Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fibrates are a standard in the treatment impaired lipid metabolism, in particular in combined disorders. The classical Helsinki trial provided evidence of a decreased incidence of IHD in the treated group as compared with the group on placebo. Moreover there is some recent work which proved by statistical methods regression of atherosclerosis after fibrate administration, e.g. the angiographic study BECAIT with bezafibrate. The objective of the present study was to test the effectiveness of bezafibrate (Regadrin B, 200 mg tablets, Berlin-Chemie, FRG) in patients with combined familial hyperlipidaemia. The total cholesterol concentration dropped by 12.7% the LDL-cholesterol concentration by 8.8%. There was a significant drop of triacylglycerols by 37% and a rise of HDL-cholesterol by 24.2%. The apoB concentration declined by 11.3% and apo A-1 increased by 19.6%. The fibrinogen value dropped significantly by 15.2%, the Lp(a) value did not change significantly. The body weight in the two groups did not change significantly. The achieved results resemble those of work published abroad. In the authors opinion it is a positive feature that it proved possible to engage the patients in regular aerobic physical activity. Bezafibrate, Regadrin B was well tolerated by the patients, neither clinical nor laboratory tests revealed significant undesirable effects.
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PMID:[Bezafibrate in the treatment of familial combined hyperlipidemia and its effect on certain parameters of lipid metabolism, particularly fibrinogen]. 982 67

This study was performed to investigate the antioxidant and hepatoprotective effects of fermented red ginseng (Panax ginseng C.A. Meyer; FRG) on high-fat diet-induced hyperlipidemia in rats. Sprague-Dawley rats were divided into four groups of seven: normal control, NC; high-fat diet control, HFC; high-fat diet-0.5% FRG, HF-FRGL; and high-fat diet-1% FRG, HF-FRGH. All rats were fed a high-fat diet for eight weeks, except those in the NC group, while rats in the FRG treatment groups received drinking water containing 0.5% or 1% FRG. After eight weeks of treatment, levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C) in the serum were measured. The concentration of the oxidative stress marker malondialdehyde (MDA), and activity of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in rat liver were evaluated. Histological analysis of the liver was performed using hematoxylin and eosin. The high-fat diet markedly increased serum levels of ALT, AST, TC, TG, and LDL-C and hepatic MDA levels, while administration of FRG to the hyperlipidemic rats resulted in a significant decline in the levels of these parameters. Furthermore, the decline in the levels of serum HDL-C and hepatic SOD, CAT, and GSH-Px induced by the high-fat diet was attenuated by FRG treatment. In addition, histopathological analysis of liver sections suggested that FRG treatment also provided protection against liver damage. These results suggested that FRG improved lipid profiles, inhibited lipid peroxidation, and played a protective role against liver injury in hyperlipidemic rats.
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PMID:Antioxidant and hepatoprotective effects of fermented red ginseng against high fat diet-induced hyperlipidemia in rats. 2805 15