Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pancreatic fistulas can be internal or external and the consequence of acute or chronic pancreatitis, malignancy, or trauma (to include pancreatic surgery, pseudocyst drainage, and percutaneous biopsy). Contingent on the presence of concomitant pseudocyst, downstream ductal obstruction, or a disconnected duct syndrome, treatment may include maneuvers to decrease pancreatic secretion (NPO, hyperalimentation, pancreatic enzymes, octreotide), attempts to effect serosal apposition (diuretics, thoracentesis, paracentesis), various types of percutaneous tube manipulation, or surgery. Transpapillary pancreatic duct stents have recently been used for refractory ductal leaks and may work either by direct occlusion of the fistula or by lowering the duodenal-pancreatic pressure gradient.
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PMID:Pancreatic fistulas: etiology, consequences, and treatment. 895 97

Although ductal disruptions are common in persistent, smoldering pancreatitis, pancreatic necrosis, or acute pancreatic fluid collections, chronic pancreatic fistulas have traditionally been defined as internal or external. Closure of these fistulas depends upon site and size of duct disruption, superinfection, downstream obstruction as a consequence of stricture or stone, or the presence of the "disconnected duct syndrome." Medical treatment is aimed at minimizing pancreatic secretion (low fat diet, pancreatic enzymes vs. NPO/hyperalimentation, octreotide, repeated/chronic drainage procedures). Resective or decompressive pancreatic surgery requires preoperative ERCP to define the anatomy. More recently, transpapillary endoprostheses have been used in a patient subset and deserve additional consideration in patients who fail to respond to conservative measures.
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PMID:Endoscopic therapy of complete and partial pancreatic duct disruptions. 940 50