Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We investigated lipoprotein profile of 18 non-dialysis patients with CRF and 17 patients on hemodialysis, and studied effect of LPD plus EAA on lipid metabolism of 18 non-dialysis patients with CRF. The results revealed that total triglyceride, cholesterol, LDL, VLDL, and semi-quantity of ApoCII, ApoCIII were significantly increased, and HDL, ApoAI ApoAI/ApoB rate, semiquantify of ApoCI were significantly reduced in non-dialysis patients and patients on hemodialysis; VLDL and Ccr were closely negative related in non-dialysis patients. The lipid abnormalities were more severe in non-dialysis patients complicated with hypertension than without hypertension. After 6 to 10 weeks' LPD plus EAA treatment in 18 non-dialysis patients, total triglyceride, cholesterol, LDL, VLDL were significantly reduced, and HDL, ApoAI, ApoAI/ApoB were significantly increased. We conclude that it is characterized by type IV hyperlipidemia in lipid abnormalities of patients with CRF, and LPD plus EAA treatment may improve it effectively.
Zhonghua Nei Ke Za Zhi 1991 Feb
PMID:[Effect of low protein diet, plus essential amino acids on lipid metabolism in patients with chronic renal failure]. 186 71

Hyperlipidemia is one of the main features of nephrotic syndrome (NS), which has been reported to be important in the pathogenesis of mesangial cell proliferation. In an attempt to understand if LDL of the NS patients is more nephrotoxic on the development of mesangial cell proliferation, serum lipoprotein composition of normal controls, patients of NS untreated and treated with steroid drugs were measured, moreover, the influence of LDL from each group of patients on the proliferation of human mesangial cell (HMC) were observed. Lipoprotein composition was measured by enzymic methods. LDL was prepared by ultracentrifugation and used within three weeks. HMC was cultured and identified by classical methods, mesangial cell proliferation was observed by 3H-TdR incorporation according to the dose of LDL from 20-1000 micrograms/ml and time from 24 hours to 72 hours. Our results indicated that: 1. Both the NS patients untreated and treated with steroid drugs showed hypercholesterolemia and hypertriglyceride, serum low-density lipoprotein cholesterol (LDL-ch) concentration were higher in these patients than in the normal control group but there was no significant difference between NS untreated and treated groups. 2. LDL from normal controls or NS patients had biphasic effect on HMC proliferation. Low concentration stimulated HMC proliferation in concentration dependent and time-dependent manner, where as high concentration inhibited HMC proliferation. There was no significant difference on the effect of HMC proliferation between NS untreated and treated groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Zhonghua Nei Ke Za Zhi 1994 Nov
PMID:[Effect of LDL on human mesangial cell proliferation]. 760 Aug 66

The clinical and echocardiographic variables related to postinfarction angina were evaluated in 54 patients with acute myocardial infarction. All patients underwent 2D echocardiography at 2-3 weeks after infarction. Wall motion analysis was quantified with a wall motion score index (WMSI) based on 16 left ventricular wall segments. Among the 54 patients with acute myocardial infarction 23 (42.6%) had early postinfarction angina. Multiple regression analysis demonstrated no significant difference between the patients with and without postinfarction angina in age, sex, location of infarction, Killip classification, previous angina, hypertension, hyperlipidemia, diabetes mellitus, creatine kinase level and left ventricular ejection fraction. In comparison with patients without postinfarction angina, patients with postinfarction angina had higher WMSI. It indicates that postinfarction angina appears to be related more to myocardial ischemia rather than to the infarct of myocardium.
Zhonghua Nei Ke Za Zhi 1994 Aug
PMID:[Analysis of risk factors in postinfarction angina]. 788 38

We analysed fasting serum insulin levels and its correlation with common internal medical diseases in 91 cases with obesity (BMI > 24) and that in 76 nonobese cases. The mean fasting serum insulin level in obese group was higher significantly than that in nonobese group (P < 0.001). The incidences of hypertension, coronary heart disease, cerebrovascular disease, non-insulin-dependent diabetes mellitus, hypercholesterolemia, hypertriglyceridemia, combined hyperlipidemia and serum low level of HDL-C in obese group were also higher significantly than that in nonobese group (P < 0.05 and < 0.01 respectively). The main cause of many medical diseases coexisted with obesity is hyperinsulinemia. We think that the first choice of therapy to this kind of diseases should be to reduce the body weight and to decrease the insulin resistance.
Zhonghua Nei Ke Za Zhi 1993 Oct
PMID:[Hyperinsulinemia in obesity and diseases of internal medicine]. 815 34

Sixty-two elderly men with coronary heart disease (CHD), 54 of them also suffering from hyperlipidemia, were treated with a new oral androgenic preparation (Andriol) through crossover study. The results showed that after oral Andriol administration for one month, serum estradiol/testosterone (E2/T) ratio was reduced, (P < 0.05) symptom of angina pectoris was relieved (total effective rate, 77.4%), signs of myocardial ischemia in ECG and Holter monitoring were improved (total effective rate, 68.8% and 75% respectively), serum total cholesterol (TC) and triglyceride (TG) levels were reduced dramatically (both P < 0.001) and the serum level of high density lipoprotein cholesterol (HDL-ch) was increased (P < 0.05), but the blood levels of apolipoprotein-AI (APO-AI) and B (APO-B) remained unchanged. No significant side effect of Andriol was observed.
Zhonghua Nei Ke Za Zhi 1993 Mar
PMID:[Antianginal and lipid lowering effects of oral androgenic preparation (Andriol) on elderly male patients with coronary heart disease]. 815 48

To assess the prevalence of extracranial carotid artery atherosclerosis and its relation to principal cardiovascular risk factors in Chinese elderly patients, 100 cases aged from 54 to 94 were investigated with B-mode ultrasonography. Arterial intima-media thickening, plaque, mild stenosis (defined as a plaque that obstructed > 20% of the lumen diameter), and clinically significant stenosis (> 50% in cross-sectional area) were found in 79, 49, 40 and 3 patients, respectively. There was no significant correlation between carotid atherosclerosis and coronary heart disease, cerebral infarction, hypertension, hyperlipidemia or diabetes. In contrast, the prevalence of carotid atherosclerosis was increased with age (P < 0.05), so did the severity. Thus, age is a major risk factor for carotid atherosclerosis in the elderly.
Zhonghua Nei Ke Za Zhi 1996 Jan
PMID:[The prevalence and risk factors of carotid atherosclerosis in elderly patients]. 927 42

The prevalence and risk factors of hypertension and coronary heart disease (CHD) in subjects with abnormal glucose metabolism (AGM) were studied in a population of 29,960 in the Capital Iron and Steel Corporation. The results showed that the prevalences of hypertension and CHD were 37.37% and 9.32% in diabetes group and 29.88% and 6.25% in impaired glucose tolerance group respectively. Both aging and obesity were the risk factors for AGM, hypertension and CHD. Hyperglycemia and hyperlipidemia were related to the occurrence of hypertension and CHD. Our results indicate that the prevalence of CHD and hypertension is significantly increased in AGM subjects, and they have many other risk factors of cardiovascular disease.
Zhonghua Nei Ke Za Zhi 1996 May
PMID:[Prevalence and risk factors of hypertension and coronary heart disease in the subjects with abnormal glucose metabolism]. 938 13

The health status of 623 elderly people aged 60 years and over in different residential areas of Beijing was investigated. Among them 289 lived in the Xuanwu district, an urban area, 194 lived in a suburb area of Beijing, the Daxing county and 140 lived in a mountain area of the Huairou county. It was found that the prevalence rates of overweight (BMI 24-27) and obesity (BMI > or = 28), hyperlipidemia and diabetes in urban residents were much higher than that in the suburb and mountain residents (P < 0.01 and 0.05, respectively). The rate of obesity is higher in female than in male (P < 0.05). The rates of overweight and obesity decreased with increase of age (P < 0.001). In subjects with overweight and obesity the rates of hyperlipidemia, hypertension and diabetes were higher than those in the subjects without (P < 0.001). The detected rates of coronary heart disease and calcified valvular heart disease between the four groups with different body weight did not differ significantly.
Zhonghua Nei Ke Za Zhi 1997
PMID:[The investigation of risk factors of cardiovascular diseases in elderly people in Beijing]. 981 55

Recent clinical studies showed that an independent association between hyper-insulinaemia and coronary heart disease (CHD) in men with normal glucose tolerance. In non-insulin-dependent diabetes mellitus (NIDDM) it is less clear. Therefore, we evaluated insulin-sensitivity index, plasma glucose, insulin, lipoproteins and apolipoproteins in 40 male NIDDM patients with CHD, and compared them with 36 male NIDDM patients without CHD. The insulin-sensitivity index determined by the reverse of fasting plasma glucose and insulin product. The results showed that the subjects with CHD had significantly lower insulin-sensitivity index (P < 0.01) compared to those without CHD. Using step-wise logistic regression analgsis, we found insulin-sensitivity indexes (OR 0.237, 95%CI 0.0909-0.6167, P = 0.0032) were negatively associated with CHD, and were independent from other cardiovascular risk factors such as age, body mass index, hypertension, and hyperlipemia. We conclude that in NIDDM patients with CHD are more insulin resistant compared to those without CHD. Insulin resistance is associated with CHD, and independent from other cardiovascular risk factors.
Zhonghua Nei Ke Za Zhi 1997 Mar
PMID:[Relationship between insulin resistance and coronary heart disease in non-insulin-dependent diabetes mellitus patients]. 1037 10

Xuezhikang is a new blood-lipid-regulating medicine. The components of Xuezhikang include HMG-CoA reductase inhibitor (lovastatin), unsaturated fatty acids and many kinds of amino acids. A comparative study on the effects of Xuezhikang and Simvastatin (Zocor) was carried out. One hundred and eight patients with primary hyperlipidemia were randomly divided into two groups. Group 1 consisted of 53 patients, each taking 4 Xuezhikang capsules/day (1.2 g/day) for 8 weeks and group 2 included 55 cases, each taking Zocor 10 mg/day for 8 weeks. At the end of 8 weeks, the lipid levels were compared with those of the baseline in each group. In group 1 serum levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) were decreased by 23.0%, 28.0% and 28.1% (P < 0.001) respectively and in group 2 they were reduced by 23.3%, 29.5% and 29.5% (P < 0.001) respectively. Serum level of high density lipoprotein (HDL-C) was increased by 5.0% (P > 0.05) with Xuezhikang and 14.3% (P < 0.01) with Zocor, but no significant differences were found between the two groups in TC, LDL-C, TG and HDL-C. The side effects of Xuezhikang were less than those of Zocor. It is suggested that Xuezhikang made in China is a safe, effective and tolerable lipid modulator.
Zhonghua Nei Ke Za Zhi 1997 Aug
PMID:[Effect of xuezhikang on the treatment of primary hyperlipidemia]. 1043 58


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