Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nineteen guinea pigs of one month and 11 of 30 months were given high fat diet for 3 months to produce hyperlipidemia; 16 of them followed by 3 months' normal diet to resume blood lipid level; 27 for control. The results showed that: The serum cholesterol level of the experimental groups was markedly elevated (P < 0.01) with fatty degeneration of liver. Damages in OHC, IHC, cells of stria vascularis and few myelin sheaths of cochlear nerve were seen in all experimental animals, and the reduction of cochlear damages was not seen in those animals with blood lipid level resumed to normal. Auditory dysfunction was very marked as shown by ABR in the old animals with hyperlipidemia as compared with controls (P < 0.01).
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PMID:[Inner ear damage due to hyperlipidemia in the young and old guinea pigs]. 130 62

Some clinical data concerning the relationship between hyperlipidemia and sensorineural hearing loss have been reported, however, definite mechanism causing pathological changes in the cochlea and hearing loss has not yet been clarified. We studied the mechanism of hearing loss due to hyperlipidemia in rabbits by ABR hearing examination, biochemical study of the sera, observation of the inner ear morphology by Sem and Tem. We suggest that the decreased blood supply in the inner ear during hyperlipidemia because of increased platelet aggregation and blood viscosity may be responsible for the inner ear damage. At the same time, a high lipid peroxide level in the serum and the inner ear, as well as the metabolic disorder of lipids in the inner ear may also contribute to the development of hearing loss.
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PMID:[Mechanism of inner ear damage due to hyperlipidemia]. 270 96

The negative influence of hypercholesterolemia on the blood vessels condition and following degeneration lesions of the organs is well known. The aim of our study was to estimate the lipid balance disorders influence on the small blood vessels of the brain and inner ear in the patients with hypercholesterolemia and hypertriglyceridemia on the base of the audiometric, ABR and TEOAE evaluations. In our study we observed no statistical significant differences between the mean auditory thresholds in the study and control groups as well as statistical negative correlation between cholesterol serum level and amplitudes of TEOAE. In the ABR evaluation we stated the prolonged latency of the wave III and V as well as I-III and III-V interpeaklatencies in the patients with hyperlipidemia in comparison with the control group.
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PMID:[Hearing evaluation in patients suffering from hypercholesterolemia]. 1499 20