Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020500 (hyperoxaluria)
 912 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pathophysiologic consequences of renal function impairment and chronic renal failure among others result from the loss of excretory and regulatory functions of the kidneys. The role of the exchange of cellular hydrogen ions of tubular fluid in the reabsorption of bicarbonate and in the urinary excretion of titratable acid and ammonia (acid-base regulation) is outlined. The effects of decreased glomerular filtration rate on calcium and phosphorus homeostasis are discussed. De novo urolithiasis in these patients is uncommon. However, it is well recognized that they may form matrix stones with calcium oxalate inclusions. Of greater significance is the prophylaxis in those patients, in whom urolithiasis has been the cause of chronic renal failure. In these patients it is of importance to modify the drug dosage or to abandon the prophylaxis when it interferes with the metabolic changes of renal function impairment. Some agents require no modification, others minor or major modifications. Some are even contraindicated. Hazards of stone prophylaxis in chronic renal failure: Acidification - cave metabolic acidosis! Cave RTA! Antibiotic agents - special rules to prevent accumulation. Thiazides - contraindicated! Hypokalemia; hyperuricemia; cave HPT! Triamterene - contraindicated! Acetazolamide (cystinuria) - contraindicated. Spironolactone - contraindicated. Sodium-cellulose-phosphate - Hyperoxaluria, hypomagnesiuria , hyperphosphatemia, cave HPT. Orthophosphate - cave urinary infection, cave poor renal function, cave obstruction. Allopurinol - dose reduction advisable. Brenzbromaron - contraindicated.
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PMID:[Prevention of calculus recurrence in impaired kidney function]. 653 25

Presentation of the analytical results from the patients seen for lithiasic disease (LD) over a two-year period at the Hospital Reina Sofia, Tudela. This Hospital covers a homogeneous Health Area including 22 villages and a population of 76,000 people. The clinical cases of 785 patient diagnosed with LD between May 1988 and 1990 May are analyzed. Microhaematuria in fresh urine is detected in 64.20% patients and crystalluria in 33.37%. Significant bacteriuria is present in 5.73% of total patients with prevalence of E. coli in 42.4%. Only 2 cases of hyperparatiroidism were diagnosed during the study period but later another two cases of HPT were detected in bone injuries studied due to rheumatic disease. No normocalcemic HPT cases were diagnosed among suspected cases. The metabolic studies were of little use in our experience, maybe because of non-availability of basic analytical determinations such as citraturia. Nevertheless, higher values of urinary volume, calciuria and uricemia and lower values of magnesemia and magnesiuria were found in lithiasic patients that in control ones. Neither oxaluria or the remaining analytical parameters provide differential data. Hypercalciuria higher than 300 mg in seen in 28.6% of studied patients and in 12.5% of the control group.
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PMID:[Epidemics of urinary calculi in la Ribera de Navarra (II). Analytic studies]. 866 30