Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cholesteryl ester transfer from solid-phase bound HDL to endogenous plasma HDL or VLDL/LDL was determined in 50 patients with primary disorders of lipid metabolism and 27 normolipidemic subjects. Transfer to the plasma HDL pool was significantly reduced in familial hypercholesterolemia, familial combined hyperlipidemia, hypoalphalipoproteinemia and dysbetalipoproteinemia. Subfractionation of HDL revealed that the lipid transfer to HDL3 was significantly reduced in all patient groups while transfer to HDL2 was increased in those with dysbetalipoproteinemia and familial hypertriglyceridemia. Transfer to LDL and VLDL was increased only in patients with dysbetalipoproteinemia and hypoalphalipoproteinemia. Reduced transfer to HDL occurred in samples with altered HDL composition; particularly where HDL-triglyceride was significantly increased and HDL-cholesteryl esters were reduced. Transfer of cholesteryl ester to HDL3 was significantly decreased in patients with vascular disease. These findings indicate that impaired interaction of cholesteryl ester transfer protein with the HDL3 pool may contribute to the risk of coronary heart disease in patients with specific plasma lipid abnormalities.
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PMID:Relationship between cholesteryl ester transfer activity and high density lipoprotein composition in hyperlipidemic patients. 275 50

A series of 57 hyperlipidaemic patients have been investigated clinically and by measurement of cholesterol and triglyceride levels and inspection of stored serum. Two had secondary (alcoholic) hyperlipidaemia. Those with primary disorders were allocated to three groups believed to require different optimal therapy. At one year 51 of these 55 patients had lipid levels within a predetermined normal range and two others showed improvement. Despite the large number of primary hyperlipidaemic states our results suggest that in most patients successful treatment can be given according to simple classification into three therapeutic categories.
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PMID:Experience with simplified scheme of treatment of hyperlipidaemia. 485 65

To understand the sometimes complex set of disturbances that frequently affect the expression of hyperlipidemia in a patient, it is necessary to be familiar with the operation of the lipoprotein-lipid transport system. After a brief survey of this system, the author classifies the major primary and secondary disorders, discusses the salient features of the primary disorders, summarizes screening and special diagnostic tests, and offers some general principles on the treatment of primary hyperlipidemia.
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PMID:Approach to the patient with hyperlipidemia. 707 Jan 47

The cardioprotective effect of moderate alcohol consumption, which is mediated largely by an elevation of high-density lipoprotein (HDL) levels, may be absent in patients with primary disorders of lipid metabolism. In 881 untreated, unrelated patients with primary hyperlipidemia, we estimated the effect of alcohol on fasting serum HDL cholesterol concentration adjusted for age, gender, diet, and smoking with a multiple linear regression model. The number of abstainers, moderate users (1-30 g daily), and heavy alcohol consumers (> or = 30 g daily) was not different between three types of hyperlipidemia. Among hypercholesterolemic (n = 514) and combined hyperlipidemic (n = 227) patients, consumers of alcohol had higher HDL levels compared to abstainers (P(for trend) = 0.0001 and 0.0002, respectively). Heavy drinkers with combined hyperlipidemia had higher triglyceride levels compared to moderate drinkers and abstainers (P(for trend) = 0.008). Alcohol consumption had no effect on the lipid profiles in 140 patients with hypertriglyceridemia. In conclusion, combined hyperlipidemic and hypertriglyceridemic patients may profit from an encouragement to stop consuming alcohol. On the other hand, moderate use of alcohol may delay the development of coronary artery disease in hypercholesterolemic patients by an elevation of HDL levels.
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PMID:Alcohol consumption had no beneficial effect on serum lipids in a substantial proportion of patients with primary hyperlipidemia. 1102 34