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Query: UMLS:C0020500 (hyperoxaluria)
 912 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A group of normal children with a free diet was studied. Their first morning urine (n = 176) and their 24-hour-urine (n = 64) was collected, valuing the calciuria, magnesiuria, uricosuria and oxaluria, establishing their relationship with a dietetic survey. Ca/Cr rate value was 0.13 +/- 0.7 mg/mg in the morning urine, and 0.12 +/- 0.06 mg/mg in the 24-hour-urine. Calciuria (mg/kg/day) was 2.46 +/- 1.45, higher to that noticed by other authors. Prevalence of hypercalciuria was 7.8%. We haven't noticed any correlation between the calciuria (mg/kg/day) and the consumption of proteins and carbohydrates. A positive correlation was found between Ca/Cr and Na/Cr rate, together with high natriuria (3.87 +/- 1.35 mEq/kg/day); these findings could justify the elevated calciuria in the children studied. Mean values of magnesium and uric acid were 0.04 +/- 0.02 and 0.30 +/- 0.08 mg/100 ml FG, respectively and the oxaluria was 34.51 +/- 16.35 mg/day/1.73 m2.
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PMID:[Urinary excretion of calcium, magnesium, uric acid and oxalic acid in normal children]. 319 27

The serum and urinary biochemical changes observed one month and six months after oral potassium citrate therapy (600 mEq/day) in 119 patients with calcium oxalate calculi were compared with those of 16 untreated cases with lithiasis. The patients that received treatment were previously divided into two groups: group A comprised 61 hypocitraturic patients and group B comprised 58 patients with other urinary disorders who were normo or hypocitraturic. The urinary pH increased by approximately half a point in both treated groups. In group A calciuria increased slightly from 180 +/- 8 to 216 +/- 10 mg/24 h but remained within the normal ranges. Creatinuria, oxaluria, uricosuria and diuresis showed no changes. Citraturia increased very significantly in both groups and more markedly in the hypocitraturic group of patients (from 198 +/- 13 to 476 +/- 35 mg/24 h). The LRC (lithogenic risk coefficient = Ca/Cit x Diu) dropped by 50%. The patients tolerated the treatment regimen well; of the 119 treated patients, only 11 abandoned treatment due to GI intolerance.
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PMID:[Biochemical effects of potassium citrate in the treatment of calcium oxalate lithiasis]. 800 70

Renal stone formation is a multifactorial process in which all the information obtained from the patient (medical history, imaging tests, stone analysis, metabolic study and physicochemical urine analysis) shows a different facet of the same process. Consequently, all these investigations should be evaluated together. In half of all patients, stone formation is secondary to the presence of metabolic alterations in urine, of which the most frequent is idiopathic hypercalciuria. The second most frequent cause is infection and/or urinary malformations, while hereditary enzyme defects are highly unusual. Reference values for urinary excretion of lithogenic metabolites (calciuria, uricosuria, oxaluria, citraturia, etc.) are essential for an adequate metabolic study, since urinary excretion depends on multiple factors, which have been described in the various publications in the literature. Physicochemical study evaluating saturation of the various salts dissolved in urine should be performed. These saturations are currently considered to be a highly useful index for determining the risk of crystallization and stone formation in patients with lithiasis and for evaluating the effectiveness of treatment. Lastly, the metabolic profile of renal lithiasis in children resembles that in adults, suggesting that predisposition to renal lithiasis begins in childhood. The early detection of the metabolic alterations observed in these patients will reduce the incidence of this disease in both children and adults.
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PMID:[Evaluation of renal stone disease: metabolic study]. 1553 Mar 22