Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The stability of Clonazepam, Diphenylhydantoin and Phenobarbital has been established in plasma and whole blood samples under a variety of storage conditions. Radioimmunoassay techniques for each of these anticonvulsants is not effected by the presence of the other anticonvulsants. Abnormal states such as icterus, hemolysis and lipemia were studied for their effects on the radioimmunoassay of these anticonvulsants. All the anticonvulsants can be stored at 37 degrees C with appropriate preservation for at least one week.
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PMID:The stability and reliability of radioimmunoassays for clonazepam, diphenylhydantoin and phenobarbital in blood, serum or plasma. 64 22

The problem of the effects of metabolic changes on drug pharmacokinetics is not yet sufficiently known. Phenytoin was used for the assessment of the effects of lipid profile disturbances on drug pharmacokinetics. Phenytoin is a lipophilic substance. It was shown that hyperlipidaemia changes phenytoin pharmacokinetics and the pattern of these changes depends on the type of hyperlipidaemia. In hypercholesterolaemia and in mixed hyperlipidaemia the blood level of free phenytoin was elevated. It should be remembered that hypercholesterolaemia and mixed hyperlipidaemia re conditions increasing the risk of phenytoin overdosage and this should be considered in establishing drug dosage.
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PMID:[The influence of hyperlipidemia on pharmacokinetics of free phenytoin]. 765 92

The study was aimed at the evaluation of changes in phenytoin pharmacokinetics during dietary induced hyperlipidemia in rabbits. It was carried out in 17 New Zealand, male rabbits, 3-month old, randomly assigned to two groups: control maintained on standard diet and experimental one fed on a high-fat diet for 2 months. Pharmacokinetic assays were performed in all animals after 2 months of the experiment. Phenytoin was given intragastrically as a single dose 10 mg/kg. Blood for assays was sampled within 48 hours after phenytoin administration. The two compartment open model for extravascular administration was used for calculations. It was demonstrated that the administration of phenytoin in the group of animals with experimental hyperlipidemia was followed by a decrease of the drug concentration in the blood serum, a drop in area under the plasma concentration-time curve, a shorter elimination half-time as well as an increase in total body clearance. All revealed changes suggest that the dietary induced hyperlipidemic state alters the pharmacokinetics of phenytoin, leading to a faster drug elimination from the body.
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PMID:The pharmacokinetics of phenytoin in rabbits with hyperlipidemia induced by high-fat diet. 776 2

The problem of the effects of metabolic changes on drug pharmacokinetics is not yet sufficiently known. Phenytoin was used for the assessment of the effects of lipid profile disturbances on drug pharmacokinetics. Phenytoin is a lipophilic substance. It was shown that hyperlipidaemia changed phenytoin pharmacokinetics and the pattern of these changes depended on the type of hyperlipidaemia. In hypercholesterolaemia and in mixed hyperlipidaemia the level of free phenytoin was raised in the blood. It should be remembered that hypercholesterolaemia and mixed hyperlipidaemia are conditions increasing the risk of phenytoin overdosage and this should be considered in establishing drug dosage.
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PMID:[The effect of hyperlipidemia on pharmacokinetics of free phenytoin]. 787 Feb 58