Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Patients with deficient activity of hepatic glucose-6-phosphatase (glycogen storage disease type I [GSD-I]) have fasting-induced hypoglycemia, lactic acidemia, hyperuricemia, hyperlipidemia, and a markedly increased capacity for ethanol elimination. The mechanism(s) responsible for the rapid ethanol elimination is not known but has been thought to be directly related to the enzyme defect. We postulated however, that the increased elimination of ethanol was an adaptive phenomenon that would revert toward normal with correction of other blood abnormalities by long-term maintenance of normal blood glucose concentration. Six patients were observed before treatment (group A), and four of the six were observed again 3 to 6 months after dietary treatment had normalized all blood abnormalities (group B). Patients received 16 ml/m2 absolute ethanol as a 5% solution in 0.9% sodium chloride over a 20-minute period. The rate of ethanol elimination was significantly greater (P less than 0.03) in group A than in group B (55.1 +/- 11.1 vs. 37.5 +/- 8.6 mg/dl/hr). Changes in lactate level after ethanol were also significant between the two groups (P less than 0.005). Group A showed a decrease from 9.4 +/- 0.5 to 6.4 +/- 0.4 mEq/L, whereas group B showed an increase in lactate level from 2.7 +/- 0.2 to 4.4 +/- 0.64 mEq/L. Ethanol induced no significant change in blood glucose concentration in group A, whereas there was a significant increase (P less than 0.03) in group B from 93 +/- 6 to 123 +/- 9 mg/dl.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Rapid ethanol elimination in patients with type I glycogen storage disease is an adaptive change resulting from recurrent hypoglycemia. 345 5

Experimental, epidemiological and clinical evidence indicates that salt plays a major role in the pathogenesis of arterial hypertension. Endocrine and membrane ion transport studies suggest a genetic disposition with regard to salt susceptibility. In the industrialized countries sodium intake in children probably exceeds the physiological needs. However, a reduction of salt consumption in the general paediatric population cannot be recommended as the longterm risk benefit ratio is currently unknown. In children with manifest arterial hypertension sodium intake should be reduced below 2 mval/kg/day. Diuretic therapy is an important part of antihypertensive treatment. Thiazides and in renal insufficiency furosemide are the drugs of choice. The side effects of diuretic therapy, such as hypokalemia, hyperuricemia, and hyperlipidemia, in children require further investigation.
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PMID:[Reduction of table salt and diuretic therapy in arterial hypertension in childhood]. 357 12

Osteonecrosis (ON) in young adults is a serious condition causing pain and functional disability. Thirty-eight hips with ON were treated, beginning in 1972, with a spherocylindric cup (SCC) derived from the original Luck. The mean follow-up time was six years, 11 months (minimum, one year; maximum, 12 years). The overall results, using the Merle d'Aubigne grading system, were excellent in four, very good in nine, good in nine, fair in one, and failure in seven. No acetabular protrusio was observed. The seven failures were associated with deep infection in one case and unsatisfactory technique in three. One failure was unexplained, except that the ON was Grade IV. Two failures occurred in one patient with predisposing factors, such as hyperlipidemia, hyperuricemia, and exogenous hypercortisonism. Although the results are not as satisfactory as those of total hip arthroplasty (THA) with respect to relief of persistent pain, some patients remain stable with time even after more than ten years. With correct indications and good surgical technique, SCC arthroplasty is a justifiable alternative to THA in young adults.
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PMID:Spherocylindric (Luck) cup arthroplasty for osteonecrosis of the hip. 358 61

The incidence of arterial hypertension in patients with gouty nephropathy was studied. A reverse correlation dependence was established between the clearance of uric acid and the values of systolic and diastolic pressure, directing the clinicians to controlling the hyperuricemia, in parallel with the prescription of hypotensive agents. Attention is drawn to the higher incidence of hyperlipidemia in patients with gouty nephropathy and hence--the possibility of more frequent coronary incidents. Renal insufficiency advanced earlier in the patients with gouty nephropathy and arterial hypertension.
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PMID:[Arterial hypertension in gouty nephropathy]. 376 79

A report on 12 patients with retinal vein occlusion in both eyes. In addition to advanced age (67 years on the average) the following risk factors were present, often in combination: hypertension, cardiac insufficiency, adiposity, hyperlipidemia, hyperuricemia, hypercholesterinemia, diabetes mellitus etc. The rate of retinal circulation was determined by video fluorescein angiography. A pronounced decrease in visual acuity was observed in all patients with a slower retinal circulation rate. The causes of the decrease in central visual acuity were macular edema, neovascularization with vitreal hemorrhage and rubeosis iridis with secondary glaucoma.
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PMID:[Bilateral retinal vein occlusions and general risk factors]. 397 59

The high prevalence of obesity in Europe is similar to that in other industrialized areas. Obesity and its related diseases, such as hypertension, hyperlipidemia, diabetes, and hyperuricemia, have become a major problem, particularly in terms of cost. Prospective studies in Scandinavia strongly suggest obesity and its related diseases lower life expectancy. Divergent results from the Seven Countries Study are critically discussed.
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PMID:Obesity in Europe. 406 21

In a retrospective study in 3100 patients of different ages the relationship between blood group and cardiac infarction was investigated in 450 patients. The patients were divided in two age groups: those who were 65 yr old and older and younger patients (age less than 65 yr). The predominance of blood group A in patients with cardiac infarction was highly significant in both age groups (P less than 0.005, two-tailed Chi-square test). Step-wise excluding all patients with at least one of the risk factors, hypertension, hyperuricemia, diabetes mellitus, smoking, and hyperlipemia similar results were found: the predominance of blood group A in the elderly patients with cardiac infarction was even higher than before excluding the risk factors (P less than 0.001). The predominance of blood group A was also demonstrated at a lower level in younger patients with cardiac infarction (P less than 0.05). Our investigation strongly suggests the existence of a genetic factor associated with blood group A and independent of the other risk factors which is also responsible for a greater incidence of cardiac infarction.
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PMID:ABO blood group system, age, sex, risk factors and cardiac infarction. 407 23

A 32-year-old mother of 3 who had taken .05 mg ethinyl estradiol and .5 mg norgestrel for 3 months had a severe right thoracic pain of 2 weeks' duration, which was diagnosed as pulmonary arterial thrombosis and treated with high doses of urokinase. She was first given 600 mg heparin/24 hours, then 300,000 U of urokinase over 12 hours. There was some improvement, so urokinase was repeated and heparin continued. The patient was then asymptomatic, but she was found to have hyperlipidemia, hyperglycemia, insulinemia, and uricemia. She was well 6 months later on a carbohydrate- and fat-controlled diet. High doses of urokinase are preferred by some who believe that urokinase is thrombolytic in proportion to dose, well tolerated, and not antigenic.
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PMID:[Pulmonary artery thrombosis during hormonal contraceptive therapy. Treatment with urokinase]. 483 96

Glycogen storage disease type Ib has all the clinical manifestations of glycogen storage disease type Ia such as hepatomegaly, growth retardation, bleeding tendency, hypoglycemia, hyperlactacidemia, hyperuricemia, hyperlipidemia, impaired platelet function plus neutropenia. The overall glucose-6-phosphatase activity in disrupted microsomes from liver is normal whereas glucose-6-phosphate translocase, the first enzyme in the glucose-6-phosphate transport system is absent. There is no glucose-6-phosphatase activity in vivo. Recent results show that in granulocytes the glucose-6-phosphate-dependent hexosemonophosphate-shunt is impaired.
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PMID:Glycogen storage disease type Ib. 631 72

Out of 512 recipients of kidney allotransplants 36 patients exhibiting cardiovascular complications (coronary artery disease, cerebrovascular accident, aneurysm of aorta, peripheral arterial occlusions) were compared with an age and sex matched group of recipients without cardiovascular problems. The following significant differences were observed in the study group versus the controls: high systolic and diastolic blood pressure, longer duration of hypertension before renal allografting, higher serum concentrations of cholesterol, triglycerides and uric acid, and an increased incidence of left ventricular hypertrophy and preexisting cardiovascular disease. No differences were found between the two groups as regards smoking habits, overweight, hyperparathyroidism, duration of hemodialysis treatment and type of kidney disease. Diabetes mellitus, family history of cardiovascular complications and hypertonic alterations of the eye fundus were more frequent, but not to a statistically significant extent, in the study group as compared to control patients. These findings show the need for regulation of blood pressure, hyperlipemia and hyperuricemia to ensure successful longterm rehabilitation after kidney allografting.
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PMID:[Cardiovascular diseases after kidney transplantation: an analysis of predisposing factors]. 645 62


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