Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Enzyme
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Query: UMLS:C0020473 (
hyperlipidemia
)
15,891
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A patient with overt
lipemia
presented with hyponatremia,
hyperchloremia
, and a negative anion gap. The
hyperchloremia
and negative gap resulted from overestimation of chloride levels due to a light-scattering effect in the colorimetric assay, an effect that was reproducible in vitro. In a prospective study, this effect produced substantial overestimations at even modest degrees of
hyperlipemia
. This effect expands the differential diagnosis of a decreased gap, adds to the list of technique-dependent artifacts in
lipemia
, and, if present, must be recognized for a patient's fluid and electrolyte status to be accurately defined.
...
PMID:Spurious hyperchloremia and decreased anion gap in hyperlipidemia. 684 74
