Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Atherosclerosis is a degenerative disease responsible for the majority of deaths in the western populations. According to the idea of the reaction to injury the endothelial cells lining the vascular wall are exposed to repeated insults to their integrity. The injury results in a loss of functional attributes of endothelium and leads to a sequence of events including platelet adherence and aggregation, release of platelet granular components, migration and proliferation of medial smooth muscle cells into the intima. Examples of types of injury include chemical injury, as in hyperlipidemia, or mechanical stress associated with critical changes in vascular flow. Atherosclerosis has been considered a disease primarily concerned with lipid metabolism by regarding the intramural caseous material of atheromatous arteries as the sine qua non of the disease. The limitation of the lipid theory is that the conventional cholesterol-fed animal does not exactly reproduces the pathology of atherosclerosis. An alternative theory suggests that atherosclerosis is induced by mechanical fatigue which produces the progressive change in structure and mechanical properties of the vessel wall. In this view the lipid accumulation is a secondary phenomenon, the consequence of concomitant biochemical alterations of mural constituents. The hypothesis of reaction to injury provides a plausible explanation for the lesion formation and the different theories of atherogenesis are not mutually exclusive.
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PMID:[The vascular and metabolic mechanisms of the development of the atherosclerotic plaque]. 184 83

Abdominal aorta aneurysms are quite common in elderly people, coexisting frequently with manifestations of atherosclerotic degenerative disease and in patients with already known risk factors such as hypertension, hyperlipidemia or tobacco habits. According to the most recent pathogenic concepts, the disease is caused by the inflammation of the arterial wall, leading to the destruction of elastin, and apoptosis of the smooth muscle cells of the media, associated to biomechanical factors, rendering the aortic cylinder into a sphere, with progressive expansion, coursing with growing risks of rupture, often fatal. The enormous progress noticed in the field of cellular and molecular biology and a better understanding of the intimal mechanisms involved in the pathogenesis of the disease, together with the new achievements occurred in pharmacotherapy and genetic therapy, will be able to offer in the near future, the creation of new alternatives for the medical management of this entity, preventing and controlling its progressive and expansive nature, as well as the severe and even lethal complications that can cause. In this paper the author makes an update on the new etiopathogenic concepts and new therapeutic modalities that have been tested in the medical management of the abdominal aortic aneurysm.
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PMID:[Pathogenesis and medical treatment of the abdominal aortic aneurysm: an update]. 1705 30

A 62-year-old woman entered a cardiac rehabilitation program for help with weight loss and fitness, and also for monitoring of episodic atrial fibrillation, which had begun in 1992. She was able to exercise without triggering atrial fibrillation. Additional past medical problems included glucose intolerance (treated with diet), hyperlipidemia, hypertension, migraine headaches, degenerative disease of the spine, and a duodenal ulcer.
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PMID:ECG Quiz: Dizziness in a Cardiac Rehabilitation Patient. 2008 89