Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We evaluated the Du Pont Theophylline Assay, a particle-enhanced turbidimetric inhibition immunoassay (PETINIA) for the measurement of theophylline in human serum. The procedure was applied to the Cobas-Bio centrifugal analyzer, and was compared to an enzyme immunoassay (EMIT) method and a high performance liquid chromatographic (HPLC) procedure. Day-to-day precision was 3.7% (1 SD coefficient of variation) at 7.1 mg/L, 3.3% at 17.7 mg/L, and 3.9% at 27.8 mg/L. The assay was linear up to 40 mg/L, and the correlation between the PETINIA, EMIT, and HPLC methods was good [PETINIA/EMIT: y = 0.94x + 0.63, r = 0.98, Syx = 1.13; PETINIA/HPLC: y = 1.00x - 0.89, r = 0.99, Syx = 0.66, where Syx is the standard deviation of the residual error of regression], when evaluated using specimens from 135 patients receiving theophylline. No interference from hemolysis, lipemia, icterus, or other methylxanthines was observed. Of the major metabolites of theophylline, only 1,3-dimethyluric acid showed any significant cross-reactivity (2.1 mg/L apparent theophylline at 20 mg/L 1,3-dimethyluric acid). The method is reliable and cost-effective for the measurement of theophylline in serum.
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PMID:Evaluation of the Du Pont Theophylline Assay adapted to a centrifugal analyzer. 388 72

Galactomannan currently seems to be a very promising auxiliary. The aim of the present work was to examine the applicability of this auxiliary in tablet-making. Galactomannan is a polysaccharide composed of galactose and mannose, which is distributed by the Swiss firm Meyhall under the name Meyprogat. The products are numbered according to their molecular weight and polymeric degree. Thus, Meyprogat 7, 30, 60, 90, 120 and 150 can be discriminated. It is used in many areas, for example in the food industry as a stabilizing agent, and in medical therapy to cure diabetes and hyperlipidaemia. In pharmaceutical technology, it is used in low concentration (5-10%) as a disintegrant agent and in high concentration (25%) as binding agent. It is able to form a hydrophilic matrix, which results in sustained release. Theophylline was chosen as model agent. After the preformulation examinations, granulations were made by a wet method, and after this tablets were formed. Examinations were made of the granulations, the physical parameters of the tablets were determined, and the release of the effective agent from the tablets was studied. The following conclusions were drawn: 1. Galactomannan yields tablets with very good hardness. 2. Galactomannan is suitable for the formation of hydrophilic matrix tablets. Through use of this macromolecular agent, the rate of dissolution can be influenced in accordance with the desired purpose.
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PMID:[Use of galactomannan to produce hydrophilic matrix tablets]. 802 83