Med Oncol Tumor Pharmacother 1985
PMID:Folate and iron metabolism in patients with tumors and inflammations. 406 5

A case of bilateral angiomyolipoma which was complicated with retroperitoneal massive hemorrhage and in which right-nephrectomy was performed is reported. Eight years ago, this patient had tuberous sclerosis and underwent open renal biopsy with which the diagnosis was confirmed. This patient was admitted for shock caused by the retroperitoneal massive hemorrhage from tumor. For about 30 days, the patient was treated conservatively, such as blood transfusion and hyperalimentation, but retroperitoneal massive hemorrhage reoccurred and the patient underwent right-nephrectomy. The treatment for bilateral angiomyolipoma complicated with retroperitoneal massive hemorrhage is discussed.
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PMID:[Management of hemorrhage secondary to renal angiomyolipoma]. 409 Nov 26

This review article touches on various categories of research that have been expanded or made possible predominantly by funding through the National Cancer Program of the National Cancer Institute and the American Cancer Society. Under diagnosis, categories mentioned are biological markers, chromosome banding techniques, fluorescent-activated cell sorter identification of cell surface antigens, ultrastructural studies with electron microscopy, histochemical, radiologic, ultrasonographic, thermographic, angiographic techniques, nuclear magnetic resonance imaging, radioactively labeled compounds that attach to specific tumor cell surface receptors, and other agents that are preferentially taken up by tumor tissues. Predictive tests include human tumor stem cell assays, sister chromatid exchange assay, and hormone receptor assays. The techniques listed under therapy include hyperthermia, immunotherapy, chemotherapy, radiosensitizing compounds, and the supportive measures of hyperalimentation and other nutritional manipulations, psychological reinforcement, rehabilitative efforts, bone marrow transplants, blood component therapy, protective "germ-free" environments, and pain control. Drug delivery systems, animal and cell culture models, and prevention of carcinogenesis are also mentioned.
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PMID:Cancer 1980: achievements, challenges, and prospects. 617 12

Patients with gastric cancer undergoing surgery have much to endure and are accompanied by many risks. These risks depend on localization and extent of the tumor, the patients' general condition (nutritional and immune status), age, coexistent diseases and the extent of the required operation. In view of these facts, the principle of radical surgery must be weighed against the tolerance capability of the patient, especially in old people. Extensive diagnostic procedures are necessary to explore those risks. The preoperative treatment (hyperalimentation), the well considered indication for surgery, the choice of operation with lowest risk and the perioperative measurements are of great importance in limiting the risk for the patient.
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PMID:[Stress tolerance of the patient in abdominal surgery: stomach cancer]. 620 16

The continuous intravenous administration of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) to colorectal cancer patients was studied in regard to the stability of FT in intravenous hyperalimentation (IVH) solutions and tumor levels of 5-fluorouracil (5-FU). FT was very compatible with IVH solutions, because the decomposition of FT in IVH solution was very low, 3%. High levels of 5-FU, which is an active metabolite of FT, were obtained in the tumors, averaging 0.369 mcg/g. The ratios of 5-FU levels in the tumor to those in serum and normal tissues were 13.6 and 3.7, respectively. The difference in 5-FU levels between normal tissues and the tumors was statistically significant (P less than 0.01). Therefore, continuous intravenous administration of FT should be widely used to treat patients with colorectal cancer, as the method of administration of antitumor agents.
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PMID:Continuous intravenous administration of 1-(2-tetrahydrofuryl)-5-fluorouracil [FT] by intravenous hyperalimentation (IVH)--stability of FT in IVH solution and tumor levels of 5-fluorouracil (5-FU). 640 40

In carcinoma of the esophagus, response to in vivo sensitization with recall antigens and DNCB was markedly depressed with 13% and 16% positivity respectively. Similarly, the number of T-cells was found to be significantly low (24 +/- 14) as compared to normal control (61 +/- 23). Blastogenesis index with PHA was only 1.75 +/- 1.04 in contrast to normal of 6.79 +/- 2.57. This depression was independent of serum albumin level and body weight. Cell-mediated immunity was further depressed following radiotherapy and did not improve following enteral alimentation for 3 weeks. In untreated patients, there was a significant rise in levels of IgA (298 +/- 184 mg/100 ml) as compared to normal (154 +/- 54 mg/100 ml). Levels of IgA did show a downward trend following enteral hyperalimentation. Circulating immune complexes and serum CEA level were elevated in almost 50% of patients. These data confirm the influence of tumor-related impairment of cell-mediated immunity while nutrition appears to affect IgA levels.
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PMID:Immunity in esophageal carcinoma. 641 76

Two studies were conducted to measure the metabolic influence of tumor growth in rats. Parameters for the metabolic state were wound-healing qualities of colon and skin. Both early and later stages of tumor growth lowered wound healing qualities to a statistically significant degree. No anorexia or weight loss was found in this rat-tumor model during the study period. Intravenous hyperalimentation (IVH; with proteins and carbohydrates) of tumor-bearing rats stimulates tumor growth but at the same time restores wound-healing qualities to control levels, both during early and later stages of tumor growth. It is suggested that tumor growth leads to an as yet not measurable disturbance of the metabolic equilibrium but that IVH can replenish the tumor-bearing host and restore the metabolic equilibrium.
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PMID:The influence of intravenous hyperalimentation (IVH) on wound healing in tumor-bearing rats. 641 78

A nutritional support team was used in the assessment and management of patients on a general urological service. Indications for nutritional evaluation included history of weight loss, anorexia, significant infection, chronic neoplastic disease, trauma or major surgery. The fat and protein status of the patient was assessed by anthropomorphic and laboratory determinations. The patient then was categorized as having mild, moderate or severe degrees of nutritional depletion. Deficiencies in vitamins, trace elements or essential fatty acids were not noted. Caloric and protein needs were calculated by multiplication of the basal energy expenditure by a metabolic activity factor, which was derived from the degree of illness or stress. Nutritional support was provided by enteral feedings via oral, nasogastric or jejunal feeding tubes and/or intravenous hyperalimentation via peripheral or central venous nutrient lines. During a 6-month interval nutritional consultation was requested for 50 patients, who represented 7 per cent of the urological admissions. Nutritional support was provided for patients who had obstructive uropathy with or without neoplasms, radiation cystitis, sepsis, urinary fistulas, mental depression, end stage renal disease or neurological dysfunction. In patients in whom urological treatment controlled the disease nutritional support maintained the weight, and stabilized serum albumin and lymphocyte counts. We concluded that a nutritional support program has a significant and, often, unappreciated role in the management of urological patients.
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PMID:Nutritional support in a general urological service. 642 56

Changes in erythrocyte polyamine levels during intravenous hyperalimentation in cancer and noncancer patients were determined, and the influence of host nutritional status on polyamine metabolism was analyzed. RBC putrescine (P less than .001), spermidine (P less than .01), and spermine (P less than .005) levels, and the putrescine-spermidine ratio (P less than .001) increased in the cancer group while no significant increases were noted in the noncancer group. The degree of malnutrition, based on body weight loss and plasma albumin, transferrin, prealbumin, and retinol-binding protein levels, was significantly greater in the cancer group than in the noncancer group, giving rise to the possibility that repletion of nutritional deficits in host tissues could have contributed to the rise in RBC polyamines. When cancer patients of similar nutritional status were matched with the noncancer group, increases in RBC putrescine level and putrescine-spermidine ratio were noted in the selected cancer patients. These results suggest that correction of nutritional deficits did not contribute significantly to the RBC polyamine pool and that increases in RBC polyamines during intravenous hyperalimentation were related to the presence of tumor.
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PMID:Nutritional parameters affecting erythrocyte polyamine levels in cancer patients. 643 45


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