Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Plasma concentrations of 25 essential (EAA) and nonessential (NEAA) amino acids were measured pre- and postdialysis in 46 chronic hemodialysis therapy (CDT) patients. Sixteen of these patients with prior weight loss of 14.5 +/- 2.37 pounds in 24 months were administered a GAA solution (EAA + NEAA + glucose) for 20 weeks during each dialysis. Eight of these patients (group 1) responded with improved appetite and weight gain; the remaining eight patients (group 2) with clinically advanced metabolic bone disease continued to lose weight. Five other patients (group 14), biochemically similar to group 1 but with shorter prior dialysis experience, who received EAA (plus glucose) hyperalimentation (including oral I-histidine), experienced weight gain similar to group 1 but displayed significantly different plasma aminograms indicating a deficit of NEAA. When EAA and glucose hyperalimentation was administered without histidine (1 patient) no weight gain occurred and aminograms differed significantly from other groups. Plasma aminograms of 25 weight-stable, nonhyperalimented CDT patients were obtained for comparison. Results indicate GAA hyperalimentation can promote weight gain in catabolic CDT patients with inadequate prior nutritional intake (as in groups 1 and 14) but cannot reverse weight loss when the primary clinical setting is advanced metabolic bone disease and myopathy due to hyperparathyroidism (group 2). Hyperalimentation with glucose and an amino acid solution specifically tailored to the needs of CDT patients may improve results. Plasma phosphoethanolamine levels, normal for weight-stable and elevated in catabolic CDT patients, suggest a possible role for phosphoethanolamine as a marker for catabolism.
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PMID:Prolonged hyperalimentation in catabolic chronic dialysis therapy patients. 680 Dec 81

The Weigert-Meyer rule predicts the draining pattern of duplex ureters in bipolar renal duplications. This paper introduces two cases of nonpolar renal duplication. A 3-month-old and a 15-year-old female with history of urinary tract infection were evaluated with intravenous pyelograms (IVP) and eleven different parameters were analyzed. The infant's IVP showed an unobstructed side-to-side right renal duplication with normal-sized nondisplaced lateral moiety and a complete set of calyces, without drooping lily sign. The nonobstructed moiety projected medial and mildly inferior to the lateral moiety which had normal height and axis. The ureters joined each other in lower abdomen. Severe platyspondyly was noted due to hyperalimentation-induced metabolic bone disease. The second case had an unobstructed interpolar extra moiety between the upper and the lower poles with an otherwise unobstructed, normally sized single-system kidney, without drooping lily sign. The paradigm shift from classic anatomic to contemporary cell biological theory validates the nonpolar renal duplication concept, with side-to-side and interpolar arrangements of the moieties, in defiance of Weigert-Meyer rule.
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PMID:Side-to-side and interpolar renal duplications: the nonpolar variety. 2338 2