Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020500 (hyperoxaluria)
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Human Gene/Protein
Sulfate anion transporter 1 15.1
L-alanine:glyoxylate aminotransferase 12.9
alanine-glyoxylate aminotransferase 12.6
SLC26A6 12.5
CFEX 12.4
GRHPR 12.4
AGXT 12.3
sulfate anion transporter 12.3
PH1 11.6
PRODH2 11.6
SAT-1 11.5
serine:pyruvate aminotransferase 11.2
Alanine:glyoxylate aminotransferase 11.1
NaDC-1 11.1
Alanine-glyoxylate aminotransferase 11.1
CFHR4 11.0
alanine:glyoxylate aminotransferase 11.0
major histocompatibility class II antigen 10.8
nuclear pore complex protein 10.7
hydroxypyruvate reductase 10.6
fetuin B 10.6
RASSF7 10.4
Kynurenine aminotransferase 10.3
DTDST 10.3
PH2 10.2
SLC26A5 10.0
glycolate oxidase 9.5
Glycolate oxidase 9.5
AGT1 9.4
NaSi-1 9.1
bikunin 9.1
VDDR 9.0
ATP6V1B1 8.9
PAT1 8.9
PH3 8.8
inter-alpha 8.7
CLC-5 8.6
GOX 8.5
LRRC8A 8.5
PolB 8.5
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Disease
hyperoxaluria 15.1
Hyperoxalemia 14.5
Enteric hyperoxaluria 14.5
Secondary oxalosis 14.0
Oxalate nephropathy 13.7
primary hyperoxaluria 12.7
oxalosis 12.3
Peroxisomal disorders 11.9
hypercalciuria 11.3
VDD1 11.3
Henoch-Schoenlein nephritis 11.3
nephrocalcinosis 11.1
glycinuria 11.1
Proximal renal tubular acidosis 10.9
nephrolithiasis 10.9
cystinuria 10.9
urolithiasis 10.8
Rhizomelic chondrodysplasia punctata 10.5
Idiopathic hypercalciuria 10.1
sponge kidney 9.9
HP2 9.9
steatorrhea 9.9
Distal renal tubular acidosis 9.9
vitamin B6 deficiency 9.8
uricosuria 9.8
hypophosphaturia 9.7
Acute renal insufficiency 9.7
cystathioninuria 9.3
ureterolithiasis 9.1
blind loop syndrome 9.1
Refsum disease 8.9
Zellweger syndrome 8.9
renal tubular acidosis 8.9
Dent's disease 8.8
phosphaturia 8.7
HP1 8.7
Fitz-Hugh-Curtis syndrome 8.6
tooth resorption 8.4
chronic urinary tract infection 8.4
sprue 8.3
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Symptom
vaginal itching 10.0
phosphatemia 9.9
renal colic 8.2
vestibulitis 8.1
frequent urination 7.7
dysuria 6.4
flank pain 5.6
intestinal bleeding 5.4
enuresis 5.4
oliguria 5.2
polyuria 5.1
urinary frequency 5.0
dental pain 4.9
colic 4.5
epigastric pain 4.3
hip pain 4.3
polydipsia 4.0
Wind 3.7
diarrhea 3.7
acute abdomen 3.5
abdominal pain 3.5
agitation 3.1
overweight 3.0
acidity 2.8
hypotonia 2.6
myalgia 2.4
arthralgia 2.3
nausea and vomiting 1.9
constipation 1.8
sleepiness 1.4
exhaustion 1.4
anorexia 1.3
vomiting 1.1
weakness 0.9
angina 0.7
pain 0.7
dyspnea 0.3
analgesia 0.3
collapse 0.3
Drug
Glafenine 11.5
Potassium citrate 11.0
Calcium citrate 10.5
Stiripentol 9.3
Profenid 9.1
Pyridoxamine 8.9
Vitamin B 8.3
Ammonium chloride 7.2
Orlistat 6.5
pyridoxal phosphate 6.4
Clofibrate 6.0
Tocopherol 5.7
Carotenoid 5.6
DMSA 5.5
Nephron 5.4
Rosiglitazone 5.4
Xanthium 5.4
Bifidobacterium 5.2
Nephron 4.9
vitamin E 4.8
ascorbate 4.5
Vitamin E 4.4
citric acid 4.4
Tacrolimus 4.4
PTH 4.4
Diurnal 4.3
G418 4.0
Alanine 3.6
Dial 3.4
Fluorescein 3.2
ROS 3.2
Angiotensin II 2.8
Glutathione 2.7
Indomethacin 2.5
NADH 1.7
Asn 1.6
ampicillin 1.1
Monit -0.0
lysine -0.8
Dermatol -2.9
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Enzyme
oxalyl-CoA decarboxylase 13.0
formyl-CoA transferase 12.4
glyoxylate reductase 11.6
glyoxylate reductase 11.6
glycolate dehydrogenase 11.3
oxalate decarboxylase 10.9
hydroxypyruvate reductase 10.2
2-oxoglutarate decarboxylase 10.2
hydroxypyruvate reductase 10.1
AGT 10.0
glycolate oxidase 9.4
BBE 9.3
oxalate oxidase 9.2
ketohexokinase 8.4
kynurenine aminotransferase 7.7
HK2 7.0
MsrA 6.7
transketolase 5.8
PAT 5.4
aldolase 5.3
acyl-CoA oxidase 5.2
urease 5.1
urease 5.0
NADPH oxidase 5.0
alpha-ketoglutarate dehydrogenase 4.8
NADPH oxidase 4.8
lactate dehydrogenase 4.7
xanthine oxidase 4.4
DCF 4.2
gamma-glutamyl transpeptidase 3.9
glucose-6-phosphate dehydrogenase 3.7
alkaline phosphatase 3.7
succinate dehydrogenase 3.7
glucose-6-phosphatase 3.5
catalase 3.5
isocitrate dehydrogenase 3.5
isocitrate dehydrogenase 3.3
superoxide dismutase 3.2
beta-glucuronidase 3.2
NADPH-diaphorase 3.2
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Compound
Maltisorb 14.1
2,3,4-trihydroxybutanoic acid 12.3
Isocarboxazide 11.9
oxalate 11.2
Isocarboxazide 11.2
Succinimide 11.2
Hydroxypyruvate 10.6
POPOP 10.2
Ethoxzolamide 10.2
oxalic acid 10.0
Pyridoxine 9.9
Glycolate 9.8
PH2 9.7
Glyoxylate 9.3
Triamterene 9.3
Bergenin 9.2
Hexachlorobutadiene 9.2
oxalic acid 9.2
oxalic acid 9.2
oxalic acid 9.1
oxalic acid 9.1
oxalic acid 9.1
oxalic acid 9.1
oxalic acid 9.1
oxalic acid 9.1
oxalic acid 9.1
oxalic acid 9.1
oxalic acid 9.1
oxalic acid 9.1
oxalic acid 9.1
oxalic acid 9.1
oxalic acid 9.1
oxalic acid 9.1
threonate 9.1
Ricinoleic acid 9.1
Pyridoxamine 8.9
Trisodium phosphate 8.9
butoxyacetic acid 8.8
D 3 8.6
Tamsulosin 8.1
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