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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

10 cases of myocardial infarction in females (mean age, 41 years, 4 months) on estrogen/progestin compounds for oral contraception have shown up the determinant role of the associated atherogenic risk factors. All patients had 1 other risk factor. In 6 cases there was hyperlipidemia with a cholesterol of above 2.60 and hypertriglyceridemia in 1 case. A family history of coronary artery disease was present in 5 cases. There was heavy tobacco consumption in 8 of the 10 cases. All of these factors, especially in combination, increase the risk of infarction in a female on estrogen/progestin tablets and constitute a contraindication to their use. 2 of the patients had hypertension, 2 were obese, and 1 was a mild diabetic. There was no warning in 1 case in 2, and early dilatation in 4 of the 10 cases. Coronary arteriography on 5 of 7 patients so examined revealed coronary lesions involving 1 trunk. The histological appearances of the occluded segment of the left coronary trunk in the 27-year-old patient who died were those of an organized occluding thrombus, perhaps having developed over a slight thickening of the intima.
Arch Mal Coeur Vaiss 1977 Sep
PMID:[Myocardial infarct and oral contraception]. 41 87

Fibrinopeptide A (FPA) levels were measured in a group of 130 controls and patients with various types of primary hyperlipidemia to investigate whether an increased steady state level of thrombin activity is present in hyperlipidemic patients. In a subset of 56 subjects, levels of clotting factors II, VII, and X were measured as well. FPA levels in hyperlipidemic patients were not significantly different from those of control subjects. Furthermore, on multiple regression analysis, no significant relationships were found between FPA levels and the concentrations of serum cholesterol or triglyceride, or log triglyceride levels. Statistically significant relationships were found between all three clotting factor levels and triglyceride concentration. The correlation coefficients for these relationships, however, were low, so that the correlations are of questionable pathophysiological significance. A weak relationship also was found between the plasma levels of cholesterol and of factor II. Thus, although small increases in various clotting factors may be found in patients with hyperlipidemia, plasma FPA levels are normal. These data indicate that hyperlipidemia is not associated with a steady state of increased thrombin activity in vivo in humans.
Circ Res 1979 Sep
PMID:Normal levels of fibrinopeptide A in patients with primary hyperlipidemia. 45

Atherosclerotic vascular disease is very common in diabetic patients. It often occurs at an earlier age and is more severe than in nondiabetic individuals. The medical management of cardiac disease in diabetics is much the same as in nondiabetics. Risk factors such as obesity, hypertension, and hyperlipidemia must be vigorously treated, and smoking should be restricted.
Geriatrics 1979 Sep
PMID:Office management of cardiac disease in the diabetic. 46 80

Although it is widely known that patients with severe hyperlipemia may have pancreatitis, it is not generally appreciated that such patients may have recurrent abdominal pain of variable character and intensity not due to pancreatitis. Review of 35 patients followed in our clinic for 1--11 years showed that 54% had recurrent abdominal pain, while only 29% had pancreatitis. Although mild pain occurred frequently with plasma triglycerides in the 2000--5000 mg/dl range, triglycerides over 6000 mg/dl were often associated with severe pain and physical findings which necessitated hospitalization, often led to the misdiagnosis of pancreatitis and other intra-abdominal catastrophes and resulted in multiple unnecessary diagnostic studies and operations. When recognized, the pain subsided within 48 hours upon cessation of oral intake and treatment with intravenous electrolyte solutions. Furthermore, effective treatment of the hyperlipemia prevented both the attacks of severe pain and the pancreatitis which otherwise occurred (or recurred) in a significant fraction of the patients. These data confirm the existence of hyperlipemic abdominal crisis as a distinct entity and testify to the importance of recognizing this syndrome in order to avoid the occurrence of acute pancreatitis and the performance of unnecessary and potentially harmful surgery.
Ann Surg 1979 Sep
PMID:The natural history and surgical significance of hyperlipemic abdominal crisis. 48 15

Combined treatment of hyperlipidaemia with a 1000-calorie-diet and d-triiodothyronine resulted in a lowering of serum cholesterol, triglycerids and lipoproteins. Concerning cholesterol and beta-lipoproteins there was an addition of reducing effects of simultaneous dietary and drug treatment. Triglycerids are influenced by the combined treatment or by dietary treatment alone to the same extent. The levels of free fatty acids rise during combined treatment while there is no change by diet alone. These observations indicate a most successful lowering of cholesterol and beta-lipoproteins by the combined therapy, but there is an increase of free fatty acids as a metabolic side effect of d-triiodothyronine.
Fortschr Med 1979 Sep 20
PMID:[Therapy of hyperlipoproteinemia. Additive effect of the lipid-lowering agent d-triiodothyronine during dietetic treatment]. 53 45

Four adult female patients with moyamoya vessels are described. Hypertension and hyperlipidaemia were discovered in three patients. Vessels similar to moyamoya vessels were seen in the orbital and cortical collateral vessels as well as in the basal ganglia region. Attention should now be paid to the aetiological rather than the descriptive aspects of the disorder. An empirical trial of corticosteroids is worth while. Risk factors such as hypertension, hyperlipidaemia, and smoking should be eliminated.
J Neurol Neurosurg Psychiatry 1977 Sep
PMID:Multiple progressive intracranial arterial occlusions ('moyamoya' disease). 59 61

Protein-restricted diets are widely used in the dietary management of uremia. These diets are undoubtedly effective in ameliorating many aspects of the uremic syndrome. However, there is no consensus as to whether diets providing less than 0.6 g/kg per day of protein are nutritionally adequate and capable of preventing the wasting syndrome. Wasting is common in the adult patient with renal insufficiency as is growth failure in the uremic child. There is some evidence that wasted patients do less well on hemodialysis and are more prone to infection. Experimental studies in uremic animals point ot diminihsed efficiency of utilization of protein, increased gluconeogenesis from animo acids, and increased catabolism of protein in the fasting state; in addition, the metabolism of a number of individual amino acids is altered in uremia. In view of these multiple abnormalities, it would seem unwise to routinely provide less than the Recommended Daily Allowances of protein. More recent developments, i.e., supplementation of essential amino acids and perhaps alpha keto acids, may provide useful alternatives. One important aspect of dietary management, i.e. prevention of hyperlipidemia, has attracted surprisingly little attention so far. Therapy with protein restricted diets in nondialyzed uremic patients has to compete with other modalities of treatment currently available, i.e., hemodialysis and transplantation, in providing optimal medical rehabilitaiton of the patient.
Am J Clin Nutr 1978 Sep
PMID:Protein restriction in the conservative management of uremia. 68 83

One of the major problems being researched and studied by the World Health Organization is the incidence of harmful side effects in users of steroid contraceptives. A literature search indicates that Anglo-Saxon countries report alarming hyperplastic changes, particularly in the liver, blood clots, hyperlipidemia leading to high blood pressure, porphyria, atypical leiomyomas and cervical hyperplasia. Currently attention is being focused on the relationship between steroid contraceptives and breast cancer. Fazala and Paffenbarger in their study of 1770 women found such benign changes as fibroadenoma, mastopathia fibrosa cystica and papilloma intraductale. In women who had used oral contraceptives for 2-4 yrs, malignancies were 1.9% to 2.5% more frequent than in non-users; in 6 yrs of use, 11 times greater than in non-users. Estrogens, particularly mestranol has been recognized as being harmful to the liver. Length of usage is a definite factor. Beginning with 1960, relatively frequent occurrences of hepotoma in young women on the pill were noted. Caught at an early stage, peliosis hepatis can be reversed if the patient discontinues the use of contraceptives. In some cases, even after a long interval of 6 months to 10 yrs, the disease continued to develop. Liver cell adenoma in the U. S. occurs 1/500,00 to 1/1,000,000. After 5 to 7 yrs of using oral contraceptives, the chance of developing liver cell adenoma is 5 times greater; after 10 yrs of use, 35 times greater. Hepatomas rupture in 43.4% of cases when the patient had been on a contraceptive, while in only 22.2% in cases of non-users. The literature which the author investigated did not establish a clear proof that the hyperplastic changes discussed were due exclusively to usage of oral contraceptives.
Pol Tyg Lek 1978 Sep 18
PMID:[Hyperplastic changes and oral contraceptives in Anglo-Saxon countries]. 69 6

We have estimated rates of fatty acid synthesis from glucose carbon and from all 2-carbon units in liver and carcass of mice using [U-14C] glucose and 3H2O under four different nutritional states. The liver synthesized only a small fraction (2--9%) of the fatty acids that were formed from glucose carbon in mice that were fasted 24 hr, fasted--refed, or fed ad libitum. However, in fed-refed mice, the liver's role increased and now accounted for 40% of the fatty acids that were formed from glucose carbon. Under the latter conditions (fed-refed), the liver synthesized 50% of the fatty acids that were formed from all 2-carbon units. At least five-sixths of all the fatty acids synthesized de novo in the fed-refed mouse were derived from carbon fed in the glucose test meal. These studies, in contrast to most earlier studies, provide direct evidence in mice of the major contribution that dietary carbohydrate makes, especially in the liver, to the synthesis of fatty acids. In addition, we have shown that lipogenic inhibition (fasting) and activation (feeding) are most marked in liver and greater for glucose than for non-glucose-carbon. Possible implications for dietary control of carbohydrate-induced hyperlipemia and obesity are discussed.
J Lipid Res 1978 Sep
PMID:Re-evaluation of lipogenesis from dietary glucose carbon in liver and carcass of mice. 71 47

Fasting serum cholesterol and serum triglyceride levels were determined in 15 maintenance hemodialysis (MH) and 35 renal transplant (RT) patients. Fourteen of 15 MH patients (93%) had elevated triglyceride levels (greater than 140 mg/100 ml) compared to 11 of 35 RT recipients (31%) (P less than .001). Two of 15 MH patients (13%) had elevated cholesterol levels (greater than 230 mg/100 ml), compared to 18 of 35 RT recipients (51%) (P = .03). In MH patients, a positive correlation was noted between serum triglyceride levels and carbohydrate intake (P = .03). Autopsy material from 12 children who underwent MH or RT was compared to material from 16 age-matched controls; an increased collagenous content of intima, a possible early indicator of coronary artery disease, was noted more frequently (P less than .006) in index patients compared to controls. Our data demonstrate that hyperlipidemia is a frequent finding in pediatric patients treated with MH and RT, and may be associated with premature coronary artery disease.
Am J Dis Child 1976 Sep
PMID:Hyperlipidemia in pediatric hemodialysis and renal transplant patients. Associated with coronary artery disease. 78 6


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