Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020473 (
hyperlipidemia
)
15,891
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Oxidative stress is an important pathological mechanism in various liver diseases.
Polygonum multiflorum
Thunb. (PM) can be used for the treatment of diseases associated with aging,
hyperlipidemia
, and oxidative stress in traditional Chinese medicine. In this study, we examined the hepatoprotective effects of the ethanolic extract of PM (
PME
) in in vitro and in vivo models. The
PME
induced expression of antioxidant-response-element- (ARE-) related genes in HepG2 cells showed a dose-dependent manner. Pretreatment of HepG2 cell with
PME
suppressed H
2
O
2
- and acetaminophen- (APAP-) induced cellular reactive oxygen species (ROS) generation and cytotoxicity. In APAP-induced mouse liver injury, pretreatment with
PME
also showed ability to increase the survival rate and reduce the severity of liver injury. Treatment with
PME
attenuated bile duct ligation-induced extrahepatic cholestatic liver injury and further increased multidrug resistance protein 4 (MRP4) and reduced organic anion-transporting polypeptide (OATP) expression. Furthermore, increased nuclear translocation of the nuclear factor erythroid 2-related factor 2 (Nrf2) was observed after treatment with
PME
in both in vivo models. In conclusion, the current study showed the hepatoprotective activity of
PME
by regulating the redox state in liver injury through Nrf2 activation and controlling hepatic bile acid homeostasis in obstructive cholestasis, through bile acid transporter expression modulation.
...
PMID:Hepatoprotective Activity of the Ethanolic Extract of
Polygonum multiflorum
Thunb. against Oxidative Stress-Induced Liver Injury. 3041 31
