Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020500 (hyperoxaluria)
 912 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study involved 30 patients treated with nifedipine in daily dose of 30 mg for 7 days. Calcium, magnesium, phosphate, oxalate, and uric acid levels in the urine were measured. It was found that nifedipine significantly decreased oxaluria urinary excretion of calcium, magnesium, phosphate, and uric acid remained unchanged following nifedipine therapy. Results may suggest that nifedipine may exert an influence on renal stone formation.
Pol Tyg Lek
PMID:[Effect of nifedipine on kidney output of calcium, oxalic acid, and saturation of urinary calcium oxalate]. 184 98

Various endo- and exogenous factors play a role in the urinary stones formation tract. The aim of the study was to define the type and frequency of hyperexcretion of lithogenic substances in school children population and to determine an influence of risk factors on hyperexcretion of crystallizing substances. The study included 220 school children. Preurolithiasis state (PS) was found in 30% children. The most frequently hyperoxaluria, hyperuricosuria and hypercalciuria were diagnosed and it may be connected with abnormal nutritional habits, excessive application of multivitamins, vitamin D and calcium, disturbances in drinking water chemical composition (higher amount of calcium, smaller amount of magnesium, abnormal pH). Urinary tract infections, particularly in children with obstructive uropathy are an important risk factor in the examined population. Positive familial history of urolithiasis in 43.3% children may indicate for the important role of the genetic factor in the pathogenesis of the disease.
Pol Merkur Lekarski 2000 Apr
PMID:[The role of environmental factors in the formation of kidney calculi]. 1089 97

Inhibitors of crystallization process play an important role in renal-stone forming patients. One of well-known inhibitor is citrate. The aim of the study was to define the type of metabolic abnormality in children with nephrolithiasis and the role of urinary citrate excretion. 52 children with nephrolithiasis were examined. Hypocitraturia was observed in 42.3% of patients, most frequently in children with hypercalciuria, hyperoxaluria, and hyperoxaluria with hyperuricosuria. Low urinary citrate excretion found in patients with nephrolithiasis may play an important role in the pathogenesis of the disease. Urinary citrate excretion should be examined in patients with nephrolithiasis.
Pol Merkur Lekarski 2000 Apr
PMID:[Hypocitraturia in children with urolithiasis]. 1089 2

Urolithiasis often coexists with recurrent urinary tract infections (RUTI). The aim of the study was to determine the correlation of preurolithiasis state (PS) and recurrent urinary tract infections and to establish an effect of the treatment UTI recurrence incidence. PS was found in 202(21.1%) children, most frequently: hyperoxaluria--in 61/202 (30.2%), hypercalciuria--in 32/202 (15.8%), and hyperuricosuria--in 30/202 (14.9%) children. Complex metabolic abnormality was observed in 62/202 (30.7%) patients. Therapeutic management comprised of: antibacterial prophylaxis, high fluid intake, proper diet, correction of urine pH, and pharmacological treatment if necessary. Disappearance of RUTI and PS in 88/202 (43.6%) children, disappearance of RUTI in spite of persistent PS in 36/202 (17.8%), and decrease of RUTI in 54/202 (26.7%) patients were method. In 110/202 (54.5) children PS disappeared.
Pol Merkur Lekarski 2000 Apr
PMID:[Results of the treatment of pre-urolithiasis state in children with recurrent urinary tract infections]. 1089 15