Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seven patients developed severe zinc deficiency with acrodermatitis during hyperalimentation. Several of them had other problems such as diarrhea, poor wound healing and mental changes, which may also have been related to zinc deficiency. Three patients were on hyperalimentation for 2 weeks or less when skin lesions first developed, and most patients were receiving regular infusions of plasma. All patients responded to enteral administration of zinc. We conclude that: 1) severe zinc deficiency with acrodermatitis is not a rare complication of hyperalimentation; 2) even short-term hypralimentation may be complicated by severe zinc deficiency with acrodermatitis; 3) plasma is not an appropriate way to provide zinc supplementation; 4) if intravenous zinc preparations are not available, oral supplementation is usually effective; and 5) all patients undergoing hyperalimentation should receive zinc supplementation and have regular monitoring of their serum zinc level.
 ...
PMID:Severe zinc deficiency presenting with acrodermatitis during hyperalimentation: diagnosis, pathogenesis, and treatment. 677 23

Two patients developed severe zinc deficiency with acrodermatitis during parenteral hyperalimentation. The response of circulating T-lymphocytes to phytohemagglutinin was assessed both during the episode of clinical zinc deficiency and after intravenous zinc supplementation as the sole means of nutritional intervention. Maximum T-cell response to phytohemagglutinin, expressed as percent of simultaneous normal control response, was 2.1% and 27.9% in Patients 1 and 2 respectively. After 20 days of intravenous zinc supplementation (12 mg/d), repeat studies showed the T-cell response of Patient 1 to be 221% of the control, and that of Patient 2 to be 139% of control. In addition, Patient 1 was anergic during the period of zinc deficiency and normally reactive after zinc supplementation. These findings agree with extensive animal studies showing the detrimental effect of zinc deficiency on cellular immunity.
 ...
PMID:Severe zinc deficiency in humans: association with a reversible T-lymphocyte dysfunction. 678 37