Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

After nearly 10 years in clinical use, prazosin has been shown in numerous studies worldwide to be an effective antihypertensive agent over the entire range of hypertension (mild, moderate, and severe), when used alone or in multitherapy. In addition to its general effectiveness, prazosin is particularly useful in specific subpopulations of hypertensive patients, such as those with impaired renal function, those on hemodialysis, and those with concomitant heart block, bronchospasm, diabetes mellitus, or disturbed carbohydrate metabolism, hyperlipidemia, or hyperuricemia. The side effects of prazosin are usually mild and transient and seldom require discontinuation of the drug. Sexual dysfunction is uncommon. In clinical experience with 22,000 patients receiving an initial dose of 1 mg of prazosin, syncope was reported in 1 of every 667 patients (0.15%). Withholding diuretics for 1 day before initiating prazosin therapy, utilizing prazosin as first-line therapy, limiting the initial dose to 1 mg, and taking it at bedtime are all helpful in eliminating many of the initial adverse effects. Fluid retention, although rare and not as pronounced as that with other antihypertensive agents, may develop on long-term therapy and may necessitate the addition of a diuretic later on.
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PMID:Effectiveness of prazosin as initial antihypertensive therapy. 682 27

Background. The aim of this study was to assess sexual function before and after cardiac rehabilitation in relation to medical variables. Methods. Analysis of patients participating in a 12-week exercise-based outpatient cardiac rehabilitation program (OCR) between April 1999 and December 2007. Exercise capacity (ExC) and quality of life including sexual function were assessed before and after OCR. Results. Complete data were available in 896 male patients. No sexual activity at all was indicated by 23.1% at baseline and 21.8% after OCR, no problems with sexual activity by 40.8% at baseline and 38.6% after OCR. Patients showed an increase in specific problems (erectile dysfunction and lack of orgasm) from 18% to 23% (P < .0001) during OCR. We found the following independent positive and negative predictors of sexual problems after OCR: hyperlipidemia, age, CABG, baseline ExC and improvement of ExC, subjective physical and mental capacity, and sense of affiliation. Conclusions. Sexual dysfunction is present in over half of the patients undergoing OCR with no overall improvement during OCR. Age, CABG, low exercise capacity are independent predictors of sexual dysfunction after OCR.
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PMID:Sexual Dysfunction before and after Cardiac Rehabilitation. 2211 Sep 69