Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020473 (hyperlipidemia)
 15,891 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The challenge of achieving health for all is enormous in the face of 500,000 maternal deaths a year; the fact that 2.9 billion people lack clean water and sanitation; the AIDS epidemic and malaria prevalence; substance abuse; population aging; runaway urbanization; environmental degradation; and violent human conflicts. To develop new ways of thinking and approaches, programs initiated by the Health Foundation of the Rogosin institute of New York entitled Problem-Solving for Better Health. The basic concept was that available limited resources (preventive, therapeutic, information, talent, and community) are seldom fully utilized, rather than are often wasted. The program involves attendance of a workshop lasting 3-5 days by 60 health professionals. The problem-solving strategies are discussed in large groups with a handbook for supporting presentations. Community involvement and international collaboration are stressed, and follow-up site visits take place after 6 months. The Health Foundation's INFO-MED computer program and interactive information centers provide up-to-date information for professionals working on health problems. In China, 54 professionals collaborated to solve health problems. In 1992, progress reports for 21 projects dealt with anxiety, violent behavior, attention-deficit disorders, hyperlipidemia, and wound healing. In Brazil, 53 health professionals were enrolled in 1990 and prepared some 50 solutions to problems, including patterns of violence among young males in Sao Paulo and nutritional deficiencies in slums. Six projects were implemented with 36 under development. In Ghana, 65 professionals devised solutions to problems in 1991, 12 projects are under way, and 1 on hearing problems in school children is ready for national implementation. In the US, a team from the University of Illinois Medical School launched a program in 1992 on geriatric, pediatric, and women's health issues. In Guyana, 70 professionals participated in a workshop in 1992 to strengthen community-based programs. In Nigeria, also in 1992, 78 participants prepared protocols on family planning, guinea-worm eradication, and environmental health.
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PMID:Problem-solving for better health. 814 91

Congenital rubella syndrome (CRS) consists of a group of abnormalities that develop in children as a result of maternal infection with rubella virus. CRS may lead to new physical symptoms during adolescence or adulthood, referred to as "late manifestations". Psychiatric disorders are often seen among CRS patients, with an incidence of 4.12-7.3% for autism. We report a case of adolescent CRS with autism. A 20-year-old man had received treatment with antipsychotics and antidepressants since the age of 12 years because of unstable moods, violence, and stereotypic behavior. During follow-up, he developed some insidious-onset physical problems, including hyperlipidemia, dyspnea, constipation, torticollis and a tilted trunk. Under careful survey and evaluation, some physical problems were recognized as side effects of psychotropics, which gradually subsided after adjustment of the medications, and some of the problems were considered partially as manifestations of CRS, such as progressive pulmonary artery stenosis-related dyspnea. We managed some of the patient's physical problems and then he received catheterization for pulmonary artery stenosis. His general physical condition improved and some further improvement in psychiatric status was noted thereafter. Because of a high comorbidity rate for patients with autistic disorder, the clinician should be aware of the possibility of CRS if the patient has multiple congenital physical abnormalities with a history of maternal rubella infection. If patients develop physical symptoms in adolescence, awareness of late manifestations of CRS and differentiation from the adverse effects of psychotropic medications are essential. In addition to psychiatric treatment, management of physical problems associated with CRS would be beneficial for the patients' psychiatric condition.
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PMID:Congenital rubella syndrome with autistic disorder. 2017 92