Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

X-linked dominant inheritance with lethality in hemizygous males is a rare mode of inheritance. The three best-known disorders which seem to be inherited in this way, are incontinentia pigmenti (IP) Bloch-Sulzberger, oral-facial-digital I (OFD I) syndrome, and focal dermal hypoplasia (FDH syndrome, Goltz syndrome). It is the purpose of this article to give a review of the clinical and genetic aspects of the above-mentioned diseases and to add those disorders in which this mode of inheritance is discussed. These disorders are: X-linked chondrodysplasia punctata (CP), cervico-oculo-acusticus syndrome (Wildervanck syndrome, COA), congenital cataract with microcornea or slight microphthalmia, muscular dystrophy--hemizygous lethal, partial lipodystrophy with lipatrophic diabetes and hyperlipidemia, Aicardi syndrome, coxo-auricular syndrome, and Johanson-Blizzard syndrome. OTC deficiency is included in the study, although there is no lethality in utero, only in the neonatal period. A critical evaluation of the current literature is carried out.
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PMID:X-linked dominant inherited diseases with lethality in hemizygous males. 687 41

A case of cerebrotendinous xanthomatosis without hyperlipidaemia but with tendinous scanthomatosis, subtle neurological disorders and endocrine cataract is reported. Accumulation of cholestanol, a cholesterol derivative, was detected by mass fragmentography. The plasma cholestanol : cholesterol ratio was 30 times higher than normally. Treatment with chenodesoxycholic acid during 26 months brought about neurological improvement, stabilization of the cataract and xanthomatosis and return to normal of plasma cholestanol levels.
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PMID:[Cerebrotendinous xanthomatosis: long-term treatment with chenodesoxycholic acid (author's transl)]. 707 Sep 78

The relationship between cataract extraction in women and current body mass index, history of clinically relevant obesity, diabetes, hypertension, and hyperlipidemia was considered in a case-control study conducted in northern Italy. A total of 287 women who had cataract extraction and 1227 control subjects who were in the hospital for acute, nonneoplastic, nonophthalmologic, nonmetabolic, nongastroenterologic diseases were interviewed during their hospital stay. Odds ratios (ORs) and their 95% confidence intervals (CIs) were derived from multiple logistic regression equations, including terms for age, education, smoking status, current body mass index, and simultaneously the four diseases considered. Elevated current body mass index (OR, 2.2; 95% CI, 1.2 to 3.8, for > or = 30 versus < 20 kg/m2), diabetes (OR, 2.2; 95% CI, 1.4 to 3.4), hypertension (OR, 1.5; 95% CI, 1.1 to 2.0), hyperlipidemia (OR, 1.8; 95% CI, 1.2 to 2.7), and clinical history of obesity (OR, 1.5; 95% CI, 1.0 to 2.2) were associated with an increased risk of cataract extraction. The OR in two separate strata of age (< 60 and > or = 60 years) indicated that the associations of diabetes and hyperlipidemia were stronger at a younger age: the OR for diabetes was 4.6 for those younger than 60 years and 1.7 for those age 60 or over, and for hyperlipidemia the ORs were 2.8 and 1.6, respectively. Thus, the results of this study support the association in women between cataract extraction and diabetes, current overweight, history of clinically relevant obesity, hypertension, and hyperlipidemia. These findings also suggest that these factors may have some biologically independent impact on the risk of cataract.
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PMID:Selected diseases and risk of cataract in women. A case-control study from northern Italy. 760 13

From December, 1990 to June, 1992, 114 patients with diabetic retinopathy were treated ambulatorally in our department. Among them 109 cases (42 males and 67 females) were older than 45 years with 210 diseased eyes. 65 eyes suffered from simple diabetic retinopathy, 145 eyes proliferative one. The visual acuity of 105 eyes (50%) was lower than 0.3, 65 eyes (30.95%) was lower than 0.05. 100 cases (91.74%) were complicated with cardiovascular diseases, 5 cases (4.5%) with cerebrovascular accident, 56 cases (51.40%) with hyperlipemia, 42 cases (61.76%) with high viscosity of the blood. Among the ophthalmic complications, macular disease occurred in 122 eyes, cataract in 88 eyes, central retinal vein obstruction in 15 eyes, neovascular glaucoma in 5 eyes.
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PMID:[The complications of senile patients with diabetic retinopathy]. 777 92

In order to identify previously undiagnosed cases of non-insulin dependent diabetes (NIDDM) in general practice, we measured non-fasting blood-glucose in all risk patients (n = 1,790) between 35-69 years old belonging to 29 general practices in Kolding. Patients at risk for NIDDM were defined as those suffering from one or more of the following: overweight, arterial hypertension, coronary heart disease, hyperlipidaemia, stroke, gout, cataract, Dupuytren's contracture, peripheral atherosclerosis or recurrent urinary- or skin-infections. A positive result, defined as a non-fasting blood-glucose of > or = 8.0 mmol/l using the same stix-lot-nr. on Refloflux S machines, was found in 86 individuals. These were then followed up with two fasting blood-glucose measurements carried out in a central laboratory, whereby 34 patients with NIDDM were identified. The newly-diagnosed NIDDM patients mostly suffered from diseases related to the insulin resistance syndrome, and we thus recommend measurement of non-fasting blood-glucose as a screening procedure in such patients. When carrying out measurements in general practice, it is important to know the precision and accuracy of the apparatus used.
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PMID:[Selective screening for non-insulin-dependent diabetes mellitus. A study among 35-69 year-old patients at risk in general practice in Kolding]. 801 51

Corticosteroids are commonly used in combination with cyclosporine in clinical kidney recipients, and administered indefinitely to many patients. Long-term administration of steroids is associated with a number of serious side effects including hypertension, obesity, hyperlipidemia, diabetes mellitus, cataract, osteoporosis, infection, moon face, and so on. A disturbance of growth is also a serious problem in pediatric patients. It is therefore desirable to discontinue the administration of steroid in renal allograft patients. For the withdrawal of steroid, it is quite important to thoroughly inhibit the recipient immune responses during the induction phase of immunosuppression without any serious adverse effect, that the patient may not retain immunological memories against donor antigens for a long period. Thus, we have been performing extensive immunosuppressive therapy using quadruple drugs, that is, DSG, cyclosporine, mizoribine, and prednisolone, during the early stage after kidney transplantation for withdrawal of prednisolone during the maintenance stage. Up to now, 19 recipients were treated with this protocol. In these patients, 8 were completely discontinued on the steroid and have been maintaining excellent graft function 9.2 to 32 months after transplantation, and 2 were reduced on the steroid to 5 mg. The present protocol may contribute greatly toward the quality of life in renal recipients.
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PMID:Deoxyspergualin. Mode of action and clinical trials. 810 31

Diabetics form a significant proportion of patients requiring admission to medical units in Singapore. We conducted a cross-sectional study of all diabetic patients admitted to Alexandra Hospital over a two-month period (1 September 1990 to 31 October 1990). One hundred and thirty-five patients (57 males, 78 females) were entered into the study. The population characteristics, admitting medical diagnoses, complications, treatment modalities and follow-up of these patients were studied. The study group accounted for 13.1% of all hospital admissions over the study period (total admissions 1033). Eighty-seven (64.4%) were Chinese, 25 (18.5%) Indians and 23 (17.1%) Malays. Of the microvascular complications, the most common was diabetic nephropathy. Eighty-two (60.7%) patients had albuminuria and 35 (25.9%) were azotemic. Dermopathy was present in 15.5% (21) and 32.6% (44) had peripheral neuropathy. Cataracts were present in 32.6% (44) of the study population and retinopathy in 18.5% (25). Associated diseases like hypertension were detected in 51.9% (70), hyperlipidemia in 41.5% (56) and coronary heart disease in 28.1% (38) of the group. Eighty-four patients (62.2%) were treated with oral hypoglycaemic tablets, 27 (20.0%) with insulin and 24 (17.7%) were managed with diet alone. Thirty-four patients (25.2%) were admitted with acute infections, most of which were respiratory infections. The mean glycosylated haemoglobin value was 11.7%. The mean duration of hospitalisation was 6.48 days. No significant correlation was found between the glycosylated haemoglobin value and the duration of hospitalisation.
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PMID:Epidemiology of diabetes mellitus in a regional hospital medical unit. 812 45

Streptozotocin-diabetic and non-diabetic rats were given various concentrations of vanadyl sulphate in drinking water for one year. It was found that vanadyl sulphate caused significant decreases in body weight gain and plasma insulin level in non-diabetic rats, but did not significantly alter fluid and food intakes or plasma levels of glucose, triglycerides, or cholesterol. In diabetic animals, vanadyl treatment significantly alleviated or prevented the occurrence of hyperglycaemia, hypoinsulinaemia, hyperphagia, polydipsia, hyperlipidaemia, or cataract formation, but the slower body weight gain was not improved. There were gradual decreases in the intake of the compound required to correct hyperglycaemia in the values of ED50 with age of the rats. The beneficial effects of vanadyl treatment persisted 16 weeks following the withdrawal of the compound. It is concluded that vanadyl sulphate is an effective agent for chronic therapy of streptozotocin-induced diabetes in rats, and its prolonged use does not lead to the development of tolerance.
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PMID:One-year treatment of streptozotocin-induced diabetic rats with vanadyl sulphate. 819 Jun 97

There are several hypothalamic theories of aging, none of which has been validated. An approach to validation is to search for consequences of anatomic ablations of hypothalamic regions that are functional hallmarks of aging, or consequences of ablation that postpone the appearance of hallmarks of aging or extend longevity. Ablation of the hypothalamic ventromedial nucleus (VMN) in the weanling rat is associated with subsequent increased body fat, glucose intolerance, hyperlipidemia, and decreased renal function. Each of these consequences is characteristic of aging in humans and in several animal models of aging. Ablation of the hypothalamic dorsomedial nucleus (DMN) in the weanling rat leads to a symmetrically smaller animal with normal glucose and lipid metabolism, decreased body fat for size, and reduced risk of decreased renal function and circulating IGF-I levels. These are findings consistent with calorie restriction models in rodents that significantly extend life span. This review compares outcomes of lesions in the VMN, DMN, and lateral hypothalamic area (LHA) for relevance to aging. To establish a relationship between these anatomic areas of the hypothalamus and aging, it is concluded that the VMN, DMN, and LHA lesions should be examined for impact on longevity and compared with data obtained from simultaneously studied intact ad-lib-fed and 40% calorie-restricted animals. Lesioned animals also should be rigorously studied for neurotransmitters (e.g., neuropeptide Y, beta-endorphin, serotonin, corticotropin-releasing factor, and galanin), and for behavioral changes consistent with aging, for accumulation of specific tissue lipofuscin and amyloid that are associated with normal aging and for other age-dependent findings, such as incidence of tumors and cataract.
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PMID:Aging and the hypothalamus: research perspectives. 870 Sep 56

Male WBN/Kob rats represent a spontaneously diabetic strain with hyperglycemia, cataracts, nephropathy, neurophathy, pancreatic fibrosis and hyperlipemia. Cataracts and retinal changes in WBN/Kob rats were examined by light and electron microscopy to evaluate the ocular complications. Lens opacity was present in the posterior subcapsular and center of the anterior cortex of male 14-month-old WBN/Kob rats. Light and transmission electron microscopy showed swelling and irregularity of lens fibers. Scanning electron microscopy revealed that lens fibers were irregular and had many granules and bulging processes of various sizes on the cortical side of the opacified region. The nuclear side of the opacified region showed spongy changes and complete absence of lens fibers. Electron microscopy showed retinal degeneration in the photoreceptor outer segments of 1-month-old male WBN/Kob rats. Light microscopy showed thin outer segments and outer nuclear layers in 5-month-old rats, and electron microscopy revealed severe degeneration in the outer segments. The retinas of 11-month-old rats were thinner; the outer plexiform layer was very thin; the photoreceptor cell nuclei in the outer nuclear layer had decreased to one layer and were almost in contact with the inner nuclear layer nuclei, while the visual cells had disappeared. Retinal degeneration had progressed even further in 14-month-old rats, and very few photoreceptor cell nuclei remained. The retinal capillary lumens were small, and their pericytes had thickened basement membranes. The basement membranes of retinal capillaries from WBN/Kob rats were significantly thicker than those from control Wistar rats (p < 0.0001). Although this rat has spontaneous diabetic features, such as cataracts, its retinal changes look more degenerative.
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PMID:Lens and retinal changes in the WBN/Kob rat (spontaneously diabetic strain). Electron-microscopic study. 966 53


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