Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seven hundred and fifty asymptomatic European subjects aged 16 to 69 years from an urban general practice were screened for various coronary risk factors. Required information was completed for 98.9 percent of the total sample. The incidence of individual risk factors in males and females respectively were: smoking, 52.8 percent and 45.6 percent; obesity, 26.9 percent and 30.9 percent; definite hypertension, 5.6 percent and 4.0 percent; borderline hypertension, 5.3 percent and 5.1 percent; hyperlipidaemia, 12.8 percent and 8.0 percent; impaired glucose tolerance, 1.1 percent and 1.3 percent. Respective figures for males and females with regard to numbers of risk factors present were: one or more risks present, 68.5 percent and 66.9 percent; two or more, 26.5 percent and 23.5 percent; three or more, 8.0 percent and 4.5 percent; four risk factors present, 1.6 percent and 0.3 percent.
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PMID:Distribution of various coronary risk factors in an urban general practice. 27

The kidneys play an important role in the development of cardiovascular risk factors. It is well known that heavy proteinuria can induce hyperlipidemia, the uric acid is elevated in some renal deficiencies and that hypertension develops in most end stage renal diseases. In prehypertensive states, specially in subjects with a family history of hypertension, some hemodynamic changes take place, characterized by an increase in renal vasoconstriction with a reduction in renal plasma flow and an elevation of sodium reabsorption. The mechanisms for these alterations are not well understood, but an increase in intracytosolic calcium in vascular smooth muscle cells, a reduction in vasodilatory substances such as nitric oxide and an increased sympathetic nervous activity have been proposed. In normotensive subjects with two hypertensive parents a reduction in sodium diet, an increase in protein intake or in arginine diet could prevent established essential hypertension from developing. In borderline hypertension an early therapy with low doses of calcium antagonists, ACE inhibition or diuretics could be indicated.
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PMID:Can the kidney prevent cardiovascular diseases? 874 38

The principle objective of this investigation was to establish the frequency and form of the arterial hypertension in children between 7 and 16 years in urban and rural population. Specific goals were to determine by screening method, i.e., by elimination, the arterial hypertension prevalence in relation to permanent residence (town-village), age and sex of children; to determine, by the same method, the prevalence of the essential and borderline arterial hypertension; to test the risk factors in patients with essential and borderline arterial hypertension: obesity, hereditary predisposition (relatives of the first and second line), lipids, and ten-year follow-up of children with essential arterial hypertension. The examination included 3000 children (age 7-16 years) during regular school days. Essential arterial hypertension in this study was defined as blood pressure continuously higher than 95th percentile for age and sex in at least three different measurements; secondary causes of hypertension were excluded by available clinical, laboratory and functional investigations. Borderline hypertension was defined as blood pressure continually higher than 90th percentile, and from time to time higher than 95th percentile for age and sex in at least three measurements, when the secondary causes of hypertension were excluded. The obtained results were the basis for the following conclusions: Prevalence of arterial hypertension for all children was 0.93% and was the lowest in children aged 7-8 years (0.83%), and the highest in chil dren aged 15-16 years (2.96%). Prevalence of the essential arterial hypertension was 0.37% and of borderline arterial hypertension 0.56%. Prevalence of the arterial hypertension was higher in urban than in rural population of children (1.09:0.55%), but without statistically significant difference (p>0.05). Hypertension was verified in 60.7% of family members of children with increased blood pressure. 21.4% of hypertensive children were overweight. Hyperlipidemia was noted in 4 children with essential hypertension. All children with arterial hypertension underwent 24-hours Holter monitoring. Patients with essential arterial hypertension had sinus tachycardia in 95% and patients with borderline hypertension in 60% (in stress and pressure).
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PMID:[Arterial hypertension frequency in urban and rural population of children]. 1620 4

Basic aim of this investigation was to determine the frequency and the form of the arterial hypertension in children between 7 and 16 years in urban and rural population. Particular aims were to determine by screening method, i.e., by elimination, the arterial hypertension prevalence in relation to the permanent addres (town-village), age and sex of children; to determine, by the same method, the prevalence of essential and borderline arterial hyipertension; to test the factors of risk in the patients with essential and borderline arterial hypertension: obesity, hereditary predisposition (relatives of first and second order) and lipid. The examination included 3000 children (age 7-16 years) during regular school days. Essential hypertension in this study was defined as blood pressure permanently higher than 95th percentile for age and sex on at least three distinguished measurements; secondary causes of hypertension were excluded by the available clinical, laboratory and functional investigation. Borderline hypertension was defined as blood pressure permanently higher than 90th percentile, and from time to time, higher than 95th percentile for age and sex on at least three measurements, when the secondary causes of hypertension were excluded. The results allowed the following conclusions: Prevalence of arterial hypertension for all children was 0.93% and was lowest in children aged 7-16 years (0.83%), and the highest in children aged 15-16 years (2.96%). Prevalence of essential hypertension was 0.37%, and of borderline hypertension 0.56%. Prevalence of arterial hypertension was greater in urban than in rural population of children (1,09:0.55%), but without statistically significant difference (p>0.05). Hypertension was established in 60.7% of members of families of children with increased blood pressure. 21.4% of hypertensive children were overweighted. Hyperlipidemia was noted in 4 children with essential hypertension.
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PMID:[Arterial hypertension frequency in urban and rural population of children]. 1797 53