Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020473 (
hyperlipidemia
)
15,891
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The group 1B phospholipase A
2
(
PLA2G1B
) is a secreted phospholipase that catalyzes the hydrolytic removal of the sn-2 fatty acyl moiety from phospholipids. This enzyme is synthesized most abundantly in the pancreas and is also expressed in the lung. The first part of this review article focuses on the role of pancreatic-derived
PLA2G1B
in mediating lipid absorption and discusses how the
PLA2G1B
-derived metabolic product contributes to cardiometabolic diseases, including obesity, hyperinsulinemia,
hyperlipidemia
, and atherosclerosis. The anti-helminth properties of
PLA2G1B
will also be discussed. The second part of this review will focus on
PLA2G1B
expressed in the lung, and in vitro data suggest that how this enzyme may modulate lung inflammation via both hydrolytic activity-dependent and -dependent mechanisms. Finally, recent studies revealing a relationship between
PLA2G1B
and cancer will also be discussed. This article is part of a Special Issue entitled Novel functions of phospholipase A2 Guest Editors: Makoto Murakami and Gerard Lambeau.
...
PMID:Group 1B phospholipase A
2
in metabolic and inflammatory disease modulation. 3000 64
