Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020473 (hyperlipidemia)
15,891 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulin 2556
HDL 1216
Sep 979
lipoprotein lipase 452
Mol 396
apolipoprotein 361
LDL receptor 337
apolipoprotein B 325
HMG-CoA reductase 289
apoE 268
albumin 238
reductase 233
hemoglobin 227
leptin 223
apolipoprotein E 197
fibrinogen 189
peroxisome proliferator-activated receptor 184
C-reactive protein 183
superoxide dismutase 183
tumor necrosis factor 173
gut 172
adiponectin 171
She 159
Lp(a) 140
hepatic lipase 134
TNF 133
cytokine 132
lipase 132
collagen 126
A-I 125
chronic renal failure 119
glucagon 118
catalase 118
aspartate aminotransferase 117
alanine aminotransferase 111
GSH 109
endoplasmic reticulum 109
ATP 103
glutathione peroxidase 101
renin 100
IL-6 94
fatty acid synthase 94
serum albumin 90
AMP-activated protein kinase 88
apoB-100 86
low-density lipoprotein receptor 86
peroxisome proliferator-activated receptor gamma 86
PPAR 84
HDL2 80
calcineurin 79
mTOR 79
interleukin-6 79
alkaline phosphatase 77
epididymal 76
AST 73
AMPK 72
Pol 71
proprotein convertase subtilisin/kexin type 9 71
cholesteryl ester transfer protein 70
MRI 68
plasminogen activator inhibitor-1 67
creatine kinase 66
amylase 65
ACE 64
growth hormone 64
thrombin 63
CYP7A1 62
angiotensin II 62
protease inhibitor 61
lactate dehydrogenase 61
SOD 59
cytochrome P450 57
lipopolysaccharide 56
LDLR 56
CD36 55
apolipoprotein A-I 54
acetyl-CoA carboxylase 53
vascular endothelium 53
glucose-6-phosphatase 53
LPL 51
more...
Disease
hyperlipidemia 15891
diabetes 4598
hypertension 4271
obesity 2714
atherosclerosis 2576
cardiovascular disease 1398
hyperglycemia 1196
hypercholesterolemia 1169
type 2 diabetes 1040
coronary artery disease 963
metabolic syndrome 831
stroke 764
coronary heart disease 753
dyslipidemia 677
myocardial infarction 610
fatty liver 545
cancer 532
renal disease 531
proteinuria 424
hyperinsulinemia 422
glucose intolerance 404
myocardial ischemia 345
nephrotic syndrome 341
plaque 302
heart failure 294
vascular disease 280
HIV 229
pancreatitis 219
ischemia 218
renal failure 211
depression 206
heart disease 205
hyperlipoproteinemia 195
osteoporosis 189
tumor 181
arteriosclerosis 179
cirrhosis 176
anemia 176
hyperuricemia 172
glomerulosclerosis 170
chronic renal failure 168
acute pancreatitis 166
liver disease 164
hypothyroidism 161
acute myocardial infarction 161
diabetic nephropathy 149
lipodystrophy 136
hypoglycemia 135
dementia 131
Nonalcoholic fatty liver 125
Alzheimer's disease 123
hepatocellular carcinoma 121
congestive heart failure 120
essential hypertension 111
GSH 109
systemic lupus erythematosus 106
type 1 diabetes 99
alcoholic fatty liver 97
AIDS 96
ventricular hypertrophy 96
myopathy 94
metabolic disorder 93
peripheral vascular disease 93
xanthoma 92
lipid disorder 91
atherosclerotic cardiovascular disease 90
gallstones 89
chronic obstructive pulmonary disease 87
immunodeficiency 86
renal insufficiency 85
retinopathy 84
gout 83
erectile dysfunction 83
cardiomyopathy 82
cognitive impairment 82
hyperhomocysteinemia 81
abdominal obesity 80
HDL2 80
malnutrition 77
SEM 73
more...
Symptom
overweight 281
angina 207
pain 153
hepatomegaly 88
abdominal pain 76
chest pain 76
fatigue 72
headache 69
weakness 68
diarrhea 63
vomiting 48
nausea 41
hypoproteinemia 38
anesthesia 37
hepatosplenomegaly 35
dyspnea 34
seizures 34
constipation 33
myalgia 29
vertigo 25
anorexia 25
flushing 20
dizziness 19
cough 19
cachexia 18
starvation 17
polyuria 15
dysarthria 15
discomfort 15
splenomegaly 15
shortness of breath 15
numbness 15
discomfort 14
respiratory distress 14
ataxia 14
collapse 14
insomnia 14
sleepiness 14
syncope 13
spasm 13
tremor 13
back pain 13
thinning 12
polydipsia 12
snoring 11
arthralgia 11
ketonuria 9
memory loss 9
hunger 8
erythema 8
menopausal symptoms 8
hypothermia 8
tinnitus 8
asthenia 8
nausea and vomiting 8
exertional dyspnea 8
hemiplegia 8
emaciation 7
lethargy 7
epigastric pain 7
Cushingoid 7
regurgitation 7
dysuria 6
cerebellar ataxia 6
shoulder pain 6
cyanosis 6
Ill 6
Cushingoid 6
paresis 5
leg pain 5
exertional angina 5
chyluria 5
oliguria 5
bloating 5
apathy 5
livedo 5
functional recovery 5
paresthesia 4
pallor 4
abdominal discomfort 4
more...
Drug
Cardiovasc 336
niacin 98
Simvastatin 95
vitamin E 90
Dermatol 79
Nephron 56
Nephron 51
Dial 50
Gemfibrozil 43
Monit 42
Pravastatin 37
ascorbate 37
Lovastatin 37
ROS 34
Bezafibrate 30
lysine 28
Vitamin E 27
Rosuvastatin 26
Ezetimibe 24
Ethanol 22
caffeine 22
Tacrolimus 22
Fructose 21
nitroglycerin 21
EPA 19
Clofibrate 18
Glucagon 18
Albumin 17
Adriamycin 16
Vitamin A 15
Kenyan 13
Propofol 12
Neoral 12
MAP 11
Bifidobacterium 11
PTH 10
CTX 10
Colesevelam 10
Estrogens 10
ADM 10
IL-2 9
ROC 9
EE2 9
Angiotensin II 9
Isotretinoin 8
Asn 8
ABC 8
Orlistat 8
Leaf 8
Poloxamer 8
Rosiglitazone 8
ATV 7
Ciprofibrate 7
Retinoic acid 7
Everolimus 7
Bexarotene 7
Growth hormone 6
Histamine 6
Olive oil 6
Spectrum 6
Ginseng 6
Prednisolone 6
ENT 6
Troglitazone 6
Perindopril 6
NADH 6
citric acid 6
Rutin 5
Aloe 5
ALA 5
Growth hormone 5
CSF 5
Parkin 5
Parkin 5
Lipidex 5
CTX 5
Heme 5
CTA 5
CTX 5
Colestimide 4
more...
Enzyme
lipoprotein lipase 454
superoxide dismutase 240
alanine aminotransferase 234
lipase 228
aspartate aminotransferase 188
AMP-activated protein kinase 148
catalase 139
ACE 103
glutathione peroxidase 101
creatine kinase 101
renin 100
protein kinase 99
mitogen-activated protein kinase 94
calcineurin 81
alkaline phosphatase 78
AMPK 76
AST 73
AMPK 72
3-hydroxy-3-methylglutaryl coenzyme A reductase 69
cholesterol acyltransferase 65
lactate dehydrogenase 65
thrombin 64
acetyl-CoA carboxylase 58
CYP7A1 58
tissue plasminogen activator 54
glucose-6-phosphatase 53
LPL 51
ERK 51
peroxidase 46
gamma-glutamyl transpeptidase 39
reverse transcriptase 38
protein kinase C 38
CPT 37
lecithin:cholesterol acyltransferase 33
3-hydroxy-3-methylglutaryl-CoA reductase 32
NADPH oxidase 32
caspase-3 30
CAD 30
CAD 30
CAD 30
NO synthase 28
glucose-6-phosphate dehydrogenase 28
luciferase 28
focal adhesion kinase 28
APC 27
hormone-sensitive lipase 27
NADPH oxidase 26
proprotein convertase 25
ATPase 25
acetylcholinesterase 25
subtilisin 23
thromboplastin 23
xanthine oxidase 23
cholinesterase 23
alpha-glucosidase 21
phosphoenolpyruvate carboxykinase 21
phosphodiesterase 21
phospholipase A2 19
ACS 18
paraoxonase 18
asparaginase 17
CYP3A4 17
acyl-CoA oxidase 17
furin 17
glutathione reductase 16
diacylglycerol acyltransferase 15
paraoxonase 15
phosphoenolpyruvate carboxykinase 14
glucokinase 14
phosphoenolpyruvate carboxykinase 14
proteasome 14
glutathione S-transferase 13
CPT 13
MEK 12
aldehyde dehydrogenase 12
GSK 12
CYP27A1 12
CPT 12
cholesterol esterase 12
alcohol dehydrogenase 12
more...
Compound
glucose 2113
Clin 1534
Dec 1151
Cardiol 486
water 366
creatinine 354
calcium 351
oxygen 309
DNA 264
Cholesterol 250
sodium 234
nitric oxide 213
Insulin 212
ethanol 189
acetate 153
urea 139
TNF 133
nicotinic acid 119
phosphate 113
GSH 110
GSH 110
salt 109
homocysteine 106
arginine 106
nitrogen 106
nicotinic acid 105
ATP 103
glycerol 101
nicotinic acid 99
nicotinic acid 99
CoA 95
sulfate 95
His 91
Atorvastatin 81
potassium 81
iron 73
palmitic acid 73
Triton 71
galactose 63
alloxan 61
Triton WR-1339 61
Fenofibrate 58
palmitic acid 56
methionine 55
Statin 53
ADP 53
Dial 51
MDA 51
STZ 50
vitamin D 50
Estrogen 49
copper 49
HMG-CoA 48
hydrogen 48
FFA 47
Cyclosporine 46
CO2 44
cysteine 43
Rapamycin 43
ADP 41
aldosterone 40
ADP 40
zinc 39
tyrosine 39
retinol 38
cAMP 37
prostacyclin 36
PMA 36
lysine 35
leucine 35
Lovastatin 34
Metformin 33
Metformin 33
Vitamin E 32
Pravastatin 32
ASA 32
methanol 32
TSH 31
alanine 31
AMP 31
more...