Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The contribution of endogenous triglyceride fatty acids (TGFA) in alimentary lipemia was studied in ten normolipemic males under 26 years. Serum, drawn before and during absorption of 50 ml of corn oil, was separated by ultracentrifugation into two fractions, one containing chylomicrons (Sf is less than 400), the second containing all other lipoproteins (Sf is less than 400). The percent of dietary triglyceride fatty acid in each fraction of the postprandial samples was calculated using triglyceride fatty acid percent composition patterns in the meal and each fraction of the fasting and postprandial samples. Corn oil was chosen for the meal because it differs considerably from fasting serum in percent of palmitic (16:0) and linoleic (18.2) acids. The endogenous triglyceride fatty acid in the chylomicron fraction remained constant during the absorption period, while the dietary triglyceride fatty acids reached a peak level of 63 percent of the total at 4 hours and decreased to 50 percent by 8 hours. In the nonchylomicron lipoprotein fraction, the dietary triglyceride fatty acids increased throughout the test period to 29 percent of total triglyceride fatty acids at 8 hours. At 2 hours endogenous triglyceride fatty acids showed a slight increase relative to the fasting level, then decreased continuously at a slow rate so that by 8 hours it was below the fasting level. These data suggest that during alimentary triglyceridemia, dietary triglyceride fatty acies incorporated into chylomicrons during absorption are rapidly released in the serum as free fatty acids and subsequently utilized in hepatic lipoprotein production and secretion. The data also indicate that circulating endogenous triglyceride fatty acids play a role in alimentary triglyceridemia by remaining essentially constant during early and peak periods and then decreaseing to aid in the subsequent recovery.
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PMID:Endogenous fatty acids in alimentary triglyceridemia in normolipemic young males. 111 15

Our objective was to investigate the time course of postprandial lipemia and lipolytic activity in male Sprague-Dawley rats trained to eat meals containing butterfat fractions, palm oil or corn oil. Baseline and postprandial blood samples were obtained via a carotid cannula in rats fed the experimental diets for 4 wk. Rats fed saturated fats compared with corn oil showed a significantly greater peak increase in postprandial triacylglycerol concentrations. Corn oil ingestion resulted in significantly lower concentrations of cholesterol and triacylglycerol in plasma and significantly less triacylglycerol accumulation (millimoles per liter per 24 h) compared with ingestion of saturated fats. Postheparin plasma lipoprotein lipase activity and plasma insulin concentration were generally greater with ingestion of corn oil compared with palm oil or butterfat. Palm oil ingestion resulted in a biphasic plasma triacylglycerol response curve and greater postheparin plasma lipoprotein lipase activity compared with butterfat ingestion, suggesting differential effects of saturated fats on postprandial lipemia. Our results indicate that greater postprandial lipemia with ingestion of saturated fats compared with corn oil may be due in part to slower plasma triacylglycerol clearance.
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PMID:Corn oil, palm oil and butterfat fractions affect postprandial lipemia and lipoprotein lipase in meal-fed rats. 778 8