Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020473 (
hyperlipidemia
)
15,891
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Saponins of
Panax notoginseng
(Burk.) F.H. Chen have been classified as a type of composition in functional foods for numerous diseases. However, its mild effects and other characteristics limited clinical applications in diseases. Inspired by "nine steaming and nine processing" of
P. notoginseng
in traditional Chinese medicine, we developed a "steaming"-mimic protocol, which significantly changed the composition of saponins of
P. notoginseng
from the original, R1, Rg1, Re, Rb1, and Rd (raw-PNS), to the products after steaming, 20
S
/
R
-Rh1, Rk3,
Rh4
, 20
S
/
R
-Rg3, Rk1, and Rg5 (N-PNS). Surprisingly, N-PNS demonstrated promising activities in improving
hyperlipidemia
and reducing body weight and weight of white adipose tissue and the inhibition of adipogenesis in obese mice. In accordance with the results
in vivo
, N-PNS remarkably blunted adipogenesis at the early stage of differentiation dose-dependently
in vitro
. Moreover, we demonstrated that the activity may involve the adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway by promoting phosphorylation of AMPK
T172
and downregulating its downstream factors: sterol regulatory element binding protein 1c, stearoyl-CoA desaturase 1, and fatty acid synthase. Taken together, the steaming-induced eight compositions of saponins showed a very promising function in improving
hyperlipidemia
and obesity both
in vivo
and
in vitro
, providing fundamental evidence for future study and application in treatment of
hyperlipidemia
, obesity, and other lipid-related metabolic syndromes.
...
PMID:Steaming Changes the Composition of Saponins of
Panax notoginseng
(Burk.) F.H. Chen That Function in Treatment of Hyperlipidemia and Obesity. 3230 31
