Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

513 adolescent females attending a family planning center administered by the French Movement for Family Planning in Strasburg completed anonymous questionnaires between December 1984-June 1985 to identify the sociological and clinical characteristics of the clinic users. About 80% were 16-19 years old. 314 came unaccompanied to the center, 149 came with a friend, and 25 came with their partner. It was the 1st consultation for 278 respondents. 126 had been coming for less than 1 year, 67 for 1-2 years, 31 for 2-3 years, and 11 for more than 3 years. 83% were students. 312 resided in Strasburg or its suburbs and 201 resided elsewhere. Anonymity was the principal reason why clients travelled long distances to attend the center. 372 knew of the center through friends or sisters, 44 through the media, 40 through school, 11 through parents, and 7 through a doctor. 121 reported that their parents knew they used contraception and 382 that they did not know. 318 preferred a woman doctor for a contraceptive consultation, 180 did not care, and 6 preferred a man. Over half had their 1st menstrual period between the ages of 12 and 13. 172 were virgins at the time of their 1st consultation. The age of 1st intercourse was 14-17 years old for 81% and 15 or 16 for 48%. 155 used no contraception before visiting the center, 114 used withdrawal, 73 used condoms, 20 used spermicides, 38 used oral contraceptives (OCs) prescribed elsewhere, and 9 used other methods. 66% of prescriptions were for standard dosed pills because less than 2 years had passed since menarche, the cycles were irregular, or the client had acne or feared forgetting a pill. At the 3-month follow-up the prescription was changed to a lowdose pill in 43 cases because of side effects, while a low dose pill was changed to standard dose in 20 cases because of acne or forgetting. 24 girls came for a morning after pill and 31 for a pregnancy test. 9 reported they had already had abortions. 163 did not smoke, 152 smoked less than 1/2 pack daily, 150 smoked 1/2-1 pack, and 43 smoked more than 1 pack. 434 had a normal weight for their height and 56 were obese. 33% did not return after their 1st consulatation. Frank hyperlipidemia was rare among the clients tested.
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PMID:[Contraception in young girls. A survey conducted in the MFPF Family Planning Center, Strasbourg in 1985]. 1226 91

Maternal hyperlipidemia is a characteristic feature during pregnancy, it has been reported that modification of the maternal lipid profile can induce disturbance during pregnancy. In this study, we evaluated the impact of maternal lipid profile on the placental protein expression of two major receptors in cholesterol metabolism, the low density lipoprotein receptor (LDLr) and the scavenger receptor type B1 (SR-B1). We demonstrate an increase in the level of maternal total circulating cholesterol leads to a significant decrease in the level of the LDLr protein expression, while the level of the SR-BI expression remains unchanged. A similar change, for LDLr, is observed in association with the maternal pre-pregnancy body mass index and weight gain. Our data suggest that the LDLr plays a role in regulating cholesterol delivered to the baby from the placenta.
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PMID:Influence of maternal lipid profile on placental protein expression of LDLr and SR-BI. 1753 53

The lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (OLR1) is a newly described receptor for oxidatively modified LDL. The human pregnancy is associated with hyperlipidemia and oxidative stress. It has been reported that modification in maternal lipid profile can induce disturbance during pregnancy. In this study, we have evaluated the expression protein level of OLR1 in human term placenta of women having plasma cholesterol level lower to 7 mM or higher to 8 mM and women of gestational diabetes mellitus (GDM) by western blot analysis. The present study demonstrates that the maternal lipid profile is associated with placental protein expression of OLR1. A significant increase in the protein expression of OLR1 was observed in placenta of women with elevated plasmatic total cholesterol level (>8 mM). In addition, the placental protein expression of OLR1 is increased in mothers having the highest pre-pregnancy body mass index (BMI) and low (<7 mM) plasmatic total cholesterol level at term. Interestingly, the placental protein expression of OLR1 is increased in the presence of GDM pregnancies compared with normal lipids level pregnancies, without the modification of mRNA expression. In conclusion, placental OLR1 protein expression is associated with maternal lipid profile, pre-pregnancy BMI, and pathology of GDM.
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PMID:Modulation of placental protein expression of OLR1: implication in pregnancy-related disorders or pathologies. 1859 43

Preeclampsia is a pregnancy-specific disorder associated with hyperlipidemia. Liver X receptor (LXR) alpha and LXRbeta are key regulators of lipid homeostasis. In the current study, we investigated expression of LXRalpha, LXRbeta and their target genes in human term placenta, decidua and subcutaneous adipose tissue from pregnancies complicated by preeclampsia. Furthermore, we analyzed the protein levels of LXRalpha and LXRbeta in placenta. We also analyzed lipid concentrations in term placental tissue. Gene expression of LXRalpha, LXRbeta and fatty acid transporter CD36 was significantly decreased in placental tissues, while increased expression was observed for LXRalpha in adipose tissue, from pregnancies complicated by preeclampsia. The placental protein level of LXRbeta was reduced, and there was a positive correlation between placental LXRbeta mRNA expression and placental free fatty acids in preeclampsia. Our results suggest a possible role for LXRbeta as a transcriptional regulator in preeclampsia.
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PMID:Expression of liver X receptors in pregnancies complicated by preeclampsia. 2065 9