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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors studied the peculiarities of electrocardiograms recorded under conditions of rest in 1,022 males from 40 to 59 years of age, who reflected representatively a selected unorganized population of 1,250 persons. The ECG were analysed according to the Minnesota code. Among the examined persons 9.6% were found to have "coronary" ECG changes indicating to ischemic heart disease. The tread-mill test conducted in individuals chosen for scrupulous examination made it possible to make a diagnosis of ischemic heart disease in 19.6% of 219 persons (72 of whom had hyperlipidemia). A tendency toward relative decrease in high-density lipoproteins was noted in individuals with clearly manifested signs of coronary pathology on the ECG.
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PMID:[Distribution of the electrocardiographic changes characteristic of ischemic heart disease among the male population of Leningrad in comparison with the clinical biochemical indices]. 15 74

The clinical and biochemical features of type III hyperlipoproteinemia are described in 49 patients from 23 to 70 years of age. An increase in very low-density lipoproteins (VLDL) of abnormal chemical composition was the basis for diagnosis. The untreated patients all had hypercholesterolemia and hyperglyceridemia, and, on the average, decreased concentrations of both low- and high-density lipoproteins. Seventy-four percent had xanthomas, and classic "xanthoma striata palmaris" was found in more than half. Twenty-seven percent had ischemic heart disease, detected earlier in men than in women. Twenty-seven percent had peripheral vascular disease (compared to 4% of subjects with type II hyperlipoproteinemia). Twenty-five of 35 subjects achieved normal lipid levels with dietary therapy alone. Analysis of 29 kindred showed hyperlipidemia in half of adult blood relatives; half of these had type III, the remainder usually had sample endogenous hyperglyceridemia (type IV). Only 2 of 55 children less than 20 years of age were affected, both with type IV.
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PMID:The biochemical, clinical, and genetic features of type III hyperlipoproteinemia. 16 8

Studies on lipid and lipoprotein abnormalities which are associable with ischemic heart disease were presented. None of the subjects studied for this report had clinical signs or symptoms characteristic to "familial or sporadic" hyperlipoproteinemia. Only few showed gross abnormalities in lipid chemistries which are compatible with these clinical entities. Lipid abnormalities characteristic to the majority of ischemic heart patients were modest to moderate increase of serum total and free cholesterol and triglyceride; either independent increase or combined increase of these lipid fractions. Determination of free cholesterol may favor to detect such minute abnormality in modest hyperlipidemia as seen in ischemic heart patients. As expressed by our lipoprotein PAG electrophoresis pattern, B and Bp pattern (Fig. 1) seemed to be important lipoprotein abnormalities because of high incidence of ischemic heart disease (60 to 65%). Another feature of these hyperbeta lipoproteinemic state without (B pattern) or with (Bp pattern) moderate prebeta lipoprotein is highly suggestive of premature onset of ischemic heart suggestive premature onset of ischemic heart disease in the subjects with these lipoprotein patterns. Pb battern (hyperpre-beta lipoproteinemic state) was the next, because of frequent occurrence of this pattern (approx. 30%) among the cardiovascular patients and relatively high incidence (approx. 40%) of ischemic heart disease. PB pattern (combine hyperpre-beta and hyperbeta lipoproteinemic state) occurred rarely but incidence of ischemic heart disease in the subject with this pattern was high (approx. 40%). Midband lipoprotein which is one of the unique lipoprotein species detected by PAG electrophoresis may possibly reflect disordered lipoprotein metabolism. However, its association with ischemic heart disease seemed highly unlikely. However, further studies on this and other unusual lipoproteins detectable with PAG electrophoresis seems productive. Extensive studies on cine coronary angiographically established subjects (well characterized study subjects) with this new method in addition to the others would be highly productive to obtain more reliable conclusion on this subject, and hence, to obtain more effective guide line for early identification or for prevention of coronary atherosclerosis.
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PMID:Ischemic heart disease and hyperlipidemia. 16 34

The nephrotic syndrome is the only hypoalbuminaemic state frequently associated with hyperlipidaemia. In the presence of a negative nitrogen balance, hyperlipidaemia is metabolically inappropriate and reflects the result of persistent breakaway from free fatty acid control. This lipid abnormality may result in the premature development of ischaemic heart disease in patients in whom it is not possible to control the primary renal abnormality. The authors suggest that future work should be directed towards thyroxine and insulin metabolism in nephrotic states.
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PMID:Biochemical anomalies of the nephrotic syndrome. 16 35

1. The intravenous fat-tolerance test and serum lipid and lipoprotein measurements were carried out in ninety-three normal subjects, fifty-one patients with ischaemic heart disease and thirty patients with peripheral vascular disease. 2. The fractional turnover rate of exogenous triglyceride was significantly slower in patients with ischaemic heart disease and in patients with peripheral vascular disease than in normal men. The rate was also slower in normal men than normal women. 3. Serum triglyceride and cholesterol concentrations were higher in both vascular disease groups than in control subjects. 4. The proportion of both groups of patients who had a subnormal fractional turnover rate of exogenous triglyceride was 35%, and 32% of patients had hypertriglyceridaemia in the fasting state; 27% of patients were hypercholesterolaemic. 5. Although the intravenous fat-tolerance test did not provide significantly better discrimination between cardiovascular patients and control subjects than did measurement of serum triglyceride, the results suggest that hypertriglyceridaemia in such patients may be separable into a group in which impaired triglyceride clearance may be partly responsible, and a group in which overproduction of serum triglyceride may be the major mechanism of the hyperlipidaemia.
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PMID:Intravenous fat-tolerance test in ischaemic heart disease and peripheral vascular disease. 18 30

The examination was conducted in 1048 patients with the ischaemic heart disease. Both males, and females displayed most frequently Type II hyperlipidemia. Type IV was more frequent in males, than in females. The incidence of Types IIa and IIb depended on the stage of coronary atherosclerosis, the age and sex of the patients. The concomitant diseases were found to influence the incidence of hyperlipidemia. Among the tested drugs administered in a course of therapy of 4 weeks atromidine proved to be most effective for the examined types of hyperlipidemia (IIa, IIb, IV). Hyperlipidemia relapsed in 1/3 of the patients within 1 year.
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PMID:[Drug treatment of hyperlipemia in middle-aged and old persons with ischemic heart disease]. 19 32

The results subsequent to an examination of 250 males aged 30-47 suffering from ischemic heart disease and doing strenous mental work are presented. Two variants were used in phenotyping: the first was based on not too high criteria for the cholesterol and triglycerides level (250 and 140 mg%, respectively), the second one having as a groundwork upper limits of the normal value estimated by the authors (250 and 190 mg%, respectively). It was found that, depending upon the actual value of the upper normal limit for triglycerides hyperlipidemia is demonstrable in 64 or 56% of the males. Of most frequent occurrence were the II and IV types of hyperlipoproteinemia with the latter type prevailing in both variants. Most patients with ischemic heart disease demonstrated a fall of alpha-lipoproteins, as ascertained by their separation through disc-electrophoresis in polyacrylamide gel.
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PMID:[Types of hyperlipoproteinemia in young persons with ischemic heart diseases engaged in strenuous mental work]. 19 87

The blood lipid content and lipoprotein spectrum were repeatedly tested in 216 males with ischemic heart disease for follow-up periods of 4 to 5 years. Irrespective of the type of hyperlipoproteinemia, the blood triglyceride level was marked by the greatest individual fluctuations and the level of total cholesterol by the least fluctuations. Comparison of the clinical course of ischemic heart disease with the peculiarities of the changes in the blood lipid content revealed a higher incidence of recurrent myocardial infarction and sudden death among individuals with type IIa hyperlipoproteinemia. Recurrent vascular catastrophes were observed not only in patients with stable hypercholesterolemia but also in individuals with its labile form. It is concluded that repeated tests for the blood lipid content provide for more reliable diagnosis of hyperlipidemia and the type of hyperlipoproteinemia, which is of unquestionable practical importance.
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PMID:[Lipid level in the blood, based on multiple study data, and the characteristics of the course of ischemic heart disease]. 43 11

A case is described of severe recurrent ischaemic heart disease associated with rapidly increasing and ultimately massive hyperlipidaemia. The case is discussed, with suggestions for management of similar problems.
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PMID:Fulminating hyperlipidaemia. 48 89

It was established that the content of primary (acylhydroperoxide) and secondary (intermollecular "seams" in aminophospholipids) products of lipid peroxide oxidation in blood of patients with ischemic heart disease is increased against the background of hyperlipidemia and hypercholesterolemia. It is suggested that intensification of lipid peroxide oxidation may play a role in the pathogenesis of atherosclerosis.
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PMID:[Lipid peroxides and atherosclerosis. The content of lipid peroxidation products in the blood in ischemic heart disease]. 50 74


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