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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of lynestrenol and norgestrel on serum lipid levels was studied in rabbits with induced hyperlipemia. Lynestrenol and norgestre l were administered orally every day in doses of .33 and 1 mg/kg body weight, respectively. 20 days of treatment with lynestrenol significantly lowered levels of total cholesterol (p less than .02), cholesterol ester (p less than .5), phospholipids (p less than .05), and triglycerides (p less than .05). alpha- and beta-lipoproteins were not significantly changed (p more than .5). Similar effects were observed after cholesterol ether (p less than .5), phospholipids (p less than .02), alpha-lipoproteins (p less than .02), and beta-lipoproteins (p less than .05), though triglycerides were not significatnly changed (p more than .5). Both drugs increased athermatous patches on the aorta. The results demonstrate that lynestrenol and norgestrel both aggravate atherosclerosis in rabbits.
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PMID:Effect of lynoestrenol and norgestrel on serum lipids in experimental atherosclerosis in rabbits. 1230 66