Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020500 (
hyperoxaluria
)
912
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Of the 4,776 first grafts recorded in the pediatric European Dialysis and Transplant Association (EDTA) registry, 2,113 were reported to have failed and 5.6% of graft failures were related to a recurrence of primary renal disease. Nephrotic syndrome with focal and segmental glomerulosclerosis was the main renal disease prone to recur because recurrence represented 20% of the causes of graft failure in these patients; an even higher proportion was reported in a single-center experience in Europe. Other glomerulonephropathies, such as membranoproliferative glomerulonephritis and
Berger's disease
, were also reported to be the cause of graft failure by means of recurrence in a proportion similar to focal and segmental glomerulosclerosis. The usual recurrence of primary
oxaluria
was the cause of close to 50% of graft failure in this disease. Finally, hemolytic uremic syndrome recurred rarely with the graft in the EDTA registry, which is the opposite of what was reported in the United States.
...
PMID:Recurrence of primary renal disease on kidney graft: a European pediatric experience. 149 84
Recurrent disease does not lead to the loss of large numbers of allografted kidneys, but it is a source of serious concern in recipients with type I
hyperoxaluria
and focal segmental glomerulosclerosis. In patients with a number of other causes of renal failure, it may affect the use of living related donors. Recent topics for debate include the failure of cyclosporine to modify the incidence of recurrent disease, the realization that
IgA nephropathy
may in the long term lead to graft destruction, the fact that membranous nephropathy may recur in a quarter of the cases, and the knowledge that a nephrotic syndrome may reappear after transplantation for the Finnish congenital nephrotic syndrome.
...
PMID:Recurrent renal disease after renal transplantation. 788 83
