Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The injection of DL-octopamine to emerging adult honey bees (1 nanomol per individual) promptly rises the haemolymph levels of steroids, diacyl and triacylglycerols (over 100% increase occurring after 10 min). Free fatty acids are then increased (by 131%) 45 mn after injections. These responses are completely abolished by 2.5 nanomol propranolol and 0.07 nanomol cyclic somatostatin. Octopamine thus seems to be more strongly involved in the lipemia than in the glycemia regulation, by contrast with noradrenaline which is, apparently, more active on carbohydrates.
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PMID:[Interaction of propranolol and somatostatin with the octopaminergic response of honeybee lipemia in vivo]. 290 12

Saline extracts of the corpus cardiacum (CC) of Locusta migratoria activate glycogen phosphorylase in locust fat body. The response of phosphorylase to CC extracts and to synthetic adipokinetic hormone (AKH) suggests that the factor responsible for the activating effect of the CC on phosphorylase is AKH, supplemented to a minor degree with Compound II. Octopamine does not influence fat body phosphorylase activity in locusts, however, it elicits a rapid short-term hyperlipemia. In cockroaches, Periplaneta americana, injection of octopamine results in a strong activation of fat body phosphorylase within 1 min. Cockroach CC extract exerts a more prolonged effect on phosphorylase activity than does octopamine.
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PMID:Regulation of glycogen phosphorylase activity in fat body of Locusta migratoria and Periplaneta americana. 640 90