Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulin 2556
HDL 1216
Sep 979
lipoprotein lipase 452
Mol 396
apolipoprotein 361
LDL receptor 337
apolipoprotein B 325
HMG-CoA reductase 289
apoE 268
albumin 238
reductase 233
hemoglobin 227
leptin 223
apolipoprotein E 197
fibrinogen 189
peroxisome proliferator-activated receptor 184
C-reactive protein 183
superoxide dismutase 183
tumor necrosis factor 173
gut 172
adiponectin 171
She 159
Lp(a) 140
hepatic lipase 134
TNF 133
lipase 132
cytokine 132
collagen 126
A-I 125
chronic renal failure 119
glucagon 118
catalase 118
aspartate aminotransferase 117
alanine aminotransferase 111
endoplasmic reticulum 109
GSH 109
ATP 103
glutathione peroxidase 101
renin 100
fatty acid synthase 94
IL-6 94
serum albumin 90
AMP-activated protein kinase 88
low-density lipoprotein receptor 86
peroxisome proliferator-activated receptor gamma 86
apoB-100 86
PPAR 84
HDL2 80
mTOR 79
calcineurin 79
interleukin-6 79
alkaline phosphatase 77
epididymal 76
AST 73
AMPK 72
Pol 71
proprotein convertase subtilisin/kexin type 9 71
cholesteryl ester transfer protein 70
MRI 68
plasminogen activator inhibitor-1 67
creatine kinase 66
amylase 65
growth hormone 64
ACE 64
thrombin 63
angiotensin II 62
CYP7A1 62
lactate dehydrogenase 61
protease inhibitor 61
SOD 59
cytochrome P450 57
lipopolysaccharide 56
LDLR 56
CD36 55
apolipoprotein A-I 54
vascular endothelium 53
glucose-6-phosphatase 53
acetyl-CoA carboxylase 53
CHD 51
LPL 51
prothrombin 51
calcineurin inhibitor 49
SREBP-1c 48
nitric oxide synthase 48
adipokine 47
antioxidant enzyme 47
NIDDM 46
NMR 46
TNF-alpha 45
calcium channel 43
SREBP-2 43
A-II 42
GSD 42
Apolipoprotein E 42
microsomal 41
thyroid hormone 41
insulin receptor 41
pancreatic lipase 41
ADP 40
vascular cell adhesion molecule-1 40
plasminogen activator inhibitor 40
vascular endothelial growth factor 39
A-1 39
peroxisome proliferator-activated receptor alpha 39
IRS-1 39
Mal 39
FAS 38
PI3K 38
antithrombin III 38
Men 38
Leptin 38
casein 38
caspase-3 38
factor VII 38
PLA 37
microsomal triglyceride transfer protein 37
low density lipoprotein receptor 37
nuclear receptor 35
angiotensin receptor 35
Adiponectin 35
MAPK 35
STZ 34
CRP 34
ROS 34
p38 34
Bcl-2 34
CD4 33
endothelial nitric oxide synthase 33
tissue plasminogen activator 33
LCAT 32
parathyroid hormone 32
fibronectin 32
angiotensin II receptor 31
ICD 31
TLR4 31
sterol regulatory element-binding protein 31
Peroxisome proliferator-activated receptor 31
glucose transporter 31
chemokine 30
AKT 30
ABCA1 30
CAD 30
inducible nitric oxide synthase 29
LDH 29
LXR 28
endothelin-1 28
SREBP-1 28
Lipoprotein lipase 28
farnesoid X receptor 28
Gen 28
eNOS 28
ACC 28
Ang II 28
GLUT4 28
apolipoprotein A1 27
ferritin 27
glucosidase 27
APOE 27
AMP 27
more...
Disease
hyperlipidemia 15891
diabetes 4598
hypertension 4271
obesity 2714
atherosclerosis 2576
cardiovascular disease 1398
hyperglycemia 1196
hypercholesterolemia 1169
type 2 diabetes 1040
coronary artery disease 963
metabolic syndrome 831
stroke 764
coronary heart disease 753
dyslipidemia 677
myocardial infarction 610
fatty liver 545
cancer 532
renal disease 531
proteinuria 424
hyperinsulinemia 422
glucose intolerance 404
myocardial ischemia 345
nephrotic syndrome 341
plaque 302
heart failure 294
vascular disease 280
HIV 229
pancreatitis 219
ischemia 218
renal failure 211
depression 206
heart disease 205
hyperlipoproteinemia 195
osteoporosis 189
tumor 181
arteriosclerosis 179
anemia 176
cirrhosis 176
hyperuricemia 172
glomerulosclerosis 170
chronic renal failure 168
acute pancreatitis 166
liver disease 164
acute myocardial infarction 161
hypothyroidism 161
diabetic nephropathy 149
lipodystrophy 136
hypoglycemia 135
dementia 131
Nonalcoholic fatty liver 125
Alzheimer's disease 123
hepatocellular carcinoma 121
congestive heart failure 120
essential hypertension 111
GSH 109
systemic lupus erythematosus 106
type 1 diabetes 99
alcoholic fatty liver 97
ventricular hypertrophy 96
AIDS 96
myopathy 94
peripheral vascular disease 93
metabolic disorder 93
xanthoma 92
lipid disorder 91
atherosclerotic cardiovascular disease 90
gallstones 89
chronic obstructive pulmonary disease 87
immunodeficiency 86
renal insufficiency 85
retinopathy 84
gout 83
erectile dysfunction 83
cognitive impairment 82
cardiomyopathy 82
hyperhomocysteinemia 81
abdominal obesity 80
HDL2 80
malnutrition 77
SEM 73
psoriasis 72
breast cancer 70
transient ischemic attack 69
rheumatoid arthritis 68
alcohol abuse 67
migraine 66
asthma 66
HDL3 65
neuropathy 63
cerebral infarction 63
chronic disease 62
Familial combined hyperlipidemia 62
hyperphagia 62
arthritis 60
microalbuminuria 58
cardiovascular risk factor 57
alcoholism 57
LDLR 56
diabetic retinopathy 55
obstructive sleep apnea 54
hepatitis C 54
lupus 54
infectious diseases 53
cytomegalovirus 53
uremia 53
sepsis 52
sleep apnea 51
Endothelial dysfunction 51
hepatitis 51
familial hypertriglyceridemia 50
sepsis 50
glomerulonephritis 50
intermittent claudication 49
preeclampsia 49
osteoarthritis 49
pneumonia 48
glycogen storage disease 47
cholestasis 47
thrombocytopenia 47
gestational diabetes mellitus 46
schizophrenia 46
polycystic ovary syndrome 46
unstable angina 44
cold 44
syndrome X 44
morbid obesity 43
chronic liver disease 41
FAS 39
lactic acidosis 39
peripheral neuropathy 39
nephrosis 39
renal impairment 38
prostate cancer 38
hypogonadism 38
membranous nephropathy 37
lupus 37
GSD 36
GSD 36
vasculitis 36
aggression 36
xanthomatosis 35
acute renal failure 35
epilepsy 35
hyperthyroidism 35
diabetic cardiomyopathy 34
lipoatrophy 34
cataract 34
hypercalcemia 34
infertility 33
multiple myeloma 33
genetic disorder 33
carcinogenesis 33
West 32
cholesterolemia 32
diabetic ketoacidosis 32
bone disease 32
carcinoma 31
pulmonary embolism 31
Familial hypercholesterolemia 31
pruritus 31
more...
Symptom
overweight 281
angina 207
pain 153
hepatomegaly 88
abdominal pain 76
chest pain 76
fatigue 72
headache 69
weakness 68
diarrhea 63
vomiting 48
nausea 41
hypoproteinemia 38
anesthesia 37
hepatosplenomegaly 35
dyspnea 34
seizures 34
constipation 33
myalgia 29
vertigo 25
anorexia 25
flushing 20
dizziness 19
cough 19
cachexia 18
starvation 17
splenomegaly 15
dysarthria 15
discomfort 15
numbness 15
shortness of breath 15
polyuria 15
collapse 14
sleepiness 14
discomfort 14
respiratory distress 14
insomnia 14
ataxia 14
spasm 13
syncope 13
tremor 13
back pain 13
thinning 12
polydipsia 12
arthralgia 11
snoring 11
memory loss 9
ketonuria 9
exertional dyspnea 8
erythema 8
hunger 8
hemiplegia 8
menopausal symptoms 8
tinnitus 8
asthenia 8
nausea and vomiting 8
hypothermia 8
lethargy 7
regurgitation 7
Cushingoid 7
epigastric pain 7
emaciation 7
dysuria 6
Cushingoid 6
cerebellar ataxia 6
cyanosis 6
Ill 6
shoulder pain 6
chyluria 5
livedo 5
leg pain 5
exertional angina 5
bloating 5
oliguria 5
paresis 5
functional recovery 5
apathy 5
acute abdomen 4
stigma 4
dry eye 4
arm pain 4
analgesia 4
muscle cramps 4
night sweats 4
abdominal discomfort 4
pallor 4
paresthesia 4
neck pain 4
atypical chest pain 4
lightheadedness 4
blurred vision 4
chronic back pain 4
tachypnea 4
hot flashes 3
dystonia 3
tingling 3
enuresis 3
acute stress 3
rigors 3
No adverse effect 3
flank pain 3
hypotonia 3
Wind 3
Neuropathic pain 3
colic 3
decreased appetite 3
agitation 3
rales 3
leg edema 3
acute abdominal pain 3
chest tightness 3
exertional chest pain 3
hemoptysis 3
hoarseness 2
masculinization 2
hypercapnia 2
tense 2
chills 2
orthopnea 2
Poor sleep 2
clumsiness 2
hot flushes 2
exhaustion 2
chorea 2
photophobia 2
Decreased activity 2
Stiffness 2
low back pain 2
right upper quadrant pain 2
dysesthesia 2
fasciculation 2
pedal edema 2
dry skin 2
skin irritation 2
myoclonus 2
ophthalmoplegia 2
chronic constipation 2
wrist pain 2
knee pain 2
neck stiffness 2
bone pain 2
adipsia 2
heel pain 2
autodigestion 2
Homan's sign 2
sore throat 2
cardiovascular disability 2
eye pain 2
facial droop 2
hip pain 2
torticollis 1
neurological disability 1
musculoskeletal impairment 1
cancer pain 1
paraparesis 1
generalized abdominal pain 1
Catch 1
intestinal bleeding 1
bedwetting 1
Depressive symptoms 1
more...
Drug
Cardiovasc 336
niacin 98
Simvastatin 95
vitamin E 90
Dermatol 79
Nephron 56
Nephron 51
Dial 50
Gemfibrozil 43
Monit 42
Pravastatin 37
ascorbate 37
Lovastatin 37
ROS 34
Bezafibrate 30
lysine 28
Vitamin E 27
Rosuvastatin 26
Ezetimibe 24
caffeine 22
Tacrolimus 22
Ethanol 22
nitroglycerin 21
Fructose 21
EPA 19
Clofibrate 18
Glucagon 18
Albumin 17
Adriamycin 16
Vitamin A 15
Kenyan 13
Neoral 12
Propofol 12
MAP 11
Bifidobacterium 11
PTH 10
Estrogens 10
ADM 10
CTX 10
Colesevelam 10
ROC 9
EE2 9
IL-2 9
Angiotensin II 9
Rosiglitazone 8
ABC 8
Asn 8
Orlistat 8
Poloxamer 8
Leaf 8
Isotretinoin 8
Bexarotene 7
Everolimus 7
ATV 7
Retinoic acid 7
Ciprofibrate 7
Olive oil 6
Histamine 6
Spectrum 6
citric acid 6
Ginseng 6
NADH 6
Troglitazone 6
ENT 6
Growth hormone 6
Perindopril 6
Prednisolone 6
Rutin 5
ALA 5
Growth hormone 5
Aloe 5
CSF 5
Parkin 5
Parkin 5
CTA 5
CTX 5
Lipidex 5
CTX 5
Heme 5
Captopril 4
IFN-gamma 4
TAT 4
Clopidogrel 4
Norplant 4
Cremophor EL 4
TAC 4
Colestipol 4
PCB 4
Colestimide 4
Ginger 4
Red ginseng 4
Rosuvastatin calcium 4
NAH 4
Indinavir 4
Indomethacin 4
Viagra 3
Phentolamine 3
Halofenate 3
Hakka 3
Acitretin 3
Lipitor 3
Fluorescein 3
Gel 3
Viagra 3
Lescol 3
Nitric Oxide 3
Asparaginase 3
Lipitor 3
ETA 3
Rituximab 3
HCG 3
Prograf 3
Bayer 3
Phenytoin 3
Honey 3
Colestid 3
lactose 3
Gliclazide 3
Omacor 3
Portal 3
Clinofibrate 3
Glycerol 3
Check 3
Serum albumin 3
Asthma 3
Trapidil 3
Bevacizumab 3
CVA 3
Ramipril 3
AZT 3
Lescol 3
AZT 3
Vitamin B12 2
Cilostazol 2
Raltegravir 2
Liposyn 2
CrCl3 2
Pyridoxamine 2
Avasimibe 2
FAD 2
PTC 2
Prednisone 2
Coconut oil 2
Dronedarone 2
Cellcept 2
Atenolol 2
uPA 2
Clonidine 2
CS-514 2
EPL 2
Rimonabant 2
Guar gum 2
Fluorescein 2
Retinoic Acid 2
Alliance 2
Dextrose 2
DMI 2
ADR 2
-deoxyadenosine 2
Cellcept 2
more...
Enzyme
lipoprotein lipase 454
superoxide dismutase 240
alanine aminotransferase 234
lipase 228
aspartate aminotransferase 188
AMP-activated protein kinase 148
catalase 139
ACE 103
creatine kinase 101
glutathione peroxidase 101
renin 100
protein kinase 99
mitogen-activated protein kinase 94
calcineurin 81
alkaline phosphatase 78
AMPK 76
AST 73
AMPK 72
3-hydroxy-3-methylglutaryl coenzyme A reductase 69
lactate dehydrogenase 65
cholesterol acyltransferase 65
thrombin 64
acetyl-CoA carboxylase 58
CYP7A1 58
tissue plasminogen activator 54
glucose-6-phosphatase 53
LPL 51
ERK 51
peroxidase 46
gamma-glutamyl transpeptidase 39
reverse transcriptase 38
protein kinase C 38
CPT 37
lecithin:cholesterol acyltransferase 33
3-hydroxy-3-methylglutaryl-CoA reductase 32
NADPH oxidase 32
caspase-3 30
CAD 30
CAD 30
CAD 30
NO synthase 28
focal adhesion kinase 28
luciferase 28
glucose-6-phosphate dehydrogenase 28
APC 27
hormone-sensitive lipase 27
NADPH oxidase 26
proprotein convertase 25
ATPase 25
acetylcholinesterase 25
thromboplastin 23
cholinesterase 23
subtilisin 23
xanthine oxidase 23
phosphoenolpyruvate carboxykinase 21
alpha-glucosidase 21
phosphodiesterase 21
phospholipase A2 19
paraoxonase 18
ACS 18
asparaginase 17
CYP3A4 17
furin 17
acyl-CoA oxidase 17
glutathione reductase 16
diacylglycerol acyltransferase 15
paraoxonase 15
glucokinase 14
phosphoenolpyruvate carboxykinase 14
phosphoenolpyruvate carboxykinase 14
proteasome 14
CPT 13
glutathione S-transferase 13
MEK 12
cholesterol esterase 12
CPT 12
alcohol dehydrogenase 12
aldehyde dehydrogenase 12
CYP27A1 12
P-glycoprotein 12
GSK 12
ACAT 11
hexokinase 11
caspase-1 11
farnesyltransferase 11
phosphatidylinositol 3-kinase 11
ceruloplasmin 11
adenylate cyclase 10
plasmin 10
pyruvate kinase 10
11beta-hydroxysteroid dehydrogenase 10
trypsin 10
collagenase 9
E-2 9
lipoxygenase 8
phosphorylase 8
alpha-amylase 8
aldose reductase 8
elastase 8
glycerol kinase 8
HSD 8
methylenetetrahydrofolate reductase 7
methylenetetrahydrofolate reductase 7
aldehyde dehydrogenase 7
RNA polymerase 7
aldehyde dehydrogenase 7
PARP 7
HIV-1 protease 7
aldehyde dehydrogenase 7
PDK1 7
aldehyde dehydrogenase 7
invertase 7
succinate dehydrogenase 7
urokinase-type plasminogen activator 6
NOS 6
transcriptase 6
isocitrate dehydrogenase 6
isocitrate dehydrogenase 6
sucrase 6
adenosine deaminase 6
adenosine deaminase 6
cholesterol oxidase 6
NQO1 6
MAP 6
neuraminidase 5
MIP 5
phosphoinositide 3-kinase 5
heme oxygenase 5
glycerol-3-phosphate dehydrogenase 5
pyruvate dehydrogenase 5
acyl-CoA synthetase 5
complex I 5
IKK 5
xanthine dehydrogenase 5
phospholipase C 5
lysozyme 4
phosphofructokinase 4
AGT 4
demethylase 4
cathepsin D 4
uricase 4
beta-galactosidase 4
acyl-CoA synthetase 4
endonuclease 4
sialidase 4
ATP synthase 4
ADH 4
diamine oxidase 4
dimethylarginine dimethylaminohydrolase 4
dipeptidyl peptidase IV 4
lactase 4
monoamine oxidase 4
glutamate dehydrogenase 4
glucose oxidase 4
PTA 4
pyruvate dehydrogenase 4
pyruvate dehydrogenase 4
glutamate dehydrogenase 4
AOR 4
glutamate dehydrogenase 4
more...
Compound
glucose 2113
Clin 1534
Dec 1151
Cardiol 486
water 366
creatinine 354
calcium 351
oxygen 309
DNA 264
Cholesterol 250
sodium 234
nitric oxide 213
Insulin 212
ethanol 189
acetate 153
urea 139
TNF 133
nicotinic acid 119
phosphate 113
GSH 110
GSH 110
salt 109
nitrogen 106
homocysteine 106
arginine 106
nicotinic acid 105
ATP 103
glycerol 101
nicotinic acid 99
nicotinic acid 99
sulfate 95
CoA 95
His 91
Atorvastatin 81
potassium 81
palmitic acid 73
iron 73
Triton 71
galactose 63
alloxan 61
Triton WR-1339 61
Fenofibrate 58
palmitic acid 56
methionine 55
ADP 53
Statin 53
MDA 51
Dial 51
STZ 50
vitamin D 50
copper 49
Estrogen 49
HMG-CoA 48
hydrogen 48
FFA 47
Cyclosporine 46
CO2 44
Rapamycin 43
cysteine 43
ADP 41
aldosterone 40
ADP 40
tyrosine 39
zinc 39
retinol 38
cAMP 37
PMA 36
prostacyclin 36
lysine 35
leucine 35
Lovastatin 34
Metformin 33
Metformin 33
methanol 32
Vitamin E 32
Pravastatin 32
ASA 32
TSH 31
AMP 31
alanine 31
serine 30
phosphorus 30
threonine 29
L-carnitine 29
nicotinamide 29
Curcumin 28
selenium 28
nitrate 28
DHA 27
Berberine 27
Optimal 27
iodine 27
FK506 27
Diabetol 26
Probucol 25
Angiotensin II 25
ALP 25
Pac 25
Estrogen 24
CAT 23
Oil Red O 23
CAT 23
ACTH 23
CAT 23
caffeine 22
noradrenaline 22
EDTA 21
gallic acid 21
EDTA 21
NADPH 21
Mg2+ 21
TOF 21
NADPH 21
Clofibrate 21
Fructose 21
Adriamycin 20
Homocysteine 20
stearic acid 20
stearic acid 20
NAD 20
Homocysteine 20
retinoic acid 20
stearic acid 20
acetic acid 19
EPA 19
NAD 19
Diabetol 19
Oil Red O 19
coenzyme Q10 19
glutamate 18
Hemoglobin 18
DHA 18
Glucagon 18
DHA 18
ACS 18
Phe 18
ACS 18
Abbott 17
Fibrinogen 17
glutamine 17
hydroxide 17
adenylate 17
ethyl acetate 17
Resveratrol 17
Fluvastatin 17
Thyroid 17
GPT 17
chromium 16
PEG 16
THP 16
acetonitrile 16
Malondialdehyde 16
THP 16
Vitamin D 16
Pluronic 16
betaine 16
H2O2 15
silver 15
Sodium 15
ACh 15
more...