Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020473 (
hyperlipidemia
)
15,891
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To quantify the cross-sectional and longitudinal effects of
hyperlipidemia
on knee osteoarthritis (KOA), we studied 13,906 middle-aged or older participants from the Dongfeng-Tongji cohort. Physical examinations were performed at baseline and follow-up.
Knee pain
was diagnosed by self-reported pain or stiffness. Clinical KOA was diagnosed from
knee pain
complains and clinical X-ray radiographs. The prevalence of
knee pain
and clinical KOA was 39.0% and 6.7% at baseline, respectively.
Hyperlipidemia
was associated with
knee pain
(OR 1.34, 1.23-1.45) and clinical KOA (1.34, 1.15-1.55). Compared with the participants without
hyperlipidemia
or use of lipid-lowering drugs, those with
hyperlipidemia
but no use of lipid-lowering drugs had higher risks of
knee pain
(1.28, 1.15-1.43) and clinical KOA (1.20, 0.97-1.48), those with
hyperlipidemia
and use of lipid-lowering drugs had the highest risks of
knee pain
(1.40, 1.26-1.56) and clinical KOA (1.45, 1.21-1.75). The risks were not elevated among participants without
hyperlipidemia
but using lipid-lowering drugs for prevention of other diseases. Furthermore, each 1-unit increase in triglyceride was associated with 9% and 5% increases in the risk of clinical KOA prevalence and clinical KOA onset, respectively. In conclusion,
hyperlipidemia
is associated with elevated risks of
knee pain
and clinical KOA among middle-aged or older adults.
...
PMID:The cross-sectional and longitudinal effect of hyperlipidemia on knee osteoarthritis: Results from the Dongfeng-Tongji cohort in China. 2885 92
It is demanded to supply foods with good quality for all the humans. With the advent of aging society, palatable and healthy foods are required to improve the quality of life and reduce the burden of finance for medical expenditure. Food hydrocolloids can contribute to this demand by versatile functions such as thickening, gelling, stabilising, and emulsifying, controlling texture and flavour release in food processing. Molar mass effects on viscosity and diffusion in liquid foods, and on mechanical and other physical properties of solid and semi-solid foods and films are overviewed. In these functions, the molar mass is one of the key factors, and therefore, the effects of molar mass on various health problems related to noncommunicable diseases or symptoms such as cancer,
hyperlipidemia
, hyperglycemia, constipation, high blood pressure,
knee pain
, osteoporosis, cystic fibrosis and dysphagia are described. Understanding these problems only from the viewpoint of molar mass is limited since other structural characteristics, conformation, branching, blockiness in copolymers such as pectin and alginate, degree of substitution as well as the position of the substituents are sometimes the determining factor rather than the molar mass. Nevertheless, comparison of different behaviours and functions in different polymers from the viewpoint of molar mass is expected to be useful to find a common characteristics, which may be helpful to understand the mechanism in other problems.
...
PMID:Molar mass effect in food and health. 3289 90
